Effect of GABA-ergic mechanisms on synaptosomal NO synthesis and the nitrergic component of NANC relaxation in rat ileum

Neurogastroenterology and Motility

Volumn 23, Issue 5, 2011, Pages

  Kurjak, M ^a   Fichna, J ^b   Harbarth, J ^c   Sennefelder, A ^a   Allescher, H D ^d   Schusdziarra, V ^e   Storr, M ^b   Otto, B ^f  

^a Endooffice Abdomen   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

^c Klinikum Harlaching   (Germany)

^d Klinikum Garmisch Partenkirchen   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Enteric nerve terminals; GABA A receptor; GABA C(GABA A ) receptor; Nitric oxide synthase; Non adrenergic non cholinergic relaxation

Indexed keywords

(1,2,5,6 TETRAHYDROPYRIDIN 4 YL) METHYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID C RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID C RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOCROTONIC ACID; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; BACLOFEN; BICUCULLINE; MUSCIMOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; GABAERGIC SYSTEM; GASTROINTESTINAL TRACT FUNCTION; ILEUM; MALE; NERVE ENDING; NITRERGIC NERVE; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; ILEUM; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GABA; SYNAPSES; SYNAPTOSOMES;

EID: 79953895455     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2011.01688.x     Document Type: Article

References (46)

1. Jessen KR, Mirsky R, Dennison ME, Burnstock G. GABA may be a neurotransmitter in the vertebrate peripheral nervous system. Nature 1979; 281: 71-4.
2. Krantis A, Harding RK. GABA-related actions in isolated in vitro preparations of the rat small intestine. Eur J Pharmacol 1987; 141: 291-8.
3. Jessen KR, Hills JM, Saffrey MJ. Immunohistochemical demonstration of GABAergic neurons in the enteric nervous system. Neuroscience 1986; 6: 1628-34.
4. Hills JM, Jessen KR, Mirsky R. An immunohistochemical study of the distribution of enteric GABA-containing neurons in the rat and guinea-pig intestine. Neuroscience 1987; 22: 301-12.
5. Saito N, Tanaka C. Immunohistochemical demonstration of GABA containing neurons in the guinea-pig ileum using purified GABA antiserum. Brain Res Bull 1986; 376: 78-84.
6. Saffrey MJ, Marcus N, Jessen KR, Burnstock G. Distribution of neurons with high-affinity uptake sites for GABA in the myenteric plexus of the guinea-pig, rat and chicken. Cell Tissue Res 1983; 234: 231-5.
7. Williamson S, Pompolo S, Furness JB. GABA and nitric oxide synthase immunoreactivities are colocalized in a subset of inhibitory motor neurons of the guinea-pig small intestine. Cell Tissue Res 1996; 284: 29-37.
8. Olsen RW, Sieghart W. Int. Union of Pharmacol. LXX. Subtypes of gamma-aminobutyric acid (A) receptors: classification on the basis of subunit composition, pharmacology and function. Update. Pharmacology Rev 2008; 60: 243-60.
9. Amin J, Weiss DS. Homomeric p1 GABA channels: activation properties and domains. Receptor Channels 1994; 2: 227-36.
10. Napoleone P, Cavallotti C, de Vincentis G, Amenta F. Autoradiographic localization of the GABA(A)-receptor agonist 3-(H)-Muscimol in the rat intestinal musculature. Pharmacology 1991; 42: 103-10.
11. Krantis A, Shabnavard L, Nichols K, de Blas AL, Staines W. Localization of GABA(A) receptor immunoreactivity in NO synthase positive myenteric neurones. J Auton Nerv Syst 1995; 53: 157-65.
12. Fletcher EL, Clark MJ, Senior P, Furness JB. Gene expression and localization of GABA(C) receptors in neurons of the rat gastrointestinal tract. Neuroscience 2001; 107: 181-9.
13. Nakajima K, Tooyama I, Kuriyama K, Kimura H. Immunohistochemical demonstration of GABA(B) receptors in the rat gastrointestinal tract. Neurochem Res 1996; 21: 211-5.
14. Jansen A, Hoepfner M, Herzig KH, Riecken EO, Scherubl H. GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut. Pflugers Arch 2000; 441: 294-300.
15. Fletcher EL, Clark MJ, Furness JB. Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus. Cell Tissue Res 2002; 308: 339-46.
16. Inouye A, Fukuya M, Tsuchiya K, Tsujiyoka T. Studies on the effects of aminobutyric acid on the isolated guinea-pig ileum. Jpn J Physiol 1960; 10: 167-82.
17. Ong J, Kerr DIB. GABA(A)- and GABA(B)-receptor-mediated modification of intestinal motility. Eur J Pharmacol 1983; 86: 9-17.
18. Zizzo MG, Mulè F, Serio R. Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors. Neuropharmacology 2007; 52: 1685-90.
19. Kleinrok A, Kilbinger H. Gamma-aminobutyric acid and cholinergic transmission in the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 1983; 322: 216-20.
20. Hebeiss K, Kilbinger H. Cholinergic and GABAergic regulation of nitric oxide synthesis in the guinea-pig ileum. Am J Physiol (Gastrointest Liver Physiol) 1999; 276: G862-6.
21. Takeda T, Taniyama K, Baba S, Tanaka C. Putative mechanisms involved in excitatory and inhibitory effects of somatostatin on intestinal motility. Am J Physiol (Gastrointest Liver Physiol) 1989; 257: G532-8.
22. Krantis A, Mattar K, Glasgow I. Rat gastroduodenal motility in vivo: interaction of GABA and VIP in control of spontaneous relaxations. Am J Physiol (Gastrointest Liver Physiol) 1998; 275: G897-903.
23. Boeckxstaens GE, Pelckmans PA, Rampart M et al. GABA(A) receptor-mediated stimulation of non-adrenergic non-cholinergic neurones in the dog ileocolonic junction. Br J Pharmacol 1990; 101: 460-4.
24. Yau W, Verdun PR. Release of gamma-aminobutyric acid from guinea-pig myenteric plexus synaptosomes. Brain Res Bull 1983; 278: 271-3.
25. Kurjak M, Allescher HD, Schusdziarra V, Classen M. Release of bombesin-like immunoreactivity from synaptosomal membranes isolated from the rat ileum. Eur J Pharmacol 1994; 257: 169-79.
26. Huber A, Saur D, Kurjak M, Schusdziarra V, Allescher HD. Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine. Am J Physiol 1998; 275: G1146-56.
27. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976; 72: 248-54.
28. Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 1989; 86: 9030-3.
29. Storr M, Koppitz P, Sibaev A et al. Melatonin reduces non-adrenergic, non-cholinergic relaxant neurotransmission by inhibition of nitric oxide synthase activity in the gastrointestinal tract of rodents in vitro. J Pineal Res 2002; 33: 101-8.
30. Benko R, Undi S, Wolf M et al. P2 purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.. Naunyn Schmiedebergs Arch Pharmacol 2006; 373: 319-24.
31. Okishio Y, Niioka S, Yamaji M et al. Mediators of nonadrenergic, noncholinergic relaxation in Sprague Dawley rat intestine: comparison with the mediators of other strains. J Vet Med Sci 2000; 62: 821-8.
32. Niioka S, Takeuchi T, Kishi M et al. nonadrenergic, noncholinergic relaxation in longitudinal muscle of rat jejunum. Jpn J Pharmacol 1997; 73: 155-61.
33. Matsuda NM, Miller SM. Non-adrenergic non-cholinergic inhibition of gastrointestinal smooth muscle and its intracellular mechanism(s). Fundam Clin Pharmacol 2010; 24: 261-8.
34. Gil V, Gallego D, Grasa L, Martin MT, Jimenez M. Purinergic and nitrergic-neuromuscular transmission mediates spontaneous neuronal activity in the rat colon. Am J Physiol 2010; 299: G158-69.
35. Van Crombruggen K, Lefebvre RA. Nitrergic-purinergic interactions in rat distal colon motility. Neurogastroenterol Motil 2004; 16: 81-98.
36. Maggi CA, Manzini S, Meli A. GABA A receptor mediate neurogenic inhibition of motility in the small intestine of urethane-anaesthetized rats. Gen Pharmacol 1986; 2: 167-71.
37. Page AJ, Blackshaw LA. GABA(B) receptors inhibit mechanosensitivity of primary afferent endings. J Neurosci 1999; 19: 8597-602.
38. McDermott CM, Abrahams TP, Partosoedarso E et al. Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats. Gastroenterology 2001; 120: 1749-62.
39. Sengupta JN, Medda BK, Shaker R. Effect of GABA(B) receptor agonist on distension-sensitive pelvic nerve afferent fibers innervating rat colon. Am J Physiol (Gastrointest Liver Physiol) 2002; 283: G1343-51.
40. Frigo GM, Galli A, Lecchini S, Marcoli MA. A facilitory effect of bicuculline on the enteric neurones in the guinea-pig isolated colon. Br J Pharmacol 1987; 90: 31-41.
41. Bayer S, Jellali A, Crenner F, Aunis D, Angel F. Functional evidence for a role of GABA receptors in modulation nerve activities of circular smooth muscle from rat colon in vitro. Life Sci 2003; 72: 1481-93.
42. Tonini M, Crema A, Frigo GM, Rizzi CAML, Candura SM, Onori L. An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit. Br J Pharmacol 1989; 98: 1109-18.
43. Madsen KK, White HS, Schousboe A. Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs. Pharmacol Ther 2010; 125: 394-401.
44. Poulter MO, Singhal R, Brown LA, Krantis A. GABA(A) receptor subunit messenger RNA expression in the enteric nervous system of the rat: implications for functional diversity of enteric GABA(A) receptors. Neuroscience 1999; 93: 1159-65.
45. Gingrich KJ, Roberts WA, Kass RS. Dependence of the GABA A receptor gating kinetics on the α-subunit isoform: implications for structure-function relations and synaptic transmission. J Physiol 1995; 2: 529-43.
46. Verdoorn TA. Formation of heteromeric GABA type A receptors containing two different α subunits. Mol Pharmacol 1994; 45: 475-80.