Impact of age on morbidity and outcome of concurrent radiochemotherapy in high-risk FIGO stage I to IVA carcinoma of the uterine cervix following laparoscopic surgery

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 3, 2011, Pages 481-488

  Laurentius, Thea ^a   Altendorf Hofmann, Annelore ^a   Camara, Oumar ^a   Runnebaum, Ingo B ^a   Wendt, Thomas G ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Carcinoma of uterine cervix; Cervical cancer; Chemoradiation; Elderly; Laparoscopic surgery; Morbidity; Non elderly; Radiochemotherapy

Indexed keywords

CISPLATIN; FLUOROURACIL; NAVELBINE;

ADULT; AGE; AGED; ANEMIA; ARTICLE; BRACHYTHERAPY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CONSTIPATION; CONTINUOUS INFUSION; DIARRHEA; DISEASE FREE SURVIVAL; DIZZINESS; ENTERITIS; ERYTHEMA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FEVER; FOLLOW UP; HIGH RISK POPULATION; HUMAN; HYPERPIGMENTATION; HYPOCALCEMIA; LAPAROSCOPIC SURGERY; LEUKOPENIA; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MORBIDITY; MULTIPLE CYCLE TREATMENT; NAUSEA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PRURITUS; RADICAL HYSTERECTOMY; SEIZURE; SMELLING DISORDER; TASTE DISORDER; THROMBOCYTOPENIA; UTERINE CERVIX CARCINOMA; VOMITING;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYSTERECTOMY; LYMPH NODE EXCISION; MIDDLE AGED; MORBIDITY; NEOPLASM STAGING; RADIOTHERAPY DOSAGE; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 79954430880     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0903-y     Document Type: Article

References (28)

1. Ahamad A, D'Souza W, Salehpour M, Iyer R, Tucker SL, Jhingran A, Eifel PJ (2005) Intensity-modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normal-tissue-sparing effect to margin size. Int J Radiat Oncol Biol Phys 62:1117-1124 (Pubitemid 40884426)
2. Altgassen C, Possover M, Krause N, Plaul K, Michels W, Schneider A (2000) Establishing a new technique of laparoscopic pelvic and para-aortic lymphadenectomy. Obstet Gynecol 95:348-352 (Pubitemid 30100497)
3. Anonymus (2008) Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a ystematic review and metaanalysis of individual patient data from 18 randomized trials. J Clin Oncol 26:5802-5812
4. Brun JL, Stoven-Camou D, Trouette R, Lopez M, Chene G, Hocké C (2003) Survival and prognosis of women with invasive cervical cancer according to age. Gynecol Oncol 91:395-401 (Pubitemid 37351027)
5. Croker AL, Eggleston KS, Du XL, Ramondetta L (2009) Ethnic disparities in cervical cancer survival among medicare eligible women in a multiethnic population. Int J Gynecol Cancer 19:13-20
6. Dimopoulos JCA, Schirl G, Baldinger A, Helbich TH, Pötter R (2009) MRI assessment of cervical cancer for adaptive radiotherapy. Strahlenther Onkol 185:282-287
7. Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J, Rotman M, Gershenson D, Mutch DG (2004) Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol 22:872-880. doi: 10.1200/JCO.2004.07.197 (Pubitemid 41103599)
8. Füller J, Guderian D, Köhler C, Schneider A, Wendt TG (2008) Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer. Strahlenther Onkol 184:206-211 (Pubitemid 351508127)
9. Goodheart M, Jacobson G, Smith BJ, Zhou L (2008) Chemoradiation for invasive cervical cancer in elderly patients: outcomes and morbidity. Int J Gynecol Cancer 18:95-103
10. Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M, Williams CJ (2001) Systematic review and meta-analysis of randomised trials of concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: better survival and reduced distant recurrence rate. Lancet 358:781-786 (Pubitemid 32868726)
11. Huscher A, Bignardi M, Magri E, Vitali E, Pasinetti N, Costa L, Frata P, Magrini SM (2009) Determinants of small bowel toxicity in postoperative pelvic irradiation for gynaecological malignancies. Anticancer Res 11:4821-4826
12. Kirwan JM, Symonds P, Green JA, Tierney J, Collingwood M, Williams CJ (2003) A systematic review of acute and late toxicity of concomitant chemo-radiation for cervical cancer [review]. Radiother Oncol 68:217-226 (Pubitemid 38373421)
13. Köhler C, Klemm P, Schau A, Possover M, Krause N, Tozzi R, Schneider A (2004) Introduction of and/or paraaortic transperitoneal lymphadenectomies. Gynecol Oncol 95:52-61
14. Kunos C, Tian C, Waggoner S, Rose PG, Lanciano R (2009) Retrospective analysis of concomitant cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a gynecologic oncology group study. Int J Gynecol Cancer 19:1258-1263
15. Lindegaard JC, Thranov IR, Engelholm SA (2000) Radiotherapy in the management of cervical cancer in elderly patients. Radiother Oncol 56:9-15 (Pubitemid 30408380)
16. McNeil C (1999) New standard of care for cervical cancer sets stage for next questions. J Natl Cancer Inst 91:500-513
17. Metindir J, Bilir G (2007) Prognostic factors affecting disease-free survival in early-stage cervical cancer patients undergoing radical hysterectomy and pelvic-araaortic lymphadenectomy. Eur J Gynaecol Oncol 28:28-32 (Pubitemid 46408227)
18. Minagawa Y, Kigawa J, Itamochi H, Terakawa N (1997) The outcome of radiation therapy in elderly patients with advanced cervical cancer. Int J Gynaecol Obstet 58:305-309 (Pubitemid 27361873)
19. Mitchell PA, Waggoner S, Rotmensch J, Mundt AJ (1998) Cervical cancer in the elderly treated with radiation therapy. Gynecol Oncol 71:291-298 (Pubitemid 28550815)
20. Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, Rotman M, Gershenson DM, Mutch DG (1999) Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340:1137-1143 (Pubitemid 29177872)
21. NIH (1998) Common terminology criteria for adverse events v 2.0. National Institutes of Health, Bethesda
22. Peters WA III, Liu PY, Barrett RJ II, Stock RJ, Monk BJ, Berek JS, Souhami L, Grigsby P, Gordon W Jr, Alberts DS (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18:1606-1613 (Pubitemid 30220538)
23. Pignon T, Horiot JC, Bolla M, van Poppel H, Bartelink H, Roelofsen F, Pene F, Garard A, Einhorn N, Nguyen TD, Vanglabbeke M, Scalliet P (1997) Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol 42:107-120 (Pubitemid 27132740)
24. Rose P, Bundy B, Watkins E, Thigpen JT, Deppe G, Maiman M, Clarke-Pearson DL, Insalaco S (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144-1153 (Pubitemid 29177873)
25. Sakurai H, Mitsuhashi N, Takahashi M, Yamakawa M, Akimoto T, Hayakawa K, Niibe H (2000) Radiation therapy for elderly patient with squamous cell carcinoma of the uterine cervix. Gynecol Oncol 77:116-120 (Pubitemid 30217314)
26. Stabenow R, Streller B, Wilsdorf-Köhler H, Eisinger B (2009) Gemeinsames Krebsregister. Krebsinzidenz und Krebsmortalität 2005/2006. http://www.berlin. de/gkr/publikationen/jahresberichte/
27. Vandecasteele K, De Neve W, De Gersem W, Delrue L, Paelinck L, Makar A, Fonteyne V, De Wagter C, Villeirs G, De Meerleeer G (2009) Intensity moduated arc therapy with simultaneous integrated boost in the treatemtn of primary irresectable cervical cancer. Treatment planning, quality control and clinical implementation. Strahlenther Onkol 185:799-807
28. Wright JD, Gibb RK, Geevarghese S, Powell MA, Herzog TJ, Mutch DG, Grigsby PW, Gao F, Trinkaus KM, Rader JS (2005) Cervical carcinoma in the elderly. An analysis of patterns of care and outcome. Cancer 103:85-91 (Pubitemid 39665460)