The bone tissue compatibility of a new Ti-Nb-Sn alloy with a low Young's modulus

Acta Biomaterialia

Volumn 7, Issue 5, 2011, Pages 2320-2326

  Miura, Keiki ^a   Yamada, Norikazu ^a   Hanada, Shuji ^b   Jung, Taek Kyun ^c   Itoi, Eiji ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Biocompatibility; Bone tissue compatibility; Cytotoxicity; Low Young's modulus; Type titanium alloy

Indexed keywords

ALUMINUM ALLOYS; BIOCOMPATIBILITY; BONE; CELL CULTURE; CELLS; CYTOTOXICITY; ELASTIC MODULI; HEAT TREATMENT; HIGH STRENGTH ALLOYS; MEDICAL APPLICATIONS; METAL IMPLANTS; METALS; NIOBIUM ALLOYS; TENSILE STRENGTH; TERNARY ALLOYS; TIN ALLOYS;

BONE TISSUE; BONE TISSUE COMPATIBILITY; DIRECT CONTACT; LOW YOUNG'S MODULUS; METAL RODS; MODULUS STRENGTH; TISSUE COMPATIBILITY; TITANIUM (ALLOYS); Β'' TYPE; Β-TYPE TITANIA ALLOY;

TITANIUM ALLOYS;

ALLOY; NIOBIUM; TIN; TITANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE TISSUE; CELL CULTURE; CONTROLLED STUDY; CORTICAL BONE; CYTOTOXICITY; ELASTICITY; EVALUATION; FEMUR; GROWTH; HISTOLOGY; MALE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; YOUNG MODULUS;

ORYCTOLAGUS CUNICULUS;

EID: 79953850793     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.02.008     Document Type: Article

References (35)

1. Niinomi M, Hattori T, Morikawa K, Kasuga T, Suzuki A, Fukui H, et al. Development of low rigidity β-type titanium alloy for biomedical applications. Mater Trans 2002;43:2970-7.
2. Head WC, Bauk DJ, Emerson Jr RH. Titanium as the material of choice for cementless femoral components in total hip arthroplasty. Clin Orthop Relat Res 1995;311:85-90.
3. Long M, Rack HJ. Titanium alloys in total joint replacement - a materials science perspective. Biomaterials 1998;19:1621-39. (Pubitemid 28512843)
4. Mont MA, Hungerford DS. Proximally coated ingrowth prostheses. A review. Clin Orthop Relat Res 1997;344:139-49.
5. Nourbash PS, Paprosky WG. Cementless femoral design concerns. Rationale for extensive porous coating. Clin Orthop Relat Res 1998;355:189-99.
6. Glassman AH, Bobyn JD, Tanzer M. New femoral designs. Do they influence stress shielding? Clin Orthop Relat Res 2006;453:64-74.
7. Niinomi M. Recent metallic materials for biomedical applications. Met Mater Trans A 2002;33A:477-86.
8. Takahashi E, Sakurai T, Watanabe S, Masahashi N, Hanada S. Effect of heat treatment and Sn content on superelasticity in biocompatible TiNbSn alloys. Mater Trans 2002;43:2978-83.
9. Hanada S, Ozaki T, Takahashi E, Watanabe S, Yoshimi K, Abumiya T. Composition dependence of Young's modulus in beta titanium alloys. Mater Sci Forum 2003;426-432:3103-8.
10. Ozaki T, Matsumoto H, Watanabe S, Hanada S. Beta Ti alloys with low Young's modulus. Mater Trans 2004;45:2776-9.
11. Matsumoto H, Watanabe S, Hanada S. Beta TiNbSn alloys with low young's modulus and high strength. Mater Trans 2005;46:1070-8. (Pubitemid 41006078)
12. Matsumoto H, Watanabe S, Hanada S. Strengthening of low Young's modulus beta Ti-Nb-Sn alloys by thermomechanical processing. In: Venugopalan R, Wu M, editors. Medical device materials III: proceedings of the materials and processes for medical devices conference. Materials Park, OH: ASM International; 2006. p. 9-14.
13. Matsumoto H, Watanabe S, Masahashi N, Hanada S. Composition dependence of Young's modulus in Ti-V, Ti-Nb, and Ti-V-Sn alloys. Met Mater Trans A 2006;37A:3239-49.
14. Matsumoto H, Watanabe S, Hanada S. Microstructures and mechanical properties of metastable β TiNbSn alloys cold rolled and heat treated. J Alloys Compd 2007;439:146-55. (Pubitemid 46765108)
15. Nozoe F, Matsumoto H, Jung TK, Watanabe S, Saburi T, Hanada S. Effect of low temperature aging on superelastic behavior in biocompatible β TiNbSn alloy. Mater Trans 2007;48:3007-13.
16. Jung TK, Abumiya T, Masahashi N, Kim MS, Hanada S. Fabrication of a high performance Ti Alloy implant for an artificial hip joint. Mater Sci Forum 2009;620-622:591-4.
17. Jung TK, Matsumoto H, Abumiya T, Masahashi N, Kim MS, Hanada S. Mechanical properties-graded Ti alloy implants for orthopedic applications. Mater Sci Forum 2010;631-632:205-10.
18. Niinomi M. Mechanical biocompatibilities of titanium alloys for biomedical applications. J Mech Behav Biomed Mater 2008;1:30-42. (Pubitemid 47557535)
19. Zheng YF, Wang BL, Wang JG, Li C, Zhao LC. Corrosion behaviour of Ti-Nb-Sn shape memory alloys in different simulated body solutions. Mater Sci Eng A 2006;438-440:891-5. (Pubitemid 44645342)
20. Frost HM. Preparation of thin undecalcified bone sections by rapid manual method. Stain Technol 1958;33:273-7.
21. Lakstein D, Kopelovitch W, Barkay Z, Bahaa M, Hendel D, Eliaz N. Enhanced osseointegration of grit-blasted, NaOH-treated and electrochemically hydroxyapatite-coated Ti-6Al-4V implants in rabbits. Acta Biomater 2009;5:2258-69.
22. Jinno T, Goldberg VM, Davy D, Stevenson S. Osseointegration of surface-blasted implants made of titanium alloy and cobalt-chromium alloy in a rabbit intramedullary model. J Biomed Mater Res 1998;42:20-9. (Pubitemid 28412993)
23. Ito A, Okazaki Y, Tateishi T, Ito Y. In vitro biocompatibility, mechanical properties, and corrosion resistance of Ti-Zr-Nb-Ta-Pd and Ti-Sn-Nb-Ta-Pd alloys. J Biomed Mater Res 1995;29:893-9.
24. Okazaki Y, Rao S, Tateishi T, Ito Y. Cytocompatibility of various metal and development of new titanium alloys for medical implants. Mater Sci Eng A 1998;243:250-6. (Pubitemid 128406832)
25. Okazaki Y, Rao S, Ito Y, Tateishi T. Corrosion resistance, mechanical properties, corrosion fatigue strength and cytocompatibility of new Ti alloys without Al and V. Biomaterials 1998;19:1197-215. (Pubitemid 28395142)
26. Okazaki Y. A new Ti-15Zr-4Nb-4Ta alloy for medical applications. Curr Opin Solid State Mater Sci 2001;5:45-53. (Pubitemid 32320602)
27. Wang X, Li Y, Hodgson PD, Wen C. Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering. Tissue Eng Part A 2010;16:309-16.
28. Li Y, Xiong J, Wong CS, Hodgson PD, Wen C. Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering. Tissue Eng Part A 2009;15:3151-9.
29. Oron A, Agar G, Oron U, Stein A. Correlation between rate of bony ingrowth to stainless steel, pure titanium, and titanium alloy implants in vivo and formation of hydroxyapatite on their surfaces in vitro. J Biomed Mater Res A 2009;91A:1006-9.
30. Wang H, Eliaz N, Xiang Z, Hsu HP, Spector M, Hobbs LW. Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy. Biomaterials 2006;27:4192-203.
31. Nishiguchi S, Fujibayashi S, Kim HM, Kokubo T, Nakamura T. Biology of alkali-and heat-treated titanium implants. J Biomed Mater Res A 2003;67A:26-35. (Pubitemid 37517151)
32. Friedman RJ, An YH, Ming J, Draughn RA, Bauer TW. Influence of biomaterial surface texture on bone ingrowth in the rabbit femur. J Orthop Res 1996;14:455-64. (Pubitemid 26199835)
33. Lin DJ, Chuang CC, Chern Lin JH, Lee JW, Ju CP, Yin HS. Bone formation at the surface of low modulus Ti-7.5Mo implants in rabbit femur. Biomaterials 2007;28:2582-9.
34. Niinomi M. Metallic biomaterials. J Artif Organs 2008;11:105-10.
35. Harvey EJ, Bobyn JD, Tanzer M, Stackpool GJ, Krygier JJ, Hacking SA. Effect of flexibility of the femoral stem on bone-remodeling and fixation of the stem in a canine total hip arthroplasty model without cement. J Bone Joint Surg Am 1999;81A:93-107. (Pubitemid 29068452)