Optimising orifice geometry for selective release of periplasmic products during cell disruption by hydrodynamic cavitation

Biochemical Engineering Journal

Volumn 54, Issue 3, 2011, Pages 207-209

  Balasundaram, B ^a,b   Harrison, S T L ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b PLYMOUTH MARINE LABORATORY   (United Kingdom)

Author keywords

Cell disruption; Hydrodynamic cavitation; Orifice geometry; Selective release

Indexed keywords

BIOPHARMACEUTICAL PRODUCTS; CELL DEBRIS; CELL DISRUPTION; CIRCULAR ORIFICES; DOWNSTREAM-PROCESSING; E. COLI; HYDRODYNAMIC CAVITATION; HYDRODYNAMIC CAVITATIONS; JET STREAMS; MANUFACTURING COST; MECHANICAL METHODS; ORIFICE GEOMETRIES; ORIFICE GEOMETRY; ORIFICE PLATE; PERIPLASMIC PROTEINS; PROCESS ECONOMICS; PRODUCT STREAMS; SELECTIVE RELEASE;

CAVITATION; DEBRIS; ESCHERICHIA COLI; FLUID DYNAMICS; GEOMETRY; HYDRAULICS; HYDRODYNAMICS;

ORIFICES;

PERIPLASMIC PROTEIN;

ARTICLE; BACTERIAL CELL; CELL DISRUPTION; EQUIPMENT DESIGN; ESCHERICHIA COLI; FLOW RATE; GEOMETRY; HYDRODYNAMIC CAVITATION; HYDRODYNAMICS; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS;

EID: 79953800504     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2011.03.002     Document Type: Article

References (10)

1. Zhou Y.H., Titchener-Hooker N.J. Visualizing integrated bioprocess designs through windows of operation. Biotechnol. Bioeng. 2000, 65:550-557.
2. Agerkvist I., Enfors S.-O. Characterization of E. coli cell disintegrates from a bead mill and high pressure homogenizers. Biotechnol. Bioeng. 1990, 36:1083-1089.
3. Lee C.T., Morreale G., Middelberg A.P.J. Combined in-fermenter extraction and cross-flow microfiltration for improved inclusion body processing. Biotechnol. Bioeng. 2004, 85:103-113.
4. Kee G.S., Pujar N., Titchener-Hooker N. Study of detergent-mediated liberation of hepatitis B virus-like particles from S. cerevisiae homogenate: identifying a framework for the design of future-generation lipoprotein vaccine processes. Biotechnol. Prog. 2008, 24:623-631.
5. Harrison S.T.L. Bacterial cell disruption: a key unit operation in the recovery of intracellular products. Biotechnol. Adv. 1991, 9:217-240.
6. Balasundaram B., Pandit A.B. Selective release of invertase by hydrodynamic cavitation. Biochem. Eng. J. 2001, 8:251-256.
7. Balasundaram B., Harrison S.T.L. Disruption of brewers' yeast by hydrodynamic cavitation: process variables and their influence on selective release. Biotechnol. Bioeng. 2006, 94:303-311.
8. Balasundaram B., Harrison S.T.L. Study of physical and biological factors involved in the disruption of E. coli by hydrodynamic cavitation. Biotechnol. Prog. 2006, 22:907-913.
9. Sivakumar M., Pandit A.B. Wastewater treatment: a novel energy efficient hydrodynamic cavitational technique. Ultrasonics Sonochem. 2002, 9:123-131.
10. Vichare N.P., Gogate P.R., Pandit A.B. Optimization of hydrodynamic cavitation using a model reaction. Chem. Eng. Technol. 2000, 23:683-690.