Physicochemical characterization of NPC 1161C, a novel antimalarial 8-aminoquinoline, in solution and solid state

AAPS PharmSciTech

Volumn 12, Issue 1, 2011, Pages 177-191

  Dutta, Asish Kumar ^a,c   Stodghill, Steven P ^a,b,d   Wyandt, Christy M ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c NOTRE DAME OF MARYLAND UNIVERSITY   (United States)

^d BELMONT UNIVERSITY   (United States)

Author keywords

log P; NPC 1161C; pKa; preformulation; solubility; thermal analysis

Indexed keywords

8 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; NPC 1161C; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STABILITY; PH; PHYSICAL CHEMISTRY; PREFORMULATION; PRIORITY JOURNAL; SOLID STATE; TEMPERATURE; THERMAL ANALYSIS; THERMOGRAVIMETRY;

AMINOQUINOLINES; ANTIMALARIALS; DOSAGE FORMS; DRUG STABILITY; HOT TEMPERATURE; HUMANS; HYDROGEN-ION CONCENTRATION; SOLUBILITY; SOLUTIONS; SUCCINATES;

EID: 79954419864     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9578-6     Document Type: Article

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