Pharmacokinetics and nephrotoxicity of amphotericin B-incorporated poly(ethylene glycol)-block-poly(N-hexyl stearate l-aspartamide) micelles

Journal of Pharmaceutical Sciences

Volumn 100, Issue 6, 2011, Pages 2064-2070

  Diezi, Thomas A ^a   Takemoto, Jody K ^b   Davies, Neal M ^b   Kwon, Glen S ^a,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c Kyung Hee University   (South Korea)

Author keywords

Amphotericin B; Antifungal agent; Controlled release; Enzymuria; Formulation; Micelle; Nanotechnology; Polymeric drug delivery system; Systemic mycoses

Indexed keywords

AMPHOTERICIN B; GAMMA GLUTAMYLTRANSFERASE; MACROGOL; N ACETYL BETA GLUCOSAMINIDASE; POLY(ETHYLENE GLYCOL) BLOCK POLY(N HEXYL STEARATE ASPARTAMIDE); STEARIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; KIDNEY PARENCHYMA; LIVER; LUNG PARENCHYMA; MALE; MICELLE; NEPHROTOXICITY; NONHUMAN; RAT; TISSUE DISTRIBUTION;

EID: 79954489505     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22445     Document Type: Article

References (18)

1. Saliba F, Dupont B. 2008. Renal impairment and amphotericin B formulations in patients with invasive fungal infections. Med Mycol 46:97-112.
2. Slain D. 1999. Lipid-based amphotericin b for the treatment of fungal infections. Pharmacotherapy 19:306-323.
3. ADAMSML>, ANDES DR, Kwon GS. 2003. Amphotericin b encapsulated in micelles based on poly(ethylene oxide)-block-poly(l-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules 4:750-757.
4. DIEZI TA, Bae YS, Kwon GS. 2010. Enhanced stability of peg-block-poly(n-hexyl stearate l-aspartamide) micelles in the presence of serum proteins. Mol Pharm 7:1355-1360.
5. Lavasanifar A, Samuel J, Kwon GS. 2001. The effect of alkyl core structure on micellar properties of poly(ethylene oxide)-block-poly(l-aspartamide) derivatives. Colloid Surface B 22:115-126.
6. Lavasanifar A, Samuel J, Kwon GS. 2001. Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate l-aspartamide) by a solvent evaporation method: Effect on the solubilization and haemolytic activity of amphotericin B. J Control Release 77:155-160.
7. Vakil R, Kwon GS. 2008. Effect of cholesterol on the release of amphotericin B from PEG-phospholipid micelles. Mol Pharm 5:98-104.
8. Echevarria I, Barturen C, Renedo MJ, Dios-Vieitez MC. 1998. High-performance liquid chromatographic determination of amphotericin B in plasma and tissue. Application to pharmacokinetic and tissue distribution studies in rats. J Chromatogr A 819:171-176.
9. Gershkovich P, Ellen K, Wasan EK, Lin M, Sivak O, Leon CG, Clement JG, Wasan KM. 2009, Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation. J Antimicrob Chemother 64:101-108
10. Bazzi C, Petrini C, Rizza V, Arrigo G, Napodano P, Paparella M, D'Amico G. 2002. Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis. Nephrol Dial Transplant 17:1890-1896.
11. Guder WG, Ross BD. 1984. Enzyme distribution along the nephron. Kidney Int 26:101-111.
12. Bagshaw SM, Langenberg C, Haase M, Wan L, May CN, Bellomo R. 2007. Urinary biomarkers in septic acute kidney injury. Intensive Care Med 33:1285-1296.
13. Inselmann G, Balaschke M, Heidemann HT. 2003. Enzymuria following amphotericin B application in the rat. Mycoses 46:169-173.
14. Tonomura Y, Yamamoto E, Kondo C, Itoh A, Tsuchiya N, Uehara T, Baba T. 2009. Amphotericin B-induced nephrotoxicity: Characterization of blood and urinary biochemistry and renal morphology in mice. Hum Exp Toxicol 28:293-300.
15. Walev I, Bhakdi S. 1996. Possible reason for preferential damage to renal tubular epithelial cells evoked by amphotericin B. Antimicrob Agents Chemother 40:1116-1120.
16. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA. 1995. Vasopressin increases water permeability of kidney collecting duct by inducting translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 92:1013-1017.
17. Kaler B, Morgan W, Bomzon A, Bach PH. 1998. The effects of bile acids on freshly isolated rat glomeruli and proximal tubular fragments. Toxicol In Vitro 12:1-7.
18. Han K, Miah MAJ, Shanmugam S, Yong CS, Choi HG, Kim JA, Yoo BK. 2007. Mixed micellar nanoparticle of amphotericin B and poly styrene-block-poly ethylene oxide reduces nephrotoxicity but retains antifungal activity. Arch Pharm Res 30:1344-1349.