Assessment of the influence factors on nasal spray droplet velocity using Phase-Doppler Anemometry (PDA)

AAPS PharmSciTech

Volumn 12, Issue 1, 2011, Pages 337-343

  Liu, Xiaofei ^a   Doub, William H ^a   Guo, Changning ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

design of experiments; droplet velocity; nasal spray; phase Doppler anemometry

Indexed keywords

BECLOMETASONE DIPROPIONATE; CROMOGLYCATE DISODIUM; DESMOPRESSIN; FLUNISOLIDE; FLUTICASONE PROPIONATE; MOMETASONE FUROATE;

ANEMOMETRY; ARTICLE; BOX BEHNKEN DESIGN OF EXPERIMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; METHODOLOGY; PHARMACEUTICAL ENGINEERING; PHASE DOPPLER ANEMOMETRY; PRIORITY JOURNAL;

ADMINISTRATION, INTRANASAL; AEROSOLS; CELLULOSE; DRUG DELIVERY SYSTEMS; EXCIPIENTS; GELS; HUMANS; NASAL SPRAYS; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POLYSORBATES; RESEARCH DESIGN; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 79954425430     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9594-1     Document Type: Article

References (12)

1. U.S. Food and Drug Administration. Draft guidance for industry: metered dose inhaler (MDI) and dry powder inhaler (DPI) drug products. 1998.
2. U.S. Food and Drug Administration. Guidance for industry: nasal spray and inhalation solution, suspension, and spray drug products-chemistry, manufacturing, and controls documentation. 2002.
3. U.S. Food and Drug Administration. Draft guidance for industry: bioavailability and bioequivalence studies for nasal aerosols and nasal sprays for local action. 2003.
4. Guo C, Doub WH. Development of a novel technology to measure impaction force of nasal sprays and metered dose inhalers using the texture analyser. In: Byron PR, Peart J, Suman JD, Farr SJ, Dalby RN, editors. Respiratory drug delivery. River Grove: Davis Healthcare International Publishing; 2006. p. 621-4.
5. C Guo W Ye JF Kauffman WH Doub 2009 Evaluation of impaction force of nasal sprays and metered-dose inhalers using the texture analyser J Pharm Sci 98 8 2799 2806 19097159 10.1002/jps.21648 1:CAS:528:DC%2BD1MXns1eqt7o%3D
6. X Liu WH Doub C Guo 2010 Evaluation of droplet velocity and size from nasal spray devices using phase Doppler anemometry (PDA) Int J Pharm 388 1-2 82 87 20043981 10.1016/j.ijpharm.2009.12.041 1:CAS:528:DC%2BC3cXit1Sgt7o%3D
7. Albrecht H-E, Damaschke N, Borys M, Tropea C. Laser Doppler and phase Doppler measurement techniques. In: Merzkirch, Wolfgang, Rockwell, Donald, Tropea, Cameron, editors. Experimental fluid mechanics, ed. New York: Springer-Verlag Berlin Heidelberg; 2003. p. 738.
8. P Dayal M Shaik M Singh 2004 Evaluation of different parameters that affect droplet-size distribution from nasal sprays using the Malvern Spraytec J Pharm Sci 93 1725 1742 15176062 10.1002/jps.20090 1:CAS:528:DC%2BD2cXltlKrsrs%3D (Pubitemid 38823701)
9. C Guo WH Doub 2006 The influence of actuation parameters on in vitro testing of nasal spray products J Pharm Sci 95 2029 2040 16865693 10.1002/jps.20678 1:CAS:528:DC%2BD28XpsFehtb0%3D (Pubitemid 44433032)
10. Dayal P, Pillay V, Babu, JR, Singh, M. Box-Behnken experimental design in the development of a nasal drug delivery system of model drug hydroxyurea: characterization of viscosity, in vitro drug release, droplet size, and dynamic surface tension. AAPS PharmSciTech. 2005; 6(4):Article 72.
11. C Guo KJ Stine JF Kauffman WH Doub 2008 Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design Eur J Pharm Sci 35 12 417 426 18832029 10.1016/j.ejps.2008.09.001 1:CAS:528:DC%2BD1cXhtlyiu77K
12. Takeuchi G, Kawaguchi T, Hishida K, Maeda M, Sommerfeld, M. Spatial distributions of droplet size and velocity in air heated spray measured by interferometric laser imaging technique. 12th International Symposium on Applications of Laser Techniques to Fluid Mechanics, ed., Lisbon, Portugal. 2004.