Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for NPC 1161C, a novel 8-aminoquinoline anti-malarial drug

Journal of Chromatography A

Volumn 1110, Issue 1-2, 2006, Pages 35-45

  Dutta, Asish K ^a   Avery, Bonnie A ^a,b   Wyandt, Christy M ^a,b  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Forced degradation; HPLC; Mass spectrometry; Method development; NPC 1161C; Reversed phase; Stability indicating; Validation

Indexed keywords

BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; MASS SPECTROMETRY; OPTICAL RESOLVING POWER; TISSUE;

FORCED DEGRADATION; METHOD DEVELOPMENT; NPC 1161C; REVERSED-PHASE; STABILITY INDICATING; VALIDATION;

DRUG PRODUCTS;

8 [(4 AMINO 1 METHYLBUTYL)AMINO 5 (3,4 DICHLOROPHENOXY) 6 METHOXY 4 METHYLQUINOLINE SUCCINATE; 8 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; NPC 1161C; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG OXIDATION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; PRIORITY JOURNAL; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRESS; VALIDATION STUDY;

AMINOQUINOLINES; ANTIMALARIALS; BIODEGRADATION, ENVIRONMENTAL; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUCCINATES;

EID: 33644853814     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.01.040     Document Type: Article

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