How much insulin does the critical ill need?;Insulinresistenz: Bedeutung in Anästhesie und Intensivmedizin - Wie viel Kalorien und Insulin braucht der kritisch Kranke?

Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie

Volumn 46, Issue 4, 2011, Pages 276-282

  Mayer, Konstantin ^a   Weigand, Markus A ^a   Seeger, Werner ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; CORTICOSTEROID; GLUCOSE; INSULIN;

ARTICLE; CRITICALLY ILL PATIENT; DIET THERAPY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; INSULIN RESPONSE; INSULIN TREATMENT; RISK FACTOR; SURVIVAL RATE;

ANESTHESIA; BLOOD GLUCOSE; CRITICAL ILLNESS; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INTENSIVE CARE; SHOCK, SEPTIC; STRESS, PHYSIOLOGICAL; WATER-ELECTROLYTE IMBALANCE;

EID: 79954520815     PISSN: 09392661     EISSN: 14391074     Source Type: Journal    
DOI: 10.1055/s-0031-1275785     Document Type: Article

References (52)

1. van den Berghe G et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001 345 1359-1367
2. Zerr KJ et al. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg 1997 63 356-361 (Pubitemid 27084552)
3. Brunkhorst FM et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008 358 125-139
4. Brunkhorst FM et al. Intensive insulin therapy in patients with severe sepsis and septic shock is associated with an increased rate of hypoglycemia - results from a randomized multicenter study (VISEP). Infection 2005 33 19-20
5. Annane D et al. Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA 2010 303 341-348
6. Griesdale DE et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 2009 180 821-827
7. Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest 2010 137 544-551
8. Stoner HB et al. The effect of sepsis on the oxidation of carbohydrate and fat. Br J Surg 1983 70 32-35 (Pubitemid 13176026)
9. Gore DC et al. Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 1996 224 97-102 (Pubitemid 26230130)
10. Revelly JP et al. Lactate and glucose metabolism in severe sepsis and cardiogenic shock. Crit Care Med 2005 33 2235-2240
11. Chambrier C et al. Insulin sensitivity of glucose and fat metabolism in severe sepsis. Clin Sci (Lond) 2000 99 321-328
12. Matsuda N et al. Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 2009 37 2791-2799
13. Callahan LA, Supinski GS. Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis. J Appl Physiol 2005 99 1120-1126 (Pubitemid 41214531)
14. Callahan LA, Supinski GS. Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Crit Care Med 2005 172 861-868 (Pubitemid 41369070)
15. Hargrove DM et al. Epinephrine-induced increase in glucose turnover is diminished during sepsis. Metabolism 1989 38 1070-1076 (Pubitemid 19273799)
16. Spitzer JJ et al. Alterations in the metabolic control of carbohydrates in sepsis. Prog Clin Biol Res 1989 308 545-561
17. Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab 2001 15 533-551
18. Mehta VK et al. Low-dose interleukin 1 and tumor necrosis factor individually stimulate insulin release but in combination cause suppression. Eur J Endocrinol 1994 130 208-214 (Pubitemid 24112393)
19. Singer P et al. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 2009 28 387-400
20. Villet S et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr 2005 24 502-509 (Pubitemid 41051903)
21. Faisy C et al. Impact of energy deficit calculated by a predictive method on outcome in medical patients requiring prolonged acute mechanical ventilation. Br J Nutr 2009 101 1079-1087
22. Alberda C et al. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 2009 35 1728-1737
23. Finfer S et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009 360 1283-1297
24. Heyland DK et al. Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 1998 280 2013-2019
25. Peck MD et al. Low protein diets improve survival from peritonitis in guinea pigs. Ann Surg 1989 209 448-454 (Pubitemid 19106276)
26. Alexander JW et al. A new model for studying nutrition in peritonitis. The adverse effect of overfeeding. Ann Surg 1989 209 334-340 (Pubitemid 19083502)
27. Kreymann G et al. DGEM-Leitlinie Enterale Ernährung: Intensivmedizin. Aktuel Ernaehr Med 2003 28
28. Soop M et al. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 2002 282 1276-1285
29. Krogh-Madsen R et al. Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab 2004 286 766-772
30. Cury Boaventura MF et al. Toxicity of a Soybean Oil Emulsion on Human Lymphocytes and Neutrophils. JPEN J Parenter Enteral Nutr 2006 30 115-123
31. Bi MH et al. Induction of lymphocyte apoptosis in a murine model of acute lung injury-modulation by lipid emulsions. Shock 2010 33 179-188
32. Scheiermann P et al. Effects of short-term infusion of lipid emulsions on pro-inflammatory cytokines and lymphocyte apoptosis in septic and non-septic rats. Br J Nutr 2011 27 1-6
33. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006 6 813-822 (Pubitemid 44631650)
34. Elke G et al. Current practice in nutritional support and its association with mortality in septic patients - results from a national, prospective, multicenter study. Crit Care Med 2008 36 1762-1767
35. Devos P et al. Glucose, insulin and myocardial ischaemia. Curr Opin Clin Nutr Metab Care 2006 9 131-139 (Pubitemid 44090037)
36. Howell NJ et al. Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation 2011 123 170-177
37. Kreymann KG et al. [Nutrition of critically ill patients in intensive care]. Internist (Berl) 2007 48 1084-1092 (Pubitemid 350045826)
38. Mentec H et al. Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Crit Care Med 2001 29 1955-1961 (Pubitemid 32980408)
39. Reinhart K et al. [Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI)]. Anaesthesist 2010 59 347-370
40. Moghissi ES et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Endocr Pract 2009 15 353-369
41. Hermanides J et al. Hypoglycemia is associated with intensive care unit mortality. Crit Care Med 2010 38 1430-1434
42. Egi M et al. The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes. Crit Care Med 2011 39 105-111
43. Barr J et al. Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol. Chest 2004 125 1446-1457 (Pubitemid 38501362)
44. Rood E et al. Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc 2005 12 172-180 (Pubitemid 40298952)
45. Eslami S et al. Implementing glucose control in intensive care: a multicenter trial using statistical process control. Intensive Care Med 2010 36 1556-1565
46. Damiani G et al. The effectiveness of computerized clinical guidelines in the process of care: a systematic review. BMC Health Serv Res 2010 10 2-2
47. Chase JG et al. Impact of human factors on clinical protocol performance: a proposed assessment framework and case examples. J Diabetes Sci Technol 2008 2 409-416
48. Meyfroidt G, Keenan at al. Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality. Crit Care Med 2010 38 1021-1029
49. Egi M et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 2010 85 217-224
50. Eslami S et al. Glucose variability measures and their effect on mortality: a systematic review. Intensive Care Med [Epub ahead of print] 2011
51. Bagshaw SM et al. The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care 2009 13
52. Monnier L et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006 295 1681-1687