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Tarnow-Mordi WO, Wilkinson D, Trivedi A, Brok J. Probiotics reduce all-cause mortality and necrotizing enterocolitis: it is time to change practice. Pediatrics 2010; 125:1068-1070. A recent editorial encouraging use of probiotics for preterm infants, and providing parents with current evidence for use.
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Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns
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This study, conducted in India, used prophylactic probiotics for VLBW infants and found a reduction in NEC, death, and culture proven sepsis, as well as reduction in time to full enteral feeds and hospital stay, which was not reported in previous studies
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Samanta M, Sarkar M,Ghosh P, et al. Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr 2009; 55:128-131. This study, conducted in India, used prophylactic probiotics for VLBW infants and found a reduction in NEC, death, and culture proven sepsis, as well as reduction in time to full enteral feeds and hospital stay, which was not reported in previous studies.
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This meta-analysis evaluated 11 trials using probiotics for preterm infants and found significant reductions in NEC and death. The authors encourage routine use of probiotics in this population
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Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010; 125:921-930. This meta-analysis evaluated 11 trials using probiotics for preterm infants and found significant reductions in NEC and death. The authors encourage routine use of probiotics in this population.
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