Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design

European Journal of Pharmaceutical Sciences

Volumn 35, Issue 5, 2008, Pages 417-426

  Guo, Changning ^a   Stine, Keith J ^b   Kauffman, John F ^a   Doub, William H ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

Automated actuation; Box Behnken experimental design; Droplet size distribution; In vitro testing; Nasal drug delivery; Plume geometry; Shot weight; Spray pattern; Surface tension; Viscosity

Indexed keywords

CARBOXYMETHYLCELLULOSE; GELLING AGENT; NOSE SPRAY; POLYSORBATE 80; SURFACTANT;

AQUEOUS SOLUTION; ARTICLE; BOX BEHNKEN EXPERIMENTAL DESIGN; DENSITY; DROPLET SIZE DISTRIBUTION; DRUG DELIVERY SYSTEM; EXPERIMENTAL DESIGN; IN VITRO STUDY; INSTRUMENTATION; MATHEMATICAL MODEL; PHYSICAL CHEMISTRY; PLUME GEOMETRY; PRIORITY JOURNAL; SPRAY PATTERN; SURFACE TENSION; VISCOSITY;

ADMINISTRATION, INTRANASAL; AEROSOLS; CARBOXYMETHYLCELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MODELS, STATISTICAL; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POLYSORBATES; REGRESSION ANALYSIS; RESEARCH DESIGN; SOFTWARE; SURFACE TENSION; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 55949123862     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.09.001     Document Type: Article

References (8)

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