C4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative

Nephrology Dialysis Transplantation

Volumn 26, Issue 4, 2011, Pages 1388-1392

  David Neto, Elias ^a   David, Daisa S R ^a   Ginani, Giordano F ^a   Rodrigues, Helcio ^a   Souza, Patricia S ^a   Castro, Maria Cristina R ^a   Kanashiro, Hideki ^a   Saito, Fernando ^a   Falci, Renato ^a   Antonopoulos, Ioannis M ^a   Piovesan, Afonso Celso ^a   Nahas, William C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

antibody mediated rejection; C4d staining; complement activation; renal transplantation

Indexed keywords

COMPLEMENT COMPONENT C4D;

ACUTE ANTIBODY MEDIATED REJECTION; ACUTE GRAFT REJECTION; ADULT; ARTICLE; CLINICAL ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY CROSSMATCHING; CONTROLLED STUDY; EARLY DIAGNOSIS; FEMALE; HLA MATCHING; HUMAN; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; KIDNEY BLOOD VESSEL; KIDNEY POST REPERFUSION BIOPSY; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CAPILLARY; MALE; PRIORITY JOURNAL; STAINING; TREATMENT INDICATION;

ADOLESCENT; ADULT; BIOPSY; COMPLEMENT C4B; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HUMANS; ISOANTIBODIES; KIDNEY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROSPECTIVE STUDIES; REPERFUSION;

EID: 79953856842     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq549     Document Type: Article

References (18)

1. Margreiter R. Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study. Lancet 2002; 359: 741-746 (Pubitemid 34215073)
2. Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753-760 (Pubitemid 351347767)
3. Collins AB, Schneeberger EE, Pascual MA et al. Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208-2214 (Pubitemid 29453499)
4. Nickeleit V, Zeiler M, Gudat Fet al. Detection of the complement degradation product C4d in renal allografts: diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251 (Pubitemid 34042034)
5. David-Neto E, Prado E, Beutel A et al. C4d-positive chronic rejection: a frequent entity with a poor outcome. Transplantation 2007; 84: 1391-1398 (Pubitemid 350294713)
6. Scornik JC, Salomon DR, Lim PB et al. Posttransplant antidonor antibodies and graft rejection. Evaluation by two-color flow cytome-try. Transplantation 1989; 47: 287-290 (Pubitemid 19069706)
7. Casadei DH, del CRM, Opelz G et al. A randomized and prospective study comparing treatment with high-dose intravenous immuno-globulin with monoclonal antibodies for rescue of kidney grafts with steroid-resistant rejection. Transplantation 2001; 71: 53-58 (Pubitemid 32105778)
8. Lefaucheur C, Nochy D, Hill GS et al. Determinants of poor graft outcome in patients with antibody-mediated acute rejection. Am J Transplant 2007; 7: 832-841 (Pubitemid 46481179)
9. Tanriover B, Wright SE, Foster SV et al. High-dose intravenous im-munoglobulin and rituximab treatment for antibody-mediated rejection after kidney transplantation: a cost analysis. Transplant Proc 2008; 40: 3393-3396
10. Locke JE, Magro CM, Singer AL et al. The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection. Am J Transplant 2009; 9: 231-235
11. Akalin E, Dinavahi R, Friedlander R et al. Addition of plasmapher-esis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies. Clin J Am Soc Nephrol 2008; 3: 1160-1167
12. Locke JE, Zachary AA, Haas M et al. The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection. Am J Transplant 2007; 7: 842-846 (Pubitemid 46481192)
13. Jordan SC, Vo AA, Tyan D et al. Current approaches to treatment of antibody-mediated rejection. Pediatr Transplant 2005; 9: 408-415 (Pubitemid 40780375)
14. Haas M, Ratner LE, Montgomery RA. C4d staining of perioperative renal transplant biopsies. Transplantation 2002; 74: 711-717
15. Seemayer CA, Gaspert A, Nickeleit V et al. C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques. Nephrol Dial Transplant 2007; 22: 568-576 (Pubitemid 46189903)
16. Nadasdy GM, Bott C, Cowden D et al. Comparative study for the de-tectionofperitubular capillary C4d depositioninhuman renal allografts using different methodologies. Hum Pathol 2005; 36: 1178-1185 (Pubitemid 41540394)
17. Smith RN, Kawai T, Boskovic S et al. Chronic antibody mediated rejection of renal allografts: pathological, serological and immunologic features in nonhuman primates. Am J Transplant 2006; 6: 1790-1798 (Pubitemid 44026394)
18. Vakeva A, Morgan BP, Tikkanen I et al. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Am J Pathol 1994; 144: 1357-1368 (Pubitemid 24172098)