Multiscale modelling and simulation investigation of variability and abnormalities in repolarization: Application to drug cardiotoxicity

Computing in Cardiology

Volumn 37, Issue , 2010, Pages 257-260

  Rodriguez, Blanca ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL VARIABILITY; CARDIAC ELECTROPHYSIOLOGY; CARDIOTOXICITY; IN-VITRO; MULTI-SCALE MODELLING; PHARMACEUTICAL INDUSTRY; REGULATORY AGENCIES; REPOLARIZATION; SIDE EFFECT;

CARDIOLOGY; ELECTROPHYSIOLOGY; HEART;

DRUG INTERACTIONS;

EID: 79953809850     PISSN: 23258861     EISSN: 2325887X     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (10)

1. Rodriguez B, Burrage K, Gavaghan D, Grau V, Kohl P, Noble D. The systems biology approach to drug development: Application to toxicity assessment of drug toxicity. Clinical Pharmacology and Therapeutics, 2010 (doi:10.1038/clpt.2010. 95).
2. Pitt-Francis J, Prasmanathan P, Bernabeu MO, Bordas R, Cooper J, Fletcher A, Mirams GR, Murray P, Osbourne JM, Walter A, Chapman J, Garny A, van Leeuwen I, Maini PK, Rodriguez B, Waters SL, Whiteley JP, Byrne HM, Gavaghan DJ. Chaste: a test-driven approach to software development for biological modelling. Computer Physics Communications 2009;180:2452-2472.
3. Gonzalez R, Gomis-Tena J, Corrias A, Ferrero JM, Rodriguez B, Saiz J. Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells. IEEE EMBS, 2010.
4. Walmsley J, Mirams G, Bahoshy M, Bollensdorff C, Rodriguez B, Burrage K. Phenomenological modelling of cell-to-cell and beat-to-beat variability in isolated guinea-pig ventricular myocytes. IEEE EMBS, 2010.
5. Romero L, Pueyo E, Fink M, Rodriguez B. Impact of biological variability on human ventricular cellular electrophysiology. Am J Physiol Heart Circ 2009;297: H1436-H1445.
6. Romero L, Carbonell B, Trenor B, Rodriguez B, Saiz J, Ferrero JM. Inter-species comparison of ionic mechanisms of arrhythmic risk in rabbit and human. Heart Rhythm, 2010.
7. Sanchez C, Corrias A, Laguna P, Pueyo E, Rodriguez B. Sensitivity of atrial fibrillation related biomarkers to changes in ionic current properties. Heart Rhythm, 2010.
8. Corrias A, Rodriguez B. A novel biophysically-detailed mathematical model of rabbit Purkinje cell electrophysiology. IEEE EMBS, 2010.
9. Corrias A, Pueyo E, Burrage K, Rodriguez B. Causes of variability in ventricular repolarization: from isolated cells to ECG. Heart Rhythm, 2010.
10. Bordas R, Grau V, Burton RAB, Hales P, Schneider J, Gavaghan D, Kohl P, Rodriguez B. Integrated approach for the study of anatomical variability in the cardiac purkinje system: from high resolution MRI to electrophysiology simulation. IEEE EMBS, 2010.