Development, characterization and optimization of ibuprofen self-emulsifying drug delivery system applying face centered experimental design

International Journal of Pharmacy and Technology

Volumn 3, Issue 1, 2011, Pages 1674-1693

  Zaghloul, Abdelazim ^a   Aly Nada, A ^a   Khattab, Ibrahim ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Experimental design; Ibuprofen; Optimization; Self Emulsifying Drug Delivery System (SEDDS)

Indexed keywords

CREMOPHOR; IBUPROFEN; OCTANOIN; SOYBEAN OIL;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; EMULSION; EXCIPIENT COMPATIBILITY; EXPERIMENTAL DESIGN; PARTICLE SIZE; PHASE SEPARATION; PROCESS OPTIMIZATION; SELF EMULSIFYING DRUG DELIVERY SYSTEM; TURBIDITY;

EID: 79953847255     PISSN: None     EISSN: 0975766X     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Patravale VB, Date AA, Kulkarni RM. Nanosuspensions: a promising drug delivery strategy. J Pharm Pharmacol. 2004;56:827-840.
2. Robinson JR. Introduction: Semi-solid formulations for oral drug delivery. BT Gattefosse. 1996;89:11-3.
3. Kocbek P, Baumgartner S, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int J Pharm. 2006;312:179-186.
4. Devani M, Ashford M, Craig DQ. The emulsification and solubilization properties of polyglycolysed oils in self-emulsifying formulations. J Pharm Pharmacol. 2004; 56:307-316.
5. Shah NH, Caravajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in-vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994;106:15-23.
6. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, Kim DD, Jee JP, Lee YB, Woo JS, Yong CS, Choi HG. Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm. 2009:374:66-72.
7. Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z, Gagnon J, Gates B, Leon CG, Wasan KM. Development and characterization of oral lipid-based Amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm. 2009;372:76-84.
8. Atef E, Belmonte AA. Formulation and in vitro and in vivo characterization of a phenytoin selfemulsifying drug delivery system (SEDDS). Eur J Pharm Sci. 2008;35:257-63.
9. Taha E, Ghorab D, Zaghloul A. Bioavailability assessment of vitamin A self-nano emulsified drug delivery systems in rats: A comparative study. Med Princ Pract. 2007;16:355-9.
10. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Hong MJ, Jee JP, Kim JA, Yoo BK, Woo JS, Yong CS, Choi HG. Enhanced oral bioavailability of dexibuprofen by a novel solid SEDDS formulation. Eur J Pharm Biopharm. 2009;72:539-45.
11. Neslihan G, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58:173-182.
12. Rasenack N, Muller BW. Crystal habit and tableting behavior. Int J Pharm. 2002;244:45-57.
13. Majid Khan G, Zhu JB. Studies on drug kinetics from ibuprofen-carbomer hydrophilic matrix tablets: influence of co-excipients on release rate of the drug. J Control Release. 1999; 57:197-203.
14. Paavola A, Kilpelainen I, Yliruusi J, Rosenberg P. Controlled release injectable liposomal gel of ibuprofen for epidural analgesia. Int. J. Pharm. 2000;199:85-93.
15. Ozdemir N, Sahin J. Design of a controlled release osmotic pump system of ibuprofen. Int J Pharm. 1997; 158:91-97.
16. Sipahigil O, Dortunc B. Preparation and in vitro evaluation of verapamil HCl and ibuprofen containing carrageenan beads. Int J Pharm. 2001;228:119-128.
17. Nada A, Al-Saidan S, Mueller B. Improving the Physical and Chemical Properties of Ibuprofen. Pharm Technol. 2005; 29:1-8.
18. Tamilvanan S, Sa B. Studies on the in vitro release characteristics of ibuprofen-loaded polystyrene microparticles. J Microencapsul. 2000;17:57-67.
19. Pignatello R, Bucolo C, Ferrara P. Eudragit RS 100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen. Eur J Pharm Sci. 2002;16:53-61.
20. Hiroshi A, Mikio T, Masahiro H. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm. 2005; 305:61-74.
21. Araya H, Tomita M, Hayashi M. The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion III: the permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the using chamber method. Drug Metab Pharmacokinet. 2006; 21:45-53.
22. Product Information on Capmul MCM C8, ABITEC bulletin, version #7, 7/28/04, from Abitec Corp.
23. Gershanika T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm. 2000;50:179-188.
24. Chanana GD, Sheth BB. Particle size reduction of emulsions by formulation design. II: effect of oil and surfactant concentration. J Pharm Sci Technol. 1995;49:71-6.
25. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12:1561-1572.