메뉴 건너뛰기




Volumn 46, Issue 2, 2011, Pages 143-152

Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat

Author keywords

dextran sulfate sodium (DSS) colitis; Inflammatory bowel disease (IBD); Mesenchymal stem cell (MSC); Myogenic lineage differentiation; Recovery phase

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; DESMIN; DEXTRAN SULFATE; MESSENGER RNA; NOTCH RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; VIMENTIN;

EID: 79954450326     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0320-7     Document Type: Article
Times cited : (38)

References (39)
  • 1
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • I Okayasu S Hatakeyama M Yamada T Ohkusa Y Inagaki R Nakaya 1990 A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 694 702 1:STN:280:DyaK3c7ivVSnuw%3D%3D 1688816 (Pubitemid 20069706)
    • (1990) Gastroenterology , vol.98 , Issue.3 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 2
    • 0016619394 scopus 로고
    • Experimental ulcerative disease of the colon
    • 1:STN:280:DyaE28%2FnsV2rsQ%3D%3D 1202321
    • J Watt R Marcus 1975 Experimental ulcerative disease of the colon Methods Achiev Exp Pathol 7 56 71 1:STN:280:DyaE28%2FnsV2rsQ%3D%3D 1202321
    • (1975) Methods Achiev Exp Pathol , vol.7 , pp. 56-71
    • Watt, J.1    Marcus, R.2
  • 3
    • 0033768784 scopus 로고    scopus 로고
    • Characterization of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
    • 1:CAS:528:DC%2BD3cXoslWju70%3D 10.1159/000007822 11070407
    • B Egger M Bajaj-Elliott TT MacDonald R Inglin VE Eysselein MW Buchler 2000 Characterization of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency Digestion 62 240 248 1:CAS:528:DC%2BD3cXoslWju70%3D 10.1159/000007822 11070407
    • (2000) Digestion , vol.62 , pp. 240-248
    • Egger, B.1    Bajaj-Elliott, M.2    MacDonald, T.T.3    Inglin, R.4    Eysselein, V.E.5    Buchler, M.W.6
  • 4
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • 1:CAS:528:DyaK2cXhs1Smtr0%3D 8350599
    • HS Cooper SNS Murthy RS Shah DJ Sedergran 1993 Clinicopathologic study of dextran sulfate sodium experimental murine colitis Lab Invest 69 238 249 1:CAS:528:DyaK2cXhs1Smtr0%3D 8350599
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.S.2    Shah, R.S.3    Sedergran, D.J.4
  • 5
    • 40049097099 scopus 로고    scopus 로고
    • Epithelial restitution and wound healing in inflammatory bowel disease
    • DOI 10.3748/wjg.14.348
    • A Sturm AU Dignass 2008 Epithelial restitution and wound healing in inflammatory bowel disease World J Gastroenterol 14 348 353 1:CAS:528: DC%2BD1cXjvFKkt70%3D 10.3748/wjg.14.348 18200658 (Pubitemid 351320844)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 348-353
    • Sturm, A.1    Dignass, A.U.2
  • 6
    • 0041837509 scopus 로고    scopus 로고
    • Trefoil factors: Initiators of mucosal healing
    • DOI 10.1038/nrm1203
    • D Taupin DK Podolsky 2003 Trefoil factors: initiators of mucosal healing Nat Rev Mol Cell Biol 4 721 732 1:CAS:528:DC%2BD3sXnsVKqsLY%3D 10.1038/nrm1203 14506475 (Pubitemid 37082187)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.9 , pp. 721-732
    • Taupin, D.1    Podolsky, D.K.2
  • 7
    • 0028231686 scopus 로고
    • Fibroblast growth factors modulate intestinal epithelial cell growth and migration
    • AU Dignass S Tsunekawa DK Podolsky 1994 Fibroblast growth factors modulate intestinal epithelial cell growth and migration Gastroenterology 106 1254 1262 1:STN:280:DyaK2c3ivFCltw%3D%3D 7513666 (Pubitemid 24129242)
    • (1994) Gastroenterology , vol.106 , Issue.5 , pp. 1254-1262
    • Dignass, A.U.1    Tsunekawa, S.2    Podolsky, D.K.3
  • 8
    • 39749092525 scopus 로고    scopus 로고
    • Current view: Intestinal stem cells and signaling
    • DOI 10.1053/j.gastro.2008.01.079, PII S0016508508001856
    • DH Scoville T Sato XC He L Li 2008 Current view: intestinal stem cells and signaling Gastroenterology 134 849 864 1:CAS:528:DC%2BD1cXktlehtb0%3D 10.1053/j.gastro.2008.01.079 18325394 (Pubitemid 351312767)
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 9
    • 0035123651 scopus 로고    scopus 로고
    • Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
    • KL Williams CR Fuller LA Dieleman CM DaCosta KM Haldeman RB Sartor, et al. 2001 Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone Gastroenterology 120 925 937 1:CAS:528:DC%2BD3MXitlertL4%3D 10.1053/gast.2001. 22470 11231946 (Pubitemid 32193189)
    • (2001) Gastroenterology , vol.120 , Issue.4 , pp. 925-937
    • Williams, K.L.1    Fuller C.Randall2    Dieleman, L.A.3    DaCosta, C.M.4    Haldeman, K.M.5    Sartor R.Balfour6    Lund P.Kay7
  • 13
    • 20444473689 scopus 로고    scopus 로고
    • A regenerative role for bone marrow following experimental colitis: Contribution to neovasculogenesis and myofibroblasts
    • DOI 10.1053/j.gastro.2005.03.028, PII S0016508505004452
    • M Brittan V Chance G Elia R Poulsom MR Alison TT MacDonald, et al. 2005 A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts Gastroenterology 128 1984 1995 10.1053/j.gastro.2005.03.028 15940631 (Pubitemid 40824707)
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1984-1995
    • Brittan, M.1    Chance, V.2    Elia, G.3    Poulsom, R.4    Alison, M.R.5    MacDonald, T.T.6    Wright, N.A.7
  • 14
    • 0036100750 scopus 로고    scopus 로고
    • Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
    • DOI 10.1136/gut.50.6.752
    • M Brittan T Hunt R Jeffery R Poulsom SJ Forbes K Hodivala-Dilke, et al. 2002 Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon Gut 50 752 757 1:STN:280:DC%2BD383psFWnsg%3D%3D 10.1136/gut.50.6.752 12010874 (Pubitemid 34539034)
    • (2002) Gut , vol.50 , Issue.6 , pp. 752-757
    • Brittan, M.1    Hunt, T.2    Jeffery, R.3    Poulsom, R.4    Forbes, S.J.5    Hodivala-Dilke, K.6    Goldman, J.7    Alison, M.R.8    Wright, N.A.9
  • 16
    • 35048816566 scopus 로고    scopus 로고
    • The transdifferentiation of bone-marrow-derived cells in colonic mucosal regeneration after dextran-sulfate-sodium-induced colitis in mice
    • DOI 10.1159/000104148
    • Y Hayashi S Tsuji M Tsujii T Nishida S Ishii T Nakamura, et al. 2007 The transdifferentiation of bone-marrow-derived cells in colonic mucosal regeneration after dextran-sulfate-sodium-induced colitis in mice Pharmacology 80 193 199 1:CAS:528:DC%2BD2sXhtFKhsb7N 10.1159/000104148 17587885 (Pubitemid 47557252)
    • (2007) Pharmacology , vol.80 , Issue.4 , pp. 193-199
    • Hayashi, Y.1    Tsuji, S.2    Tsujii, M.3    Nishida, T.4    Ishii, S.5    Nakamura, T.6    Eguchi, H.7    Kawano, S.8
  • 18
    • 34247631655 scopus 로고    scopus 로고
    • Inducible Nitric Oxide Synthase From Bone Marrow-Derived Cells Plays a Critical Role in Regulating Colonic Inflammation
    • DOI 10.1053/j.gastro.2007.01.032, PII S0016508507001679
    • PL Beck Y Li J Wong CW Chen CM Keenan KA Sharkey, et al. 2007 Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation Gastroenterology 132 1778 1790 1:CAS:528:DC%2BD2sXmsVyms7g%3D 10.1053/j.gastro.2007.01.032 17449036 (Pubitemid 46677932)
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1778-1790
    • Beck, P.L.1    Li, Y.2    Wong, J.3    Chen, C.4    Keenan, C.M.5    Sharkey, K.A.6    McCafferty, D.7
  • 19
    • 67650093720 scopus 로고    scopus 로고
    • Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity
    • 1:CAS:528:DC%2BD1MXoslOktL8%3D 10.1002/path.2535 19291714
    • T Yabana Y Arimura H Tanaka A Goto M Hosokawa K Nagaishi, et al. 2009 Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity J Pathol 218 350 359 1:CAS:528:DC%2BD1MXoslOktL8%3D 10.1002/path.2535 19291714
    • (2009) J Pathol , vol.218 , pp. 350-359
    • Yabana, T.1    Arimura, Y.2    Tanaka, H.3    Goto, A.4    Hosokawa, M.5    Nagaishi, K.6
  • 20
    • 47949120741 scopus 로고    scopus 로고
    • Topical implantation of Mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats
    • 1:CAS:528:DC%2BD1cXpsVWqs78%3D 10.1124/jpet.108.137083 18448866
    • Y Hayashi S Tsuji M Tsuji M Tsujii T Nishida H Iijima, et al. 2008 Topical implantation of Mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats J Pharmacol Exp Ther 326 523 531 1:CAS:528:DC%2BD1cXpsVWqs78%3D 10.1124/jpet.108.137083 18448866
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 523-531
    • Hayashi, Y.1    Tsuji, S.2    Tsuji, M.3    Tsujii, M.4    Nishida, T.5    Iijima, H.6
  • 21
    • 46049092017 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats
    • DOI 10.1002/ibd.20382
    • Y Ando M Inaba Y Sakaguchi M Tsuda GK Quan M Omae, et al. 2008 Subcutaneous Adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats Inflamm Bowel Dis 14 826 838 10.1002/ibd.20382 18253953 (Pubitemid 351898068)
    • (2008) Inflammatory Bowel Diseases , vol.14 , Issue.6 , pp. 826-838
    • Ando, Y.1    Inaba, M.2    Sakaguchi, Y.3    Tsuda, M.4    Guo, K.Q.5    Omae, M.6    Okazaki, K.7    Ikehara, S.8
  • 22
    • 33947307177 scopus 로고    scopus 로고
    • Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease
    • DOI 10.1053/j.gastro.2006.12.029, PII S0016508506026795
    • PN Khalil V Weiler PJ Nelson MN Khalil S Moosmann WE Mutschler, et al. 2007 Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease Gastroenterology 132 944 954 10.1053/j.gastro.2006.12.029 17383423 (Pubitemid 46440862)
    • (2007) Gastroenterology , vol.132 , Issue.3 , pp. 944-954
    • Khalil, P.N.1    Weiler, V.2    Nelson, P.J.3    Khalil, M.N.4    Moosmann, S.5    Mutschler, W.E.6    Siebeck, M.7    Huss, R.8
  • 23
    • 76249084930 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
    • 1:CAS:528:DC%2BD1MXhsFCkt7vP 10.4049/jimmunol.0902318 19923445
    • Q Zhang S Shi Y Liu J Uyanne Y Shi AD Le 2009 Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis J Immunol 183 7787 7798 1:CAS:528:DC%2BD1MXhsFCkt7vP 10.4049/jimmunol.0902318 19923445
    • (2009) J Immunol , vol.183 , pp. 7787-7798
    • Zhang, Q.1    Shi, S.2    Liu, Y.3    Uyanne, J.4    Shi, Y.5    Le, A.D.6
  • 24
    • 60449093316 scopus 로고    scopus 로고
    • Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
    • 1:CAS:528:DC%2BD1MXovFSktb8%3D 10.1136/gut.2008.168534 19136511
    • E Gonzalez-Rey P Anderson MA González L Rico D Buscher M Delgado 2009 Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis Gut 58 929 939 1:CAS:528:DC%2BD1MXovFSktb8%3D 10.1136/gut.2008.168534 19136511
    • (2009) Gut , vol.58 , pp. 929-939
    • Gonzalez-Rey, E.1    Anderson, P.2    González, M.A.3    Rico, L.4    Buscher, D.5    Delgado, M.6
  • 25
    • 55749112995 scopus 로고    scopus 로고
    • Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    • 1:CAS:528:DC%2BD1cXhtlylu7vF 10.1016/j.lfs.2008.09.016 18950645
    • F Tanaka K Tominaga M Ochi T Tanigawa T Watanabe Y Fujiwara, et al. 2008 Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats Life Sci 83 771 779 1:CAS:528:DC%2BD1cXhtlylu7vF 10.1016/j.lfs.2008.09.016 18950645
    • (2008) Life Sci , vol.83 , pp. 771-779
    • Tanaka, F.1    Tominaga, K.2    Ochi, M.3    Tanigawa, T.4    Watanabe, T.5    Fujiwara, Y.6
  • 27
    • 0034994682 scopus 로고    scopus 로고
    • Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells
    • EH Javazon DC Colter EJ Schwarz DJ Prockop 2001 Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells Stem Cells 19 219 225 1:STN:280:DC%2BD3M3ns1Cgtw%3D%3D 10.1634/stemcells.19-3-219 11359947 (Pubitemid 32524543)
    • (2001) Stem Cells , vol.19 , Issue.3 , pp. 219-225
    • Javazon, E.H.1    Colter, D.C.2    Schwarz, E.J.3    Prockop, D.J.4
  • 28
    • 0037240649 scopus 로고    scopus 로고
    • Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate MSC-like cells from umbilical cord
    • YA Romanov VA Svintsitskaya VN Smirnov 2003 Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-Like cells from umbilical cord Stem Cells 21 105 110 10.1634/stemcells.21-1-105 12529557 (Pubitemid 36120371)
    • (2003) Stem Cells , vol.21 , Issue.1 , pp. 105-110
    • Romanov, Y.A.1    Svintsitskaya, V.A.2    Smirnov, V.N.3
  • 29
    • 0034802566 scopus 로고    scopus 로고
    • Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats
    • DOI 10.1053/jhep.2001.28231
    • H Yoshiji S Kuriyama J Yoshii Y Ikenaka R Noguchi T Nakatani, et al. 2001 Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats Hepatology 34 745 750 1:CAS:528: DC%2BD3MXns1Kisrs%3D 10.1053/jhep.2001.28231 11584371 (Pubitemid 32927999)
    • (2001) Hepatology , vol.34 , Issue.4 I , pp. 745-750
    • Yoshiji, H.1    Kuriyama, S.2    Yoshii, J.3    Ikenaka, Y.4    Noguchi, R.5    Nakatani, T.6    Tsujinoue, H.7    Fukui, H.8
  • 30
    • 0030890344 scopus 로고    scopus 로고
    • A novel monoclonal antibody, RM-4, specifically recognizes rat macrophages and dendritic cells in formalin-fixed, paraffin-embedded tissues
    • K Iyonaga M Takeya T Yamamoto M Ando K Takahashi 1997 A novel monoclonal antibody, RM-4, specifically recognizes rat macrophages and dendritic cells in formalin-fixed, paraffin-embedded tissues Histochem J 29 105 116 1:CAS:528:DyaK2sXjtVOgsb8%3D 10.1023/A:1026477104227 9147067 (Pubitemid 27192185)
    • (1997) Histochemical Journal , vol.29 , Issue.2 , pp. 105-116
    • Iyonaga, K.1    Takeya, M.2    Yamamoto, T.3    Ando, M.4    Takahashi, K.5
  • 31
    • 33846001022 scopus 로고    scopus 로고
    • Wound healing and fibrosis in intestinal disease
    • DOI 10.1136/gut.2006.090456
    • F Rieder J Brenmoehl S Leeb, et al. 2007 Wound healing and fibrosis in intestinal disease Gut 56 130 139 1:CAS:528:DC%2BD2sXhtF2qsbw%3D 10.1136/gut.2006.090456 17172588 (Pubitemid 46044899)
    • (2007) Gut , vol.56 , Issue.1 , pp. 130-139
    • Rieder, F.1    Brenmoehl, J.2    Leeb, S.3    Scholmerich, J.4    Rogler, G.5
  • 32
    • 0028954548 scopus 로고
    • Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology
    • 1:STN:280:DyaK2M7jslartg%3D%3D 10.1016/0016-5085(95)90087-X 7835600
    • JA Barnard RD Beauchamp WE Russell J Scholmerich G Rogler, et al. 1995 Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology Gastroenterology 108 564 580 1:STN:280:DyaK2M7jslartg%3D%3D 10.1016/0016-5085(95)90087-X 7835600
    • (1995) Gastroenterology , vol.108 , pp. 564-580
    • Barnard, J.A.1    Beauchamp, R.D.2    Russell, W.E.3    Scholmerich, J.4    Rogler, G.5
  • 33
    • 0036196146 scopus 로고    scopus 로고
    • Effects of TGF-α gene Knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine
    • DOI 10.1002/jcp.10079
    • CJ Xian JC Cool GS Howarth LC Read 2002 Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine J Cell Physiol 191 105 115 1:CAS:528: DC%2BD38XitFSrsrk%3D 10.1002/jcp.10079 11920686 (Pubitemid 34195222)
    • (2002) Journal of Cellular Physiology , vol.191 , Issue.1 , pp. 105-115
    • Xian, C.J.1    Cool, J.C.2    Howarth, G.S.3    Read, L.C.4
  • 34
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • DOI 10.1126/science.1065718
    • Q Yang NA Bermingham MJ Finegold HY Zoghbi 2001 Requirement of Math1 for secretory cell lineage commitment in the mouse intestine Science 294 2155 2158 1:CAS:528:DC%2BD3MXptVOmsLk%3D 10.1126/science.1065718 11739954 (Pubitemid 33150670)
    • (2001) Science , vol.294 , Issue.5549 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 36
    • 60449100851 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    • 10.1053/j.gastro.2008.11.041 19135996
    • MA González E Gonzalez-Rey L Rico D Buscher M Delgado 2009 Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses Gastroenterology 136 978 989 10.1053/j.gastro.2008.11.041 19135996
    • (2009) Gastroenterology , vol.136 , pp. 978-989
    • González, M.A.1    Gonzalez-Rey, E.2    Rico, L.3    Buscher, D.4    Delgado, M.5
  • 37
    • 67651052481 scopus 로고    scopus 로고
    • Comparison of the population capacity of hematopoietic and mesenchymal stem cells in experimental colitis rat model
    • 10.1097/TP.0b013e3181a9f0a7 19584679
    • Y Wei Y Nie J Lai YJ Wan Y Li 2009 Comparison of the population capacity of hematopoietic and mesenchymal stem cells in experimental colitis rat model Transplantation 88 42 48 10.1097/TP.0b013e3181a9f0a7 19584679
    • (2009) Transplantation , vol.88 , pp. 42-48
    • Wei, Y.1    Nie, Y.2    Lai, J.3    Wan, Y.J.4    Li, Y.5
  • 39
    • 0036076884 scopus 로고    scopus 로고
    • Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells
    • DOI 10.1006/excr.2002.5561
    • B Kinner JM Zaleskas M Spector 2002 Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells Exp Cell Res 278 72 83 1:CAS:528:DC%2BD38XltFKiur8%3D 10.1006/excr.2002.5561 12126959 (Pubitemid 34775447)
    • (2002) Experimental Cell Research , vol.278 , Issue.1 , pp. 72-83
    • Kinner, B.1    Zaleskas, J.M.2    Spector, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.