Disseminated Rhizomucor pusillus causing early multiorgan failure during hematopoietic stem cell transplantation for severe aplastic anemia

Journal of Pediatric Hematology/Oncology

Volumn 33, Issue 3, 2011, Pages 235-237

  Rawlinson, Neil J ^a   Fung, Bonita ^a   Gross, Thomas G ^a   Termuhlen, Amanda M ^a   Skeens, Micah ^a   Garee, Amy ^a   Soni, Sandeep ^a   Pietryga, Daniel ^a   Bajwa, Rajinder P S ^a  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

aplastic anemia; fungal infection; hematopoietic stem cell transplantation; multiorgan failure

Indexed keywords

ACICLOVIR; AMPHOTERICIN; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; FLUCONAZOLE; LEVOFLOXACIN; LINEZOLID; METHOTREXATE; METHYLPREDNISOLONE; MICAFUNGIN; PIPERACILLIN PLUS TAZOBACTAM; POSACONAZOLE; TACROLIMUS; THYMOCYTE ANTIBODY; VANCOMYCIN; VORICONAZOLE;

ABDOMINAL DISTENSION; ABDOMINAL DRAINAGE; APLASTIC ANEMIA; ARTHRALGIA; ARTICLE; AUTOPSY; BLOOD TRANSFUSION; BONE MARROW BIOPSY; BORDERLINE HYPERTENSION; CASE REPORT; CHILD; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; EPISTAXIS; FEBRILE NEUTROPENIA; FEMALE; FLUID RETENTION; FUNGAL DETECTION; GRAFT VERSUS HOST REACTION; HEART FAILURE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBIN BLOOD LEVEL; HEPATOMEGALY; HUMAN; HUMAN TISSUE; HYPOTENSION; HYPOXIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DYSFUNCTION; KIDNEY FAILURE; LEUKOCYTE COUNT; LIMB PERFUSION; LIVER FAILURE; MUCOSA INFLAMMATION; MULTIPLE ORGAN FAILURE; MYCOSIS; NEUTROPHIL COUNT; PHYSICAL EXAMINATION; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RASH; RESPIRATORY TRACT INTUBATION; RHIZOMUCOR; RHIZOMUCOR PUSILLUS; SCHOOL CHILD; SERUM SICKNESS; SKIN BLEEDING; SYSTEMIC MYCOSIS; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; TREATMENT OUTCOME;

AMPHOTERICIN B; ANEMIA, APLASTIC; CHILD; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MUCORMYCOSIS; MULTIPLE ORGAN FAILURE; PYRIMIDINES; RHIZOMUCOR; TRIAZOLES;

EID: 79954426206     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3182050a4f     Document Type: Article

References (12)

1. Locasciulli A, Oneto R, Bacigalupo A, et al. Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT). Haematologica. 2007;92:11-18. (Pubitemid 46232653)
2. Bacigalupo A. Treatment strategies for patients with severe aplastic anemia. Bone Marrow Transplant. 2008;42(suppl 1):S42-S44.
3. Dvorak CC, Steinbach WJ, Brown JM, et al. Risks and outcomes of invasive fungal infections in pediatric patients undergoing allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2005;36:621-629. (Pubitemid 43115019)
4. Cuenca-Estrella M, Bernal-Martinez L, Isla G, et al. Incidence of zygomycosis in transplant recipients. Clin Microbiol Infect. 2009;15(suppl 5):37-40.
5. Bhatti Z, Shaukat A, Almyroudis NG, et al. Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients. Mycopathologia. 2006;162:1-15. (Pubitemid 44025055)
6. Ambrosioni J, Bouchuiguir-Wafa K, Garbino J. Emerging invasive zygomycosis in a tertiary care center: epidemiology and associated risk factors. Int J Infect Dis. 2010;14(suppl 3):e100-e103.
7. Ullmann AJ, Lipton JH, Vesole DH, et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med. 2007;356:335-347. (Pubitemid 46148776)
8. Cornely OA, Maertens J, Winston DJ, et al. Posaconazole versus fluconazole or itraconazole prophylaxis in patients with neutropenia. N Engl J Med. 2007;356:348-359. (Pubitemid 46148777)
9. Wilson DT, Drew RH, Perfect JR. Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update. Mycopathologia. 2009;168:313-327.
10. Kontoyiannis DP, Marr KA, Park BJ, et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis. 2010;50:1091-1100.
11. Kontoyiannis DP, Chamilos G, Lewis RE, et al. Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation. Cancer. 2007;110:1303-1306. (Pubitemid 47435602)
12. Ibrahim AS, Spellberg B, Edwards J Jr. Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis. 2008;21:620-625.