Disseminated fusariosis occurring in two patients despite posaconazole prophylaxis

Journal of Clinical Microbiology

Volumn 49, Issue 4, 2011, Pages 1674-1675

  Bose, Prithviraj ^a,c   Parekh, Hiral D ^b,c   Holter, Jennifer L ^a,c   Greenfield, Ronald A ^b,c,d  

^a Section of Hematology/Oncology   (United States)

^b Department of Internal Medicine ^*  (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; CLADRIBINE; CYTARABINE; FLUCONAZOLE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; IMIPENEM; METRONIDAZOLE; MITOXANTRONE; PIPERACILLIN PLUS TAZOBACTAM; POSACONAZOLE; VANCOMYCIN; VORICONAZOLE;

ABSCESS DRAINAGE; ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANEMIA; ANTIBIOTIC SENSITIVITY; ARTICLE; BLOOD CULTURE; BONE MARROW BIOPSY; BROTH DILUTION; CASE REPORT; CORYNEBACTERIUM INFECTION; CORYNEBACTERIUM STRIATUM; DEBRIDEMENT; DEHYDRATION; DISSEMINATED FUSARIOSIS; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; ENDOSCOPIC SINUS SURGERY; ENTEROCOCCAL INFECTION; ENTEROCOCCUS FAECALIS; FEMALE; FEVER; FUNGAL SINUSITIS; FUSARIOSIS; FUSARIUM; GRANULOCYTE TRANSFUSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOTENSION; KIDNEY FAILURE; LEUKOCYTOSIS; MINIMUM INHIBITORY CONCENTRATION; NEUTROPENIA; NONHUMAN; PAPULE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SCROTUM DISORDER; SICKLE CELL ANEMIA; SKIN BIOPSY; SKIN DEFECT; THROMBOCYTOPENIA; TOOTH ABSCESS;

ADULT; CHEMOPREVENTION; FEMALE; FUSARIUM; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED; MYCOSES; TRIAZOLES;

FUSARIUM;

EID: 79953858128     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02325-10     Document Type: Article

References (12)

1. Cornely, O. A., et al. 2007. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N. Engl. J. Med. 356:348-359. (Pubitemid 46148777)
2. Frampton, J. E., and L. J. Scott. 2008. Posaconazole: a review of its use in the prophylaxis of invasive fungal infections. Drugs 68:993-1016. (Pubitemid 351652926)
3. Lewis, R., H. Hogan, A. Howell, and A. Safdar. 2008. Progressive fusariosis: unpredictable posaconazole bioavailability, and feasibility of recombinant interferon-gamma plus granulocyte macrophage-colony stimulating factor for refractory disseminated infection. Leuk. Lymphoma 49:163-165. (Pubitemid 351146899)
4. Maertens, J. 2007. Evaluating prophylaxis of invasive fungal infections in patients with haematologic malignancies. Eur. J. Haematol. 78:275-282. (Pubitemid 46365078)
5. Malani, A. N., and C. A. Kauffman. 2007. Changing epidemiology of rare mould infections: implications for therapy. Drugs 67:1803-1812. (Pubitemid 47347394)
6. Nucci, M., and E. Anaissie. 2007. Fusarium infections in immunocompromised patients. Clin. Microbiol. Rev. 20:695-704. (Pubitemid 47623773)
7. Nucci, M., et al. 2003. Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer 98:315-319. (Pubitemid 36828456)
8. Pfaller, M. A., and D. J. Diekema. 2010. Epidemiology of invasive mycoses in North America. Crit. Rev. Microbiol. 36:1-53.
9. Raad, I. I., et al. 2006. Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions. Clin. Infect. Dis. 42:1398-1403.
10. Rachwalski, E. J., J. T. Wieczorkiewicz, and M. H. Scheetz. 2008. Posaconazole: an oral triazole with an extended spectrum of activity. Ann. Pharmacother. 42:1429-1438.
11. Segal, B. H., et al. 2008. Prevention and treatment of cancer-related infections. J. Natl. Compr. Canc. Netw. 6:122-174. (Pubitemid 351340523)
12. Ullmann, A. J., et al. 2007. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N. Engl. J. Med. 356:335-347. (Pubitemid 46148776)