Sensitivity of natural killer cells to activation in the process of ageing is related to the oxidative and inflammatory status of the elderly

Journal of Physiology and Pharmacology

Volumn 62, Issue 1, 2011, Pages 101-109

  Kaszubowska, Lucyna ^a   Kaczor, J J ^b   Hak, L ^a   Dettlaff Pokora, A ^a   Szarynska, M ^a   Kmiec, Z ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b GDANSK UNIVERSITY OF PHYSICAL EDUCATION AND SPORT   (Poland)

Author keywords

SH groups; Ageing; Inflammatory cytokines; Natural killer cell activation; Nonagenarians; Oxidative stress; Telomerase; Telomeres

Indexed keywords

BIOLOGICAL MARKER; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; TELOMERASE; THIOL GROUP; TUMOR NECROSIS FACTOR ALPHA;

AGED; AGING; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LYMPHOCYTE ACTIVATION; MALE; NATURAL KILLER CELL; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; TELOMERE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANTIOXIDANTS; CYTOKINES; FEMALE; HUMANS; IMMUNITY, INNATE; INFLAMMATION; KILLER CELLS, NATURAL; MALE; OXIDATIVE STRESS; TELOMERASE; TELOMERE;

EID: 79954517252     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Solana R, Alonso MC, Pena J. Natural killer cells in healthy aging. Exp Gerontol 1999; 34: 435-443.
2. Sansoni P, Cossarizza A, Brianti V, et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993; 82: 2767-2773.
3. Sansoni P, Vescovini R, Fagnoni F, et al. The immune system in extreme longevity. Exp Gerontol 2008; 43: 61-65.
4. Kaszubowska L. Telomere shortening and ageing of the immune system. J Physiol Pharmacol 2008; 59(Suppl 9): 169-186.
5. Capri M, Monti D, Salvioli S, et al. Complexity of antiimmunosenescence strategies in humans. Artif Organs 2006; 30: 730-742.
6. Franceschi C, Capri M, Monti D, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128: 92-105.
7. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003; 31: 457-461.
8. Ignatowska-Jankowska B, Jankowski M, Glac W, Swiergiel AH. Cannabidiol-induced lymphopenia does not involve NKT and NK cells. J Physiol Pharmacol 2009; 60(Suppl 3): 99-103.
9. Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine 2000; 18: 1613-1620.
10. Patil S, Schwarer T. Natural killer cells - new understanding of basic biology may lead to more effective allogeneic haematopoietic stem cell transplantation. Intern Med J 2009; 39: 639-647.
11. Mysliwska J, Bryl E, Chodnik T, Foerster J, Mysliwski A. Level of NK cytotoxic activity in the elderly aged more than 80 years. Arch Gerontol Geriatr 1992; 15: 21-28.
12. Mysliwski A, Mysliwska J, Chodnik T, Bigda J, Bryl E, Foerster J. Elderly high NK responders are characterized by intensive proliferative response to PHA and Con Aand optimal health status. Arch Gerontol Geriatr 1993; 16: 199-205.
13. DelaRosa O, Pawelec G, Peralbo E, et al. Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 2006; 7: 471-481.
14. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007; 43: 477-503.
15. Kregel KC, Zhang HJ. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 2007; 292: R18-R36.
16. von Zglinicki T, Martin-Ruiz CM. Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med 2005; 5: 197-203.
17. Ju Z, Rudolph L. Telomere dysfunction and stem cell ageing. Biochimie 2008; 90: 24-32.
18. Richter T, von Zglinicki T. A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 2007; 42: 1039-1042.
19. Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucl Acids Res 2007; 35: 7505-7513.
20. Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ. Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 2008; 44: 235-246.
21. Mariani E, Cornacchiola V, Polidori MC, et al. Antioxidant enzyme activities in healthy old subjects: influence of age, gender and zinc status. Biogerontology 2006; 7: 391-398.
22. Olshansky SJ, Carnes BA, Cassel C. In search of Methuselah: estimating the upper limits to human longevity. Science 1990; 250: 634-640.
23. Bruunsgaard H. Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations. Eur Cytokine Netw 2002; 13: 389-391.
24. Franceschi C. Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev 2007; 65: S173-S176.
25. De la Fuente M, Miquel J. An update of the oxidationinflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des 2009; 15: 3003-3026.
26. Kaszubowska L, Dettlaff-Pokora A, Hak L, et al. Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation. J Physiol Pharmacol 2008; 59(Suppl 9): 187-199.
27. Larsson I, Lundgren E, Nilsson K, Strannegard O. A human neoplastic hematopoietic cell line producing a fibroblast type of interferon. Dev Biol Stand 1979; 42: 193-197.
28. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann NY Acad Sci 2006; 1067: 10-21.
29. Oliveira BF, Nogueira-Machado JA, Chaves MM. The role of oxidative stress in the aging process. ScientificWorldJournal 2010; 10: 1121-1128.
30. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD. Mitochondrial uncoupling and lifespan. Mech Ageing Dev 2010; 131: 463-472.
31. Navarro A, Boveris A. The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 2007; 292: C670-C686.
32. Frisard M, Ravussin E. Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process. Endocrine 2006; 29: 27-32.
33. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84.
34. Goraca A, Ciejka E, Piechota A. Effects of extremely low frequency magnetic field on the parameters of oxidative stress in heart. J Physiol Pharmacol 2010; 61: 333-338.
35. Jones DP. Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res 2006; 9: 169-181.
36. Kakkar P, Singh BK. Mitochondria: a hub of redox activities and cellular distress control. Mol Cell Biochem 2007; 305: 235-253.
37. Markovic J, Borras C, Ortega A, Sastre J, Vina J, Pallardo FV. Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem 2007; 282: 20416-20424.
38. Rebrin I, Sohal RS. Pro-oxidant shift in glutathione redox state during aging. Adv Drug Deliv Rev 2008; 60: 1545-1552.
39. Sohal RS, Mockett RJ, Orr WC. Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radic Biol Med 2002; 33: 575-586.
40. Gil L, Siems W, Mazurek B, et al. Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic Res 2006; 40: 495-505.
41. Chong-Han K. Dietary lipophilic antioxidants: implications and significance in the aging process. Crit Rev Food Sci Nutr 2010; 50: 931-937.
42. Pandey KB, Rizvi SI. Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev 2010; 3: 2-12.
43. Rizwi SI, Maurya PK. Markers of oxidative stress in erythrocytes during aging in humans. Ann NY Acad Sci 2007; 1100: 373-382.
44. Pandey KB, Mehdi MM, Maurya PK, Rizvi SI. Plasma protein oxidation and its correlation with antioxidant potential during human aging. Dis Markers 2010; 29: 31-36.
45. Cakatay U, Kayali R, Uzun H. Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population. Clin Exp Med 2008; 8: 51-57.
46. Rossi P, Marzani B, Giardina S, Negro M, Marzatico F. Human skeletal muscle aging and the oxidative system: cellular events. Curr Aging Sci 2008; 1: 182-191.
47. Fulle S, Di Donna S, Puglielli C, et al. Age-dependent imbalance of the antioxidative system in human satellite cells. Exp Gerontol 2005; 40: 189-197.
48. Droge W, Kinscherf R, Hildebrandt W, Schmitt T. The deficit in low molecular weight thiols as a target for antiageing therapy. Curr Drug Targets 2006; 7: 1505-1512.
49. Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med 1999; 27: 1173-1181.
50. Andriollo-Sanchez M, Hininger-Favier I, Meunier N, et al. Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. Eur J Clin Nutr 2005; 59(Suppl 2): S58-S62.
51. Alho H, Leinonen JS, Erhola M, Lonnrot K, Aejmelaeus R. Assay of antioxidant capacity of human plasma and CSF in aging and disease. Restor Neurol Neurosci 1998; 12: 159-165.
52. Kostka T, Drai J, Berthouze SE, Lacour JR, Bonnefoy M. Physical activity, aerobic capacity and selected markers of oxidative stress and the anti-oxidant defense system in healthy active elderly men. Clin Physiol 2000; 20: 185-190.
53. Sanchez-Rodriguez MA, Retana-Ugalde R, Ruiz-Ramos M, Munoz-Sanchez JL, Vargas-Guadarrama LA, Mendoza- Nuñez VM. Efficient antioxidant capacity against lipid peroxide levels in healthy elderly of Mexico City. Environ Res 2005; 97: 322-329.
54. Mendoza-Nunez VM, Ruiz-Ramos M, Sanchez-Rodriguez MA, Retana-Ugalde R, Munoz-Sanchez JL. Aging-related oxidative stress in healthy humans. Tohoku J Exp Med 2007; 213: 261-268.
55. Paradies G, Petrosillo G, Paradies V, Ruggiero FM. Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging. Free Radic Biol Med 2010; 48: 1286-1295.
56. Mariani E, Meneghetti A, Formentini I, et al. Telomere length and telomerase activity: effect of ageing on human NK cells. Mech Ageing Dev 2003; 124: 403-408.
57. Weng NP, Levine BL, June CH, Hodes RJ. Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996; 183: 2471-2479.
58. Pan C, Xue BH, Ellis TM, Peace DJ, Diaz MO. Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp Cell Res 1997; 231: 346-353.
59. Weng N. Interplay between telomere length and telomerase in human leukocyte differentiation and aging. J Leukoc Biol 2001; 70: 861-867.
60. Lin J-X, Leonard WJ. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 2000; 19: 2566-2576.
61. Dunne J, Lynch S, O'Farrelly C, et al. Selective expansion and partial activation of human NK cells and NK receptorpositive T cells by IL-2 and IL-15. J Immunol 2001; 167: 3129-3138.
62. Young HA, Ortaldo J. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells. Cell Res 2006; 16: 20-24.
63. Gattoni A, Parlato A, Vangieri B, Bresciani M, Derna R. Interferon-gamma: biologic functions and HCV therapy (type I/II). Clin Ter 2006; 157: 377-386.
64. Miyaji C, Watanabe H, Toma H, et al. Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians. Hum Immunol 2000; 61: 908-916.
65. Moretta A, Marcenaro E, Parolini S, Ferlazzo G, Moretta L. NK cells at the interface between innate and adaptive immunity. Cell Death Differ 2008; 15: 226-233.
66. Zhang Y, Wallace DL, de Lara CM, et al. In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology 2007; 121: 258-265.