The dynamic stress-induced "o-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways

Amino Acids

Volumn 40, Issue 3, 2011, Pages 793-808

  Zachara, Natasha E ^a,b   Molina, Henrik ^a,c   Wong, Ker Yi ^b   Pandey, Akhilesh ^a,c   Hart, Gerald W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins Singapore   (Singapore)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cell stress; Cellular stress; Chaperone; Glycosylation; O GlcNAc; Signal transduction

Indexed keywords

AMINO ACID; CARRIER PROTEIN; COPII VESICLE TRANSPORT PROTEIN; DOUBLE STRANDED DNA; N ACETYLGLUCOSAMINE; NF 90 PROTEIN; PROTEIN KINASE; RUVB LIKE 1 PROTEIN; RUVB LIKE 2 PROTEIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CELL CULTURE; CELL STRAIN COS7; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; HEAT SHOCK; ISOTOPE LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION;

ACETYLGLUCOSAMINE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA DAMAGE; DNA REPAIR; GLYCOSYLATION; PROTEINS; STRESS, PHYSIOLOGICAL;

METAZOA;

EID: 79954434103     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0695-z     Document Type: Article

References (97)

1. Amanchy R, Kalume DE, Pandey A (2005) Stable isotope labeling with amino acids in cell culture (SILAC) for studying dynamics of protein abundance and posttranslational modifications. Sci STKE 2005, p l2
2. G Amodio M Renna S Paladino C Venturi C Tacchetti O Moltedo S Franceschelli M Mallardo S Bonatti P Remondelli 2009 Endoplasmic reticulum stress reduces the export from the ER and alters the architecture of post-ER compartments Int J Biochem Cell Biol 41 2511 2521 1:CAS:528:DC%2BD1MXhtlGhsrrJ 10.1016/j.biocel.2009.08.006 19695339
3. FD Barr LJ Krohmer JW Hamilton LA Sheldon 2009 Disruption of histone modification and CARM1 recruitment by arsenic represses transcription at glucocorticoid receptor-regulated promoters PLoS One 4 e6766 10.1371/journal.pone.0006766 19707557
4. Bauer I, Graessle S, Loidl P, Hohenstein K, Brosch G (2010) Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans. Fungal Genet Biol
5. E Belles-Boix E Babiychuk MV Montagu D Inze S Kushnir 2000 CEF, a sec24 homologue of Arabidopsis thaliana, enhances the survival of yeast under oxidative stress conditions J Exp Bot 51 1761 1762 1:CAS:528: DC%2BD3cXotVWis7Y%3D 10.1093/jexbot/51.351.1761 11053466
6. V Champattanachai RB Marchase JC Chatham 2007 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc Am J Physiol Cell Physiol 292 C178 C187 1:CAS:528:DC%2BD2sXisFCrtbY%3D 10.1152/ajpcell.00162.2006 16899550 (Pubitemid 46115129)
7. V Champattanachai RB Marchase JC Chatham 2008 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2 Am J Physiol Cell Physiol 294 C1509 C1520 1:CAS:528:DC%2BD1cXnsVGgs74%3D 10.1152/ajpcell.00456.2007 18367586
8. JC Chatham LG Not N Fulop RB Marchase 2008 Hexosamine biosynthesis and protein O-glycosylation: the first line of defense against stress, ischemia, and trauma Shock 29 431 440 1:CAS:528:DC%2BD1cXkvVarsr0%3D 17909453 (Pubitemid 351416795)
9. SL Chen KA Loffler D Chen MR Stallcup GE Muscat 2002 The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2 J Biol Chem 277 4324 4333 1:CAS:528:DC%2BD38XhsFSqsLk%3D 10.1074/jbc.M109835200 11713257 (Pubitemid 34968698)
10. D Cheng J Cote S Shaaban MT Bedford 2007 The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing Mol Cell 25 71 83 10.1016/j.molcel.2006.11.019 17218272 (Pubitemid 46049059)
11. Y Cheng X Liu S Zhang Y Lin J Yang C Zhang 2009 MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4 J Mol Cell Cardiol 47 5 14 1:CAS:528:DC%2BD1MXms1Ortrs%3D 10.1016/j.yjmcc.2009.01.008 19336275
12. WD Cheung GW Hart 2008 AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation J Biol Chem 283 13009 13020 1:CAS:528:DC%2BD1cXltlGrt7c%3D 10.1074/jbc.M801222200 18353774
13. WD Cheung K Sakabe MP Housley WB Dias GW Hart 2008 O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins J Biol Chem 283 33935 33941 1:CAS:528:DC%2BD1cXhsVelu7%2FP 10.1074/jbc.M806199200 18840611
14. KP Choe K Strange 2007 Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans Am J Physiol Cell Physiol 293 C915 C927 1:CAS:528:DC%2BD2sXhtVOqsLbL 10.1152/ajpcell.00126.2007 17596296 (Pubitemid 47437372)
15. TY Chou GW Hart CV Dang 1995 c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas J Biol Chem 270 18961 18965 1:CAS:528:DyaK2MXnsVOju74%3D 10.1074/jbc.270.32.18961 7642555
16. FI Comer GW Hart 1996 Investigating the role of O-GlcNAc on RNA polymerase II FASEB J 10 6 A1110 A1119
17. N Crampton M Kodiha S Shrivastava R Umar U Stochaj 2009 Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1 Mol Biol Cell 20 5106 5116 1:CAS:528:DC%2BC3cXnslam 10.1091/mbc.E09-05-0397 19828735
18. S El Messaoudi E Fabbrizio C Rodriguez P Chuchana L Fauquier D Cheng C Theillet L Vandel MT Bedford C Sardet 2006 Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene Proc Natl Acad Sci USA 103 13351 13356 1:CAS:528:DC%2BD28XpvVals7c%3D 10.1073/pnas.0605692103 16938873 (Pubitemid 44380111)
19. Y Fu A Subramanya D Rozansky DM Cohen 2006 WNK kinases influence TRPV4 channel function and localization Am J Physiol Renal Physiol 290 F1305 F1314 1:CAS:528:DC%2BD28XlvVersL8%3D 10.1152/ajprenal.00391.2005 16403833 (Pubitemid 43830754)
20. N Fulop RB Marchase JC Chatham 2007 Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system Cardiovasc Res 73 288 297 10.1016/j.cardiores.2006.07.018 16970929 (Pubitemid 44937687)
21. Fulop N, Zhang Z, Marchase RB, Chatham JC (2007b) Glucosamine cardioprotection in perfused rat heart associated with increased O-Linked N-acetylglucosamine protein modification and altered p38 activation. Am J Physiol Heart Circ Physiol
22. N Fulop Z Zhang RB Marchase JC Chatham 2007 Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation Am J Physiol Heart Circ Physiol 292 H2227 H2236 1:CAS:528:DC%2BD2sXlslSiu78%3D 10.1152/ajpheart.01091.2006 17208994 (Pubitemid 47084603)
23. MC Gambetta K Oktaba J Muller 2009 Essential role of the glycosyltransferase sxc/Ogt in polycomb repression Science 325 93 96 1:CAS:528:DC%2BD1MXnvF2kt70%3D 10.1126/science.1169727 19478141
24. LS Griffith B Schmitz 1995 O-linked N-acetylglucosamine is upregulated in Alzheimer brains Biochem Biophys Res Commun 213 424 431 1:CAS:528: DyaK2MXnsFKitrY%3D 10.1006/bbrc.1995.2149 7646495
25. LS Griffith B Schmitz 1999 O-linked N-acetylglucosamine levels in cerebellar neurons respond reciprocally to pertubations of phosphorylation Eur J Biochem 262 824 831 1:CAS:528:DyaK1MXkt1yrurc%3D 10.1046/j.1432-1327.1999. 00439.x 10411645 (Pubitemid 29291041)
26. C Guinez AM Mir V Dehennaut R Cacan A Harduin-Lepers JC Michalski T Lefebvre 2008 Protein ubiquitination is modulated by O-GlcNAc glycosylation FASEB J 22 2901 2911 1:CAS:528:DC%2BD1cXpsVygtr8%3D 10.1096/fj.07-102509 18434435
27. HC Harsha H Molina A Pandey 2008 Quantitative proteomics using stable isotope labeling with amino acids in cell culture Nat Protoc 3 505 516 1:CAS:528:DC%2BD1cXivFyktbw%3D 10.1038/nprot.2008.2 18323819 (Pubitemid 351372235)
28. GW Hart MP Housley C Slawson 2007 Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins Nature 446 1017 1022 1:CAS:528:DC%2BD2sXksFersr4%3D 10.1038/nature05815 17460662 (Pubitemid 46676063)
29. C Heilig F Brosius B Siu L Concepcion R Mortensen K Heilig M Zhu R Weldon G Wu D Conner 2003 Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress Am J Pathol 163 1873 1885 1:CAS:528:DC%2BD3sXpsVWltLY%3D 10.1016/S0002-9440(10)63546-8 14578187 (Pubitemid 37310018)
30. A Hoorens M Van de Casteele G Klöppel D Pipeleers 1996 Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program JClin Invest 98 1568 1574 1:CAS:528:DyaK28XmtVCmu7g%3D 10.1172/JCI118950 (Pubitemid 26327866)
31. N Ibarrola DE Kalume M Gronborg A Iwahori A Pandey 2003 A proteomic approach for quantitation of phosphorylation using stable isotope labeling in cell culture Anal Chem 75 6043 6049 1:CAS:528:DC%2BD3sXnvFOjurc%3D 10.1021/ac034931f 14615979 (Pubitemid 37420592)
32. S Jha A Dutta 2009 RVB1/RVB2: running rings around molecular biology Mol Cell 34 521 533 1:CAS:528:DC%2BD1MXpsFCnu78%3D 10.1016/j.molcel.2009.05.016 19524533
33. SP Jones NE Zachara GA Ngoh BG Hill Y Teshima A Bhatnagar GW Hart E Marban 2008 Cardioprotection by N-acetylglucosamine linkage to cellular proteins Circulation 117 1172 1182 1:CAS:528:DC%2BD1cXitlyrsL8%3D 10.1161/ CIRCULATIONAHA.107.730515 18285568 (Pubitemid 351544067)
34. K Kamemura GW Hart 2003 Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription Prog Nucleic Acid Res Mol Biol 73 107 136 1:CAS:528:DC%2BD3sXntVSqs7Y%3D 10.1016/S0079-6603(03)01004-3 12882516 (Pubitemid 137639541)
35. M Kodiha D Tran A Morogan C Qian U Stochaj 2009 Dissecting the signaling events that impact classical nuclear import and target nuclear transport factors PLoS One 4 e8420 10.1371/journal.pone.0008420 20041180
36. R Kulshreshtha M Ferracin M Negrini GA Calin RV Davuluri M Ivan 2007 Regulation of microRNA expression: the hypoxic component Cell Cycle 6 1426 1431 1:CAS:528:DC%2BD2sXhtVaks7rO 10.4161/cc.6.12.4410 17582223
37. R Kulshreshtha M Ferracin SE Wojcik R Garzon H Alder FJ Agosto-Perez R Davuluri CG Liu CM Croce M Negrini, et al. 2007 A microRNA signature of hypoxia Mol Cell Biol 27 1859 1867 1:CAS:528:DC%2BD2sXit1Wgurs%3D 10.1128/MCB.01395-06 17194750
38. B Laczy BG Hill K Wang AJ Paterson CR White D Xing YF Chen V Darley-Usmar S Oparil JC Chatham 2009 Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system Am J Physiol Heart Circ Physiol 296 H13 H28 1:CAS:528:DC%2BD1MXhtVOiurY%3D 10.1152/ajpheart.01056.2008 19028792
39. JO Langland PN Kao BL Jacobs 1999 Nuclear factor-90 of activated T-cells: a double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR Biochemistry 38 6361 6368 1:CAS:528: DyaK1MXisFGns7g%3D 10.1021/bi982410u 10320367 (Pubitemid 29230257)
40. T Lefebvre C Alonso S Mahboub MJ Dupire JP Zanetta ML Caillet-Boudin JC Michalski 1999 Effect of okadaic acid on O-linked N-acetylglucosamine levels in a neuroblastoma cell line Biochim Biophys Acta 1472 71 81 1:CAS:528: DyaK1MXnsFSrs7g%3D 10572927 (Pubitemid 29486516)
41. T Lefebvre S Ferreira L Dupont-Wallois T Bussiere MJ Dupire A Delacourte JC Michalski ML Caillet-Boudin 2003 Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins-a role in nuclear localization Biochim Biophys Acta 1619 167 176 1:CAS:528:DC%2BD3sXjt1SgtA%3D%3D 12527113 (Pubitemid 36078354)
42. AK Leung JM Calabrese PA Sharp 2006 Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules Proc Natl Acad Sci USA 103 18125 18130 1:CAS:528:DC%2BD28XhtlWjt7zP 10.1073/pnas. 0608845103 17116888 (Pubitemid 44871623)
43. KH Lim HI Chang 2006 O-linked N-acetylglucosamine suppresses thermal aggregation of Sp1 FEBS Lett 580 4645 4652 1:CAS:528:DC%2BD28XotV2gu7c%3D 10.1016/j.febslet.2006.07.040 16879824 (Pubitemid 44189383)
44. J Liu Y Pang T Chang P Bounelis JC Chatham RB Marchase 2006 Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia J Mol Cell Cardiol 40 303 312 1:CAS:528:DC%2BD28XhtFSgsrg%3D 10.1016/j.yjmcc.2005.11.003 16337959 (Pubitemid 43152386)
45. J Liu RB Marchase JC Chatham 2007 Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis Am J Physiol Heart Circ Physiol 293 H1391 H1399 1:CAS:528:DC%2BD2sXhtVOqtr%2FN 10.1152/ajpheart.00285.2007 17573462 (Pubitemid 47367181)
46. RD Loberg E Vesely FC Brosius III 2002 Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism J Biol Chem 277 41667 41673 1:CAS:528:DC%2BD38XotF2gsrk%3D 10.1074/jbc.M206405200 12200436 (Pubitemid 35257473)
47. R Malhotra FC Brosius 3rd 1999 Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes J Biol Chem 274 12567 12575 1:CAS:528:DyaK1MXjtFGgu7o%3D 10.1074/jbc.274.18.12567 10212235 (Pubitemid 29215492)
48. CJ Marsit K Eddy KT Kelsey 2006 MicroRNA responses to cellular stress Cancer Res 66 10843 10848 1:CAS:528:DC%2BD2sXivVyqsbo%3D 10.1158/0008-5472.CAN- 06-1894 17108120 (Pubitemid 44876980)
49. KH Moley MM Mueckler 2000 Glucose transport and apoptosis Apoptosis 5 99 105 1:CAS:528:DC%2BD3cXkvFOmtrg%3D 10.1023/A:1009697908332 11232248 (Pubitemid 30399383)
50. B Musicki MF Kramer RE Becker AL Burnett 2005 Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction Proc Natl Acad Sci USA 102 11870 11875 1:CAS:528:DC%2BD2MXpsFGgur8%3D 10.1073/pnas.0502488102 16085713 (Pubitemid 41170817)
51. T Nagy V Champattanachai RB Marchase JC Chatham 2006 Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2 + elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine Am J Physiol Cell Physiol 290 C57 C65 1:CAS:528:DC%2BD28XhsVSjtbc%3D 10.1152/ajpcell.00263.2005 16107505
52. GA Ngoh SP Jones 2008 New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine J Pharmacol Exp Ther 327 602 609 1:CAS:528:DC%2BD1cXhsVCjtL3E 10.1124/jpet.108.143263 18768779
53. GA Ngoh LJ Watson HT Facundo W Dillmann SP Jones 2008 Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition J Mol Cell Cardiol 45 313 325 1:CAS:528:DC%2BD1cXhtVSjs7fI 10.1016/j.yjmcc.2008.04.009 18539296
54. GA Ngoh HT Facundo T Hamid W Dillmann NE Zachara SP Jones 2009 Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury Circ Res 104 41 49 1:CAS:528:DC%2BD1cXhsFSmt77F 10.1161/CIRCRESAHA.108.189431 19023128
55. Not LG, Marchase RB, Fulop N, Brocks CA, Chatham JC (2007) Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats. Shock
56. T Ohn N Kedersha T Hickman S Tisdale P Anderson 2008 A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly Nat Cell Biol 10 1224 1231 1:CAS:528:DC%2BD1cXhtFyqur3E 10.1038/ncb1783 18794846
57. SE Ong B Blagoev I Kratchmarova DB Kristensen H Steen A Pandey M Mann 2002 Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics Mol Cell Proteomics 1 376 386 1:CAS:528:DC%2BD38XlslWhsrk%3D 10.1074/mcp.M200025-MCP200 12118079
58. Y Pang DL Hunton P Bounelis RB Marchase 2002 Hyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytes Diabetes 51 3461 3467 1:CAS:528:DC%2BD38Xptl2nurg%3D 10.2337/diabetes.51.12.3461 12453900 (Pubitemid 35403450)
59. JR Phillips T Dalmay D Bartels 2007 The role of small RNAs in abiotic stress FEBS Lett 581 3592 3597 1:CAS:528:DC%2BD2sXotlais70%3D 10.1016/j.febslet.2007.04.007 17451688 (Pubitemid 47081000)
60. XP Ren J Wu X Wang MA Sartor J Qian K Jones P Nicolaou TJ Pritchard GC Fan 2009 MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20 Circulation 119 2357 2366 1:CAS:528:DC%2BD1MXltV2js74%3D 10.1161/CIRCULATIONAHA.108.814145 19380620
61. JL Reyes C Arenas-Huertero R Sunkar 2010 Cloning of stress-responsive microRNAs and other small RNAs from plants Methods Mol Biol 639 239 251 1:CAS:528:DC%2BC3cXosFGgurg%3D 10.1007/978-1-60761-702-0-14 20387050
62. S Sakamoto K Aoki T Higuchi H Todaka K Morisawa N Tamaki E Hatano A Fukushima T Taniguchi Y Agata 2009 The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway Mol Cell Biol 29 3754 3769 1:CAS:528:DC%2BD1MXotlCqurY%3D 10.1128/MCB.01836-08 19398578
63. YB Schwartz V Pirrotta 2009 A little bit of sugar makes polycomb better J Mol Cell Biol 1 11 12 1:CAS:528:DC%2BC3cXlsVSisLc%3D 10.1093/jmcb/mjp008 19671629
64. A Scoumanne X Chen 2008 Protein methylation: a new mechanism of p53 tumor suppressor regulation Histol Histopathol 23 1143 1149 1:CAS:528: DC%2BD1cXptlKnsLs%3D 18581285
65. L Shi D Qiu G Zhao B Corthesy S Lees-Miller WH Reeves PN Kao 2007 Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells Nucleic Acids Res 35 2302 2310 1:CAS:528:DC%2BD2sXmsVWgt7k%3D 10.1093/nar/gkm117 17389650 (Pubitemid 47078747)
66. DA Sinclair M Syrzycka MS Macauley T Rastgardani I Komljenovic DJ Vocadlo HW Brock BM Honda 2009 Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Proc Natl Acad Sci USA 106 13427 13432 1:CAS:528:DC%2BD1MXhtVOitr3E 10.1073/pnas.0904638106 19666537
67. KD Singleton PE Wischmeyer 2008 Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1 JPEN J Parenter Enteral Nutr 32 371 376 1:CAS:528:DC%2BD1cXptFSltLw%3D 10.1177/0148607108320661 18596307 (Pubitemid 351875930)
68. KC Sohn KY Lee JE Park SI Do 2004 OGT functions as a catalytic chaperone under heat stress response: a unique defense role of OGT in hyperthermia Biochem Biophys Res Commun 322 1045 1051 1:CAS:528:DC%2BD2cXntFeqtL8%3D 10.1016/j.bbrc.2004.08.023 15336570 (Pubitemid 39164459)
69. Sunkar R (2010) MicroRNAs with macro effects on plant stress responses. Semin Cell Dev Biol
70. MK Tallent N Varghis Y Skorobogatko L Hernandez-Cuebas K Whelan DJ Vocadlo K Vosseller 2009 In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation J Biol Chem 284 174 181 1:CAS:528:DC%2BD1cXhsFCjtL%2FP 10.1074/jbc.M807431200 19004831
71. J Tang PN Kao HR Herschman 2000 Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3 J Biol Chem 275 19866 19876 1:CAS:528:DC%2BD3cXkslahtbw%3D 10.1074/jbc.M000023200 10749851 (Pubitemid 30441590)
72. Y Tang J Zheng Y Sun Z Wu Z Liu G Huang 2009 MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2 Int Heart J 50 377 387 1:CAS:528:DC%2BD1MXnvVajtL8%3D 10.1536/ihj.50.377 19506341
73. CF Teo S Ingale MA Wolfert GA Elsayed LG Not JC Chatham L Wells GJ Boons 2010 Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc Nat Chem Biol 6 338 343 1:CAS:528:DC%2BC3cXjs1egsro%3D 10.1038/nchembio.338 20305658
74. NS Ting PN Kao DW Chan LG Lintott SP Lees-Miller 1998 DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 J Biol Chem 273 2136 2145 1:CAS:528:DyaK1cXnsVKnsQ%3D%3D 10.1074/jbc.273.4.2136 9442054 (Pubitemid 28069263)
75. E van Rooij LB Sutherland X Qi JA Richardson J Hill EN Olson 2007 Control of stress-dependent cardiac growth and gene expression by a microRNA Science 316 575 579 10.1126/science.1139089 17379774 (Pubitemid 46683138)
76. F Verissimo E Silva JD Morris R Pepperkok P Jordan 2006 Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway Oncogene 25 4172 4182 1:CAS:528:DC%2BD28XmvFais7Y%3D 10.1038/sj.onc.1209449 16501604 (Pubitemid 44079451)
77. AC Vitari M Deak NA Morrice DR Alessi 2005 The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases Biochem J 391 17 24 1:CAS:528: DC%2BD2MXhtVehsL3M 10.1042/BJ20051180 16083423 (Pubitemid 41445471)
78. Z Wang A Pandey GW Hart 2007 Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation Mol Cell Proteomics 6 1365 1379 1:CAS:528:DC%2BD2sXps1aktro%3D 10.1074/mcp.M600453-MCP200 17507370 (Pubitemid 47365435)
79. Z Wang M Gucek GW Hart 2008 Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc Proc Natl Acad Sci USA 105 13793 13798 1:CAS:528: DC%2BD1cXhtFKiurvP 10.1073/pnas.0806216105 18779572
80. Z Wang ND Udeshi M O'Malley J Shabanowitz DF Hunt GW Hart 2010 Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry Mol Cell Proteomics 9 153 160 1:CAS:528:DC%2BC3cXjtFWhs7s%3D 10.1074/mcp.M900268-MCP200 19692427
81. Wang Z, Udeshi ND, Slawson C, Compton PD, Sakabe K, Cheung WD, Shabanowitz J, Hunt DF, Hart GW (2010b) Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 3, ra2
82. FH Wilson S Disse-Nicodeme KA Choate K Ishikawa C Nelson-Williams I Desitter M Gunel DV Milford GW Lipkin JM Achard, et al. 2001 Human hypertension caused by mutations in WNK kinases Science 293 1107 1112 1:CAS:528: DC%2BD3MXmtVWrsrw%3D 10.1126/science.1062844 11498583 (Pubitemid 32758085)
83. J Wysocka CD Allis S Coonrod 2006 Histone arginine methylation and its dynamic regulation Front Biosci 11 344 355 1:CAS:528:DC%2BD2MXhtlSrur3O 10.2741/1802 16146736 (Pubitemid 43253497)
84. P Xu SY Vernooy M Guo BA Hay 2003 The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism Curr Biol 13 790 795 1:CAS:528:DC%2BD3sXjsVGlurw%3D 10.1016/S0960-9822(03)00250-1 12725740 (Pubitemid 36531030)
85. BE Xu S Stippec L Lenertz BH Lee W Zhang YK Lee MH Cobb 2004 WNK1 activates ERK5 by an MEKK2/3-dependent mechanism J Biol Chem 279 7826 7831 1:CAS:528:DC%2BD2cXhsFejtrs%3D 10.1074/jbc.M313465200 14681216 (Pubitemid 38294668)
86. BE Xu BH Lee X Min L Lenertz CJ Heise S Stippec EJ Goldsmith MH Cobb 2005 WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension Cell Res 15 6 10 10.1038/sj.cr.7290256 15686619 (Pubitemid 41653957)
87. CF Xu CH Yu YM Li 2009 Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice OMICS 13 513 520 1:CAS:528:DC%2BC3cXnsF2isg%3D%3D 10.1089/omi.2009.0035 19780683
88. S Yang LY Zou P Bounelis I Chaudry JC Chatham RB Marchase 2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhage Shock 25 600 607 1:CAS:528:DC%2BD28XlvVenu7c%3D 10.1097/01.shk.0000209563.07693.db 16721268 (Pubitemid 44297021)
89. WM Yeo VT Chow 2007 The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat Microb Pathog 42 129 137 1:CAS:528:DC%2BD2sXkt1aktr4%3D 10.1016/j.micpath.2006.12.002 17276651 (Pubitemid 46551639)
90. C Yin X Wang RC Kukreja 2008 Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice FEBS Lett 582 4137 4142 1:CAS:528:DC%2BD1cXhsVOis7zK 10.1016/j.febslet.2008.11.014 19041309
91. C Yin FN Salloum RC Kukreja 2009 A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70 Circ Res 104 572 575 1:CAS:528:DC%2BD1MXisFelu7w%3D 10.1161/CIRCRESAHA.108.193250 19213952
92. NE Zachara GW Hart 2004 O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress Biochim Biophys Acta 1673 13 28 1:CAS:528: DC%2BD2cXltl2htLc%3D 15238246 (Pubitemid 38844791)
93. Zachara NE, Hart GW (2004b) O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular functions in response to nutrition and stress. Biochim Biophys Acta Gen Subj (in press)
94. NE Zachara GW Hart 2006 Cell signaling, the essential role of O-GlcNAc! Biochim Biophys Acta 1761 599 617 1:CAS:528:DC%2BD28Xmt1yksL4%3D 16781888 (Pubitemid 43928866)
95. NE Zachara N O'Donnell WD Cheung JJ Mercer JD Marth GW Hart 2004 Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells J Biol Chem 279 30133 30142 1:CAS:528:DC%2BD2cXlsFKit7c%3D 10.1074/jbc.M403773200 15138254 (Pubitemid 38937936)
96. A Zagorska E Pozo-Guisado J Boudeau AC Vitari FH Rafiqi J Thastrup M Deak DG Campbell NA Morrice AR Prescott, et al. 2007 Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress J Cell Biol 176 89 100 1:CAS:528:DC%2BD2sXktVOmtw%3D%3D 10.1083/jcb.200605093 17190791 (Pubitemid 46041683)
97. L Zou S Yang S Hu IH Chaudry RB Marchase JC Chatham 2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels Shock 27 402 408 1:CAS:528: DC%2BD2sXksVCmsbs%3D 10.1097/01.shk.0000245031.31859.29 17414423 (Pubitemid 46594972)