Effect of 2 Weeks' Consumption of Pomegranate Juice on the Pharmacokinetics of a Single Dose of Midazolam: An Open-Label, Randomized, Single-Center, 2-Period Crossover Study in Healthy Japanese Volunteers

Clinical Therapeutics

Volumn 33, Issue 2, 2011, Pages 246-252

  Misaka, Shingen ^a   Nakamura, Reiko ^b   Uchida, Shinya ^a   Takeuchi, Kazuhiko ^b   Takahashi, Norio ^b   Inui, Naoki ^b   Kosuge, Kazuhiro ^b   Yamada, Shizuo ^a   Watanabe, Hiroshi ^b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CYP3A; Midazolam; Pharmacokinetics; Pomegranate juice

Indexed keywords

ALPHA HYDROXYMIDAZOLAM; CYTOCHROME P450 3A; DRUG METABOLITE; MIDAZOLAM; WATER;

ADULT; ARTICLE; BODY WEIGHT; CONFIDENCE INTERVAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG EXCRETION; FEMALE; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; JAPANESE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; POMEGRANATE JUICE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; URINARY EXCRETION;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BEVERAGES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP3A; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; JAPAN; MALE; METABOLIC CLEARANCE RATE; MIDAZOLAM; PUNICACEAE; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 79954504404     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2011.02.012     Document Type: Article

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