Effects of physical exercise on ADHD-like behavior in male and female adolescent spontaneously hypertensive rats

Developmental Psychobiology

Volumn 53, Issue 4, 2011, Pages 383-390

  Robinson, Andrea M ^a   Hopkins, Michael E ^a   Bucci, David J ^a  

^a Dartmouth College   (United States)

Author keywords

Associative learning; Attention; Attention deficit hyperactivity disorder; Development; Orienting behavior

Indexed keywords

ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; DISEASE MODEL; EXPLORATORY BEHAVIOR; FEMALE; LEARNING; MALE; MOTOR ACTIVITY; ORIENTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ASSOCIATION LEARNING; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; MALE; MOTOR ACTIVITY; ORIENTATION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

ANIMALIA; RATTUS;

EID: 79953880226     PISSN: 00121630     EISSN: 10982302     Source Type: Journal    
DOI: 10.1002/dev.20530     Document Type: Article

References (46)

1. Adams, K. L., Parfeniuk, G. G., & Eikelboom, R. (2009). Chlorpromazine specifically prevents the wheel-induced feeding suppression in rats. Pharmacology Biochemistry and Behavior, 93(4), 470-473.
2. Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005). The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiology of Aging, 26, 511-520.
3. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 3rd edition. Washington, DC: American Psychiatric Association.
4. Biederman, J., Spencers, T., & Wilens, T. (2004). Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. International Journal of Neuropsychopharmacology, 7, 77-97.
5. Binder, E., Droste, S. K., Ohi, F., & Reul, J. M. (2004). Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice. Behavioural Brain Research, 155(2), 197-206.
6. Calfas, K. J., & Taylor, W. C. (1994). Effects of physical activity on psychological variables in adolescents. Pediatric Exercise Science, 6(4), 406-423.
7. Cotman, C. W., & Berchtold, N. C. (2002). Exercise: A behavioral intervention to enhance brain health and plasticity. Trends in Neuroscience, 25(6), 295-301.
8. Davids, E., Zhang, K., Tarazi, F. I., & Baldessarini, R. J. (2003). Animal models of attention-deficit hyperactivity disorder. Brain Research Reviews, 42(1), 1-21.
9. Dixon, D. P., Ackert, A. M., & Eckel, L. A. (2003). Development of, and recovery from, activity-based anorexia in female rats. Physiology and Behavior, 80(2-3), 273-279.
10. Fox, J. H., Hammack, S. E., & Falls, W. A. (2008). Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle. Behavioral Neuroscience, 122(4), 943-948.
11. Gallagher, M., Graham, P. W., & Holland, P. C. (1990). The amygdala central nucleus and appetitive Pavlovian conditioning: Lesions impair one class of conditioned behavior. Journal of Neuroscience, 10, 1906-1911.
12. Grace, L., Hescham, S., Kellaway, L. A., Bugarith, K., & Russell, V. A. (2009). Effect of exercise on learning and memory in a rat model of developmental stress. Metabolic Brain Disease, 24, 643-657.
13. Halperin, J. M., & Healey, D. M. (2010). The influences of environmental enrichment, cognitive enhancement, and physical exercise on brain development: Can we alter the developmental trajectory of ADHD? Neuroscience and Biobehavioral Reviews, 35, 621-634.
14. Hattorii, S., Naoi, M., & Nishino, H. (1994). Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running. Brain Research Bulletin, 35, 41-49.
15. Holland, P. C. (1977). Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response. Journal of Experimental Psychology: Animal Behavior Processes, 3, 77-104.
16. Hopkins, M. E., Sharma, M., Evans, G. C., & Bucci, D. J. (2009). Voluntary physical exercise alters attentional orienting and social behavior in a rat model of attention-deficit/hyperactivity disorder. Behavioral Neuroscience, 123, 599-606.
17. Hopkins, M. E., & Bucci, D. J. (2010). BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory. Neurobiology of Learning and Memory, 94(2), 278-284.
18. Kantak, K. M., Singh, T., Kerstetter, K. A., Dembro, K. A., Mutebi, M. M., Harvey, R. C., et al. (2008). Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder. Behavioral Neuroscience, 29, 496-505.
19. Keene, C. S., & Bucci, D. J. (2007). Automated measure of conditioned orienting behavior in rats. Behavior Research Methods, 39, 303-308.
20. Kim, Y., Kim, H., Shin, M., Chang, H., Jang, M., Shin, M., et al. (2004). Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. Neuroscience Letters, 355, 152-154.
21. Leasure, J. L., & Decker, L. (2009). Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats. Hippocampus, 19(10), 907-912.
22. Linkenhoker, B. A., von der Ohe, C. G., & Knudsen, E. I. (2005). Anatomical traces of juvenile learning in the auditory system of adult barn owls. Nature Neuroscience, 8(1), 93-98.
23. Lubow, R. E., & Moore, A. U. (1959). Latent inhibition: The effect of nonreinforced preexposure to the conditioned stimuli. Journal of Comparative and Physiological Psychology, 52, 415-419.
24. Mueller, D. T., Loft, A., & Eikelboom, R. (1997). Alternate-day wheel access: Effects on feeding, body weight, and running. Physiology and Behavior, 62(4), 905-908.
25. Muchimapura, S., Fulford, A. J., Mason, R., & Marsden, C. A. (2002). Isolation rearing in the rat disrupts the hippocampal response to stress. Neuroscience. 112(3), 697-705.
26. Naylor, A. S., Persson, A. I., Eriksson, P. S., Jonsdottir, I. H., & Thorlin, T. (2005). Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. Journal of Neurophysiology, 93(5), 2406-2414.
27. Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., et al. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America, 104(13), 5638-5643.
28. Rice, D., & Barone, S. Jr., (2000). Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environmental Health Perspectives, 108, 511-533.
29. Russell, V. A. (2002). Hypodopaminergic and hypernoradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder-The spontaneously hypertensive rat. Behavioral Brain Research, 130(1-2), 191-196.
30. Russell, V. A. (2007). Neurobiology of animal models of attention-deficit/hyperactivity disorder. Journal of Neuroscience Methods, 161, 185-198.
31. Sagvolden, T. (2000). Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD). Neuroscience and Biobehavioral Reviews, 24, 31-39.
32. Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005). Rodent models of attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 1239-1247.
33. Solanto, M. V., & Coners, C. K. (1982). A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity. Psychophysiology, 19(6), 658-667.
34. Stensel, D. J., Gorely, T., & Biddle, S. J. H. (2008). Physical (in)activity and youth health outcomes. In: A. L. Smith, & S. J. H. Biddle (Eds.), Youth physical activity and inactivity: Challenges and solutions. Champaign, IL: Human Kinetics.
35. Steptoe, A., & Butler, N. (1996). Sports participation and emotional wellbeing in adolescents. Lancet, 347(9018), 1789-1792.
36. Stranahan, A. M., Khalil, D., & Gould, E. (2006). Social isolation delays the positive effects of running on adult neurogenesis. Nature Neuroscience, 9(4), 526-533.
37. Strong, W. B., Malina, R. M., Blimkie, C. J. R., Daniels, S. R., Dishman, R. K., Gutin, B., et al. (2005). Evidence based physical activity for school-age youth. Journal of Pediatrics, 146, 732-737.
38. Swanson, J. K., Elliot, G. R., Greenhill, L. L., Wigal, T., Arnold, L. E., Conners, C. K., et al. (2007). Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1015-1027.
39. Tantillo, M., Kesick, C. M., Hynd, G. W., & Dishman, R. K. (2002). The effects of exercise on children with attention-deficit hyperactivity disorder. Medicine and Science in Sports and Exercise, 34(2), 203-212.
40. Uysal, N., Tugyan, K., Kayatekin, B. M., Acikgoz, O., Bagriyanik, H. A., Gonenc, S., et al. (2005). The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis, and spatial memory. Neuroscience Letters, 383, 241-245.
41. van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999). Running enhances neurogenesis, learning, and long-term potentiation in mice. Proceedings of the National Academy of Sciences of the United States of America, 96, 13427-13431.
42. Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience, 20, 2580-2590.
43. Volkow, N. D., & Insel, T. R. (2003). What are the long-term effects of methylphenidate treatment? Biological Psychiatry, 54, 1307-1309.
44. Wiberg, G. S., & Grice, H. C. (1963). Long-term isolation stress in rats. Science, 25, 142-507.
45. Winter, B., Breitenstein, C., Mooren, F. C., Voelker, K., Fobker, M., Lechtermann, A., et al. (2007). High impact running improves learning. Neurobiology of Learning and Memory, 87, 597-609.
46. Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., et al. (2006). Beneficial effects of exercise and its molecular mechanisms on depression in rats. Behavioral Brain Research, 168(1), 47-55.