Further neurochemical and behavioural investigation of Brattleboro rats as a putative model of schizophrenia

Journal of Psychopharmacology

Volumn 24, Issue 3, 2010, Pages 407-419

  Cilia, J ^a   Gartlon, J E ^a   Shilliam, C ^a   Dawson, L A ^a   Moore, S H ^a   Jones, D N C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Amphetamine; Antipsychotics; Brattleboro rats; Dopamine; Frontal cortex; Locomotor activity; Long evans rats; Prepulse inhibition

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; AMPHETAMINE; CLOZAPINE; DOPAMINE; HALOPERIDOL; OLANZAPINE; RISPERIDONE; NEUROLEPTIC AGENT;

ACOUSTIC STRESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRATTLEBORO RAT; COGNITION; CONTROLLED STUDY; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG RESEARCH; EX VIVO STUDY; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; LIQUID CHROMATOGRAPHY; LOCOMOTION; MALE; NEUROCHEMISTRY; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STARTLE REFLEX; STEADY STATE; TANDEM MASS SPECTROMETRY; ANIMAL; BRAIN LEVEL; DOSE RESPONSE; DRUG EFFECT; FRONTAL LOBE; LONG EVANS RAT; METABOLISM; MOTOR ACTIVITY;

3,4-DIHYDROXYPHENYLACETIC ACID; AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FRONTAL LOBE; MALE; MOTOR ACTIVITY; RATS; RATS, BRATTLEBORO; RATS, LONG-EVANS; SCHIZOPHRENIA; STARTLE REACTION;

EID: 77953073585     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108098787     Document Type: Article

References (39)

1. Ashby Jr, CR, Wang, RY (1996) Pharmacological actions of the atypical antipsychotic drug clozapine: a review. Synapse 24: 349-394.
2. Bakshi, VP, Swerdlow, NR, Braff, DL, Geyer, MA (1998) Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel. and olanzapine. Biol Psychiatry 43: 436-445.
3. Birkett, SD, Pickering, BT (1988) The vasopressin precursor in the Brattleboro (di/di) rat. Int J Pept Protein Res 32: 565-572.
4. Boer, GJ, Feenstra, MGP, Botterblom, MJA, Rorse, V, Te Riele, P (1995) Early postnatal appearance of enhanced noradrenaline content in the brain of vasopressin-deficient Brattleboro rat; normal adrenoceptor densities and aberrant influences of vasopressin treatment. Int J Dev Neurosci 75: 63-74.
5. Brambilla, F, Bondiolotti, GP, Maggioni, M, Sciascia, A, Grillo, W, Sanna, F, et al. (1989) Vasopressin (DDAVP) therapy in chronic schizophrenia: effects on negative symptoms and memory. Neuropsychobiology 20: 113-119. (Pubitemid 19167976)
6. Brownfield, MS, Greathouse, J, Lorens, SA, Armstrong, J, Urban, JH, Van de Kar, LD (1988) Neuropharmacological characterization of serotoninergic stimulation of vasopressin secretion in conscious rats. Neuroendocrinology 47: 277-283. (Pubitemid 18085233)
7. Cilia, J, Hill, MDW, Reavill, C, Jones, DNC (2005) Reversal of isolation-rearing induced PPI deficits by quetiapine and ziprasidone but not by haloperidol. J Psychopharmacol. 19 (abstract Suppl. 5) MA11: A12.
8. Cilia, J, Reavill, C, Hagan, JJ, Jones, DNC (2001) Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats. Psychopharmacology 156: 327-337. (Pubitemid 32702222)
9. Dawson Jr, R, Wallace, DR, King, MJ (1990) Monoamine and amino acid content in brain regions of Brattleboro rats. Neurochem Res 15: 755-761.
10. Egashira, N, Tanoue, A, Higashihara, F, Fuchigami, H, Sano, K, Mishima, K, et al. (2005) Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs. Neuropsychopharmacology 30: 1996-2005. (Pubitemid 43093500)
11. Ellenbroek, BA, van den Kroonenberg, PTJM, Cools, AR (1998) The effects of an early stressful life event on sensorimotor gating in adult rats. Schizophr Res 30: 251-260.
12. Feenstra, MG, Snijdewint, FGM, Van Galen, H, Boer, GJ (1990) Widespread alterations in central noradrenaline, dopamine and serotonin, systems in the Brattleboro rat not related to the local absence of vasopressin. Neurochem. Res 15: 283-288. (Pubitemid 20146713)
13. Feifel, D, Melendez, G, Priebe, K, Shilling, PD (2007) The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav Brain Res 181: 278-286. (Pubitemid 46898666)
14. Feifel, D, Melendez, G, Shilling, PD (2004) Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Neuropsychopharmacology 29: 731-738. (Pubitemid 38402480)
15. Feifel, D, Priebe, K (2001) Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol. Biol Psychiatry 50: 425-433. (Pubitemid 32885592)
16. Geyer, MA, Wilkson, LS, Humby, T, Robbins, TW (1993) Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34: 361-372. (Pubitemid 23295752)
17. Goldman, MB, Mitchell, CP (2004) What is the functional significance of hippocampal pathology in schizophrenia. Schizophr Bull 30: 367-392.
18. Goldman, MB, Robertson, GL, Luchins, DJ, Hedeker, D, Pandey, GN (1997) Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia. Arch Gen Psychiatry 54: 443-449. (Pubitemid 27198206)
19. Green, MF, Kern, RS, Heaton, RK (2004) Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 72: 41-51.
20. lager, AC, Kirch, DG, Bigelow, LB, Karson, CN (1986) Treatment of schizophrenia with a vasopressin analogue. Am J Psychiatry 143: 375-377.
21. Insel, TR, O'Brien, DJ, Leckman, JF (1999) Oxytocin, vasopressin, and autism: is there a connection. Biol Psychiatry 45: 145-157.
22. Jentsch, JD (2003) Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes. J Neurosci 23: 1066-1071.
23. Kelly, BD, O'Callaghan, E, Lane, A, Larkin, C (2003) Schizophrenia: solving the puzzle. Ir J Med Sci 172: 37-40.
24. Legros, JJ, Ansseau, M (1992) Neurohypophyseal peptides and psychopathology. Prog Brain Res 93: 455-460.
25. Matsuoka, T, Sumiyoshi, T, Tanaka, K, Tsunoda, M, Uehara, T, Itoh, H, et al. (2005) NC-1900, an arginine-vasopressin analogue, amelirates social behavior deficits and hyperlocomotion in MK801-treated rats: therapeutic implications for schizophrenia Brain Res 1053: 131-136.
26. McEwen, BB (2004) The roles of vasopressin and oxytocin in memory processing. Adv Pharmacol 50: 103-140.
27. Palkovits, M, Brownstein, MJ (1988) Maps and Guide to Microdissection of the Rat Brain. New York, NY: Elsevier Science Publishing Co., Inc.
28. Ring, RH (2005) The central vasopressinergic system: examining the opportunities for psychiatric drug development. Curr Pharm Des 11: 205-225. (Pubitemid 40089841)
29. Ryan, MC, Thakore, JH (2002) Physical consequences of schizophrenia and its treatment: the metabolic syndrome. Life Sei 71: 239-257. (Pubitemid 34597188)
30. Salum, C, Guimaraes, FS, Bandao, ML, Del Bel, EA (2006) Dopamine and nitric oxide interaction on the modulation of prepulse inhibition of the acoustic startle response in the Wistar rat. Psychopharmacology 185: 133-141. (Pubitemid 43363609)
31. 2c receptor antagonist. Neuropsychopharmacology 30: 372-380.
32. Shilling, PD, Kinhead, B, Murray, T, Melendez, G, Nemeroff, CB, Feifel, D (2006) Upregulation of striatal dopamine-2 receptors in Brattleboro rats with prepulse inhibition deficits. Biol Psychiatry 60: 1278-1281. (Pubitemid 44693532)
33. Smith, JR, Neill, JC, Costall, B (1997) Post-weaning housing conditions influence the behavioural effects of cocaine and d-amphetamine. Psychopharmacology 131: 23-33.
34. Swerdlow, NR, Braff, DL, Taaid, N, Geyer, MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51; 139-153. (Pubitemid 24985903)
35. Tanaka, T, Suzuki, M, Sumiyoshi, T, Murata, M, Tsunoda, M, Kurachi, M (2003) Subchronic phencyclidine administration alters central vasopressin receptor binding and social interaction in the rat, Brain Res 992: 239-245. (Pubitemid 37415106)
36. Varty, GB, Higgins, GA (1995) Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen, antipsychotic drugs. Psychopharmacology 122: 15-26.
37. Walsh, P, Spelman, L, Sharifi, N, Thakore, JH (2005) Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release. Psychoneuroendoerinology 30: 431-437. (Pubitemid 40249809)
38. Wilkinson, LS, Killcross, SS, Humby, T, Hall, FS, Geyer, MA, Robbins, TW (1994) Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology 10: 61-72. (Pubitemid 24074299)
39. Wong, AHC, Van Tol, HHM (2003) Schizophrenia: from phenomenology to neurobiology. Neurosci Biobehav Rev 27: 269-306.