메뉴 건너뛰기




Volumn 67, Issue 3, 2011, Pages 637-646

In vitro sequence-dependent synergism between paclitaxel and gefitinib in human lung cancer cell lines

Author keywords

Epidermal growth factor receptor tyrosine kinase; Lung cancer

Indexed keywords

GEFITINIB; PACLITAXEL; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; QUINAZOLINE DERIVATIVE;

EID: 79953795924     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1347-4     Document Type: Article
Times cited : (65)

References (50)
  • 1
    • 57349182464 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control
    • 10.1093/jnci/djn389 19033571
    • A Jemal MJ Thun LA Ries, et al. 2008 Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control J Natl Cancer Inst 100 23 1672 1694 10.1093/jnci/djn389 19033571
    • (2008) J Natl Cancer Inst , vol.100 , Issue.23 , pp. 1672-1694
    • Jemal, A.1    Thun, M.J.2    Ries, L.A.3
  • 2
    • 34848849863 scopus 로고    scopus 로고
    • Treatment of non-small cell lung cancer, stage IV: ACCP evidence-based clinical practice guidelines (2nd edn)
    • 10.1378/chest.07-1381 17873174
    • MA Socinski R Crowell TE Hensing, et al. 2007 Treatment of non-small cell lung cancer, stage IV: ACCP evidence-based clinical practice guidelines (2nd edn) Chest 132 3 Suppl 277S 289S 10.1378/chest.07-1381 17873174
    • (2007) Chest , vol.132 , Issue.3 SUPPL.
    • Socinski, M.A.1    Crowell, R.2    Hensing, T.E.3
  • 3
    • 21044449609 scopus 로고    scopus 로고
    • ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of non-small-cell lung cancer (NSCLC)
    • DOI 10.1093/annonc/mdi821
    • E Felip RA Stahel N Pavlidis 2005 ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of non-small-cell lung cancer (NSCLC) Ann Oncol 16 Suppl 1 i28 i29 10.1093/annonc/mdi821 15888743 (Pubitemid 40872978)
    • (2005) Annals of Oncology , vol.16 , Issue.SUPPL. 1
    • Felip, E.1    Stahel, R.A.2    Pavlidis, N.3
  • 5
    • 0346560025 scopus 로고    scopus 로고
    • Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group - EORTC 08975
    • DOI 10.1200/JCO.2003.03.195
    • EF Smit JP van Meerbeeck P Lianes, et al. 2003 Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975 J Clin Oncol 21 21 3909 3917 1:CAS:528:DC%2BD2cXpsVajsLY%3D 10.1200/JCO.2003.03.195 14581415 (Pubitemid 46606203)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.21 , pp. 3909-3917
    • Smit, E.F.1    Van Meerbeeck, J.P.A.M.2    Lianes, P.3    Debruyne, C.4    Legrand, C.5    Schramel, F.6    Smit, H.7    Gaafar, R.8    Biesma, B.9    Manegold, C.10    Neymark, N.11    Giaccone, G.12
  • 8
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • 1:CAS:528:DC%2BD1cXhsVWhtbjM 10.1016/S0140-6736(08)61758-4 19027483
    • ES Kim V Hirsh T Mok, et al. 2008 Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial Lancet 372 9652 1809 1818 1:CAS:528:DC%2BD1cXhsVWhtbjM 10.1016/S0140-6736(08)61758-4 19027483
    • (2008) Lancet , vol.372 , Issue.9652 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 11
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • 1:CAS:528:DC%2BD1MXhtVygsbfK 10.1056/NEJMoa0810699 19692680
    • TS Mok YL Wu S Thongprasert, et al. 2009 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 10 947 957 1:CAS:528:DC%2BD1MXhtVygsbfK 10.1056/NEJMoa0810699 19692680
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 12
    • 34249860227 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: A meta-analysis based on updated individual patient data from six medical centers in mainland China
    • DOI 10.1097/01.JTO.0000268677.87496.4c, PII 0124389420070500000011
    • YL Wu WZ Zhong LY Li, et al. 2007 Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China J Thorac Oncol 2 5 430 439 10.1097/01.JTO.0000268677.87496.4c 17473659 (Pubitemid 47181698)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.5 , pp. 430-439
    • Wu, Y.-L.1    Zhong, W.-Z.2    Li, L.-Y.3    Zhang, X.-T.4    Zhang, L.5    Zhou, C.-C.6    Liu, W.7    Jiang, B.8    Mu, X.-L.9    Lin, J.-Y.10    Zhou, Q.11    Xu, C.-R.12    Wang, Z.13    Zhang, G.-C.14    Mok, T.15
  • 13
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • PB Schiff J Fant SB Horwitz 1979 Promotion of microtubule assembly in vitro by taxol Nature 277 5698 665 667 1:CAS:528:DyaE1MXkvVCitrY%3D 10.1038/277665a0 423966 (Pubitemid 9114288)
    • (1979) Nature , vol.277 , Issue.5698 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 14
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor- selective tyrosine kinase inhibitor
    • F Ciardiello R Caputo R Bianco, et al. 2000 Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor Clin Cancer Res 6 5 2053 2063 1:CAS:528:DC%2BD3cXktVWitrs%3D 10815932 (Pubitemid 30305105)
    • (2000) Clinical Cancer Research , vol.6 , Issue.5 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De Placido, S.6    Bianco, A.R.7    Tortora, G.8
  • 15
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • FM Sirotnak MF Zakowski VA Miller HI Scher MG Kris 2000 Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase Clin Cancer Res 6 12 4885 4892 1:CAS:528:DC%2BD3MXotlektQ%3D%3D 11156248 (Pubitemid 32110433)
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 18
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1-2 55 63 1:STN:280:DyaL2c%2FovFSmtw%3D%3D 10.1016/0022-1759(83)90303-4 6606682 (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 19
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • J Carmichael WG DeGraff AF Gazdar JD Minna JB Mitchell 1987 Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing Cancer Res 47 4 936 942 1:CAS:528:DyaL2sXhsVyrtb0%3D 3802100 (Pubitemid 17027905)
    • (1987) Cancer Research , vol.47 , Issue.4 , pp. 936-942
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3
  • 21
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • DOI 10.1124/pr.58.3.10
    • TC Chou 2006 Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacol Rev 58 3 621 681 1:CAS:528:DC%2BD28XhtVOhtLfL 10.1124/pr.58.3.10 16968952 (Pubitemid 44403686)
    • (2006) Pharmacological Reviews , vol.58 , Issue.3 , pp. 621-681
    • Chou, T.-C.1
  • 22
    • 0032529464 scopus 로고    scopus 로고
    • Mechanisms of taxol-induced cell death are concentration dependent
    • K Torres SB Horwitz 1998 Mechanisms of Taxol-induced cell death are concentration dependent Cancer Res 58 16 3620 3626 1:CAS:528:DyaK1cXlsFajt7o%3D 9721870 (Pubitemid 28376560)
    • (1998) Cancer Research , vol.58 , Issue.16 , pp. 3620-3626
    • Torres, K.1    Horwitz, S.B.2
  • 23
    • 0014119864 scopus 로고
    • Properties of mitotic cells prepared by mechanically shaking monolayer cultures of Chinese hamster cells
    • 1:STN:280:DyaF1c3gt1Wiug%3D%3D 10.1002/jcp.1040700109 4869346
    • RA Tobey EC Anderson DF Petersen 1967 Properties of mitotic cells prepared by mechanically shaking monolayer cultures of Chinese hamster cells J Cell Physiol 70 1 63 68 1:STN:280:DyaF1c3gt1Wiug%3D%3D 10.1002/jcp.1040700109 4869346
    • (1967) J Cell Physiol , vol.70 , Issue.1 , pp. 63-68
    • Tobey, R.A.1    Anderson, E.C.2    Petersen, D.F.3
  • 24
    • 0345275866 scopus 로고    scopus 로고
    • Gene Expression and Mitotic Exit Induced by Microtubule-Stabilizing Drugs
    • JG Chen CP Yang M Cammer SB Horwitz 2003 Gene expression and mitotic exit induced by microtubule-stabilizing drugs Cancer Res 63 22 7891 7899 1:CAS:528:DC%2BD3sXptFOlt7k%3D 14633718 (Pubitemid 37466724)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7891-7899
    • Chen, J.-G.1    Yang, C.-P.H.2    Cammer, M.3    Horwitz, S.B.4
  • 25
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    • 1:CAS:528:DC%2BD1cXhtVSrtrjN 10.1016/j.ccr.2008.07.002 18656424
    • KE Gascoigne SS Taylor 2008 Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs Cancer Cell 14 2 111 122 1:CAS:528:DC%2BD1cXhtVSrtrjN 10.1016/j.ccr.2008.07.002 18656424
    • (2008) Cancer Cell , vol.14 , Issue.2 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 26
    • 7744233719 scopus 로고    scopus 로고
    • Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
    • DOI 10.1016/j.devcel.2004.09.002, PII S1534580704003016
    • CL Rieder H Maiato 2004 Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint Dev Cell 7 5 637 651 1:CAS:528:DC%2BD2cXhtVWgsLnK 10.1016/j.devcel.2004.09.002 15525526 (Pubitemid 39462685)
    • (2004) Developmental Cell , vol.7 , Issue.5 , pp. 637-651
    • Rieder, C.L.1    Maiato, H.2
  • 27
    • 69549120405 scopus 로고    scopus 로고
    • How do anti-mitotic drugs kill cancer cells?
    • 1:CAS:528:DC%2BD1MXhtVGhsL7F 10.1242/jcs.039719 19625502
    • KE Gascoigne SS Taylor 2009 How do anti-mitotic drugs kill cancer cells? J Cell Sci 122 Pt 15 2579 2585 1:CAS:528:DC%2BD1MXhtVGhsL7F 10.1242/jcs.039719 19625502
    • (2009) J Cell Sci , vol.122 , Issue.PART 15 , pp. 2579-2585
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 28
    • 33744996707 scopus 로고    scopus 로고
    • Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint
    • DOI 10.1016/j.cub.2006.04.043, PII S0960982206015405
    • DA Brito CL Rieder 2006 Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint Curr Biol 16 12 1194 1200 1:CAS:528:DC%2BD28XlvF2jtrk%3D 10.1016/j.cub.2006.04.043 16782009 (Pubitemid 43867292)
    • (2006) Current Biology , vol.16 , Issue.12 , pp. 1194-1200
    • Brito, D.A.1    Rieder, C.L.2
  • 29
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
    • MA Jordan K Wendell S Gardiner WB Derry H Copp L Wilson 1996 Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death Cancer Res 56 4 816 825 1:CAS:528:DyaK28XhtVClsbo%3D 8631019 (Pubitemid 26055472)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 30
    • 0030451851 scopus 로고    scopus 로고
    • Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state
    • DOI 10.1016/S0027-5107(96)00138-8, PII S0027510796001388
    • PR Andreassen SN Martineau RL Margolis 1996 Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state Mutat Res 372 2 181 194 1:CAS:528:DyaK28Xnt1Oitbo%3D 9015137 (Pubitemid 27039398)
    • (1996) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.372 , Issue.2 , pp. 181-194
    • Andreassen, P.R.1    Martineau, S.N.2    Margolis, R.L.3
  • 31
    • 70349452101 scopus 로고    scopus 로고
    • Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly
    • 1:CAS:528:DC%2BD1MXhsVCjtrnN 10.1016/j.ccr.2009.08.020 19800579
    • HC Huang J Shi JD Orth TJ Mitchison 2009 Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly Cancer Cell 16 4 347 358 1:CAS:528:DC%2BD1MXhsVCjtrnN 10.1016/j.ccr.2009.08.020 19800579
    • (2009) Cancer Cell , vol.16 , Issue.4 , pp. 347-358
    • Huang, H.C.1    Shi, J.2    Orth, J.D.3    Mitchison, T.J.4
  • 32
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • DOI 10.1126/science.1101637
    • R Sordella DW Bell DA Haber J Settleman 2004 Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways Science 305 5687 1163 1167 1:CAS:528:DC%2BD2cXmslCmur8%3D 10.1126/science.1101637 15284455 (Pubitemid 39100331)
    • (2004) Science , vol.305 , Issue.5687 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 33
    • 5644293135 scopus 로고    scopus 로고
    • L858R non-small-cell lung cancer cell line H3255
    • DOI 10.1158/0008-5472.CAN-04-1905
    • S Tracy T Mukohara M Hansen M Meyerson BE Johnson PA Janne 2004 Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255 Cancer Res 64 20 7241 7244 1:CAS:528:DC%2BD2cXosFynt7w%3D 10.1158/0008-5472.CAN- 04-1905 15492241 (Pubitemid 39372059)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7241-7244
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3    Meyerson, M.4    Johnson, B.E.5    Janne, P.A.6
  • 34
    • 4444286324 scopus 로고    scopus 로고
    • Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells
    • DOI 10.1016/j.bcp.2004.06.006, PII S0006295204004204
    • GC Chang SL Hsu JR Tsai, et al. 2004 Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells Biochem Pharmacol 68 7 1453 1464 1:CAS:528:DC%2BD2cXntlemt7Y%3D 10.1016/j.bcp.2004.06.006 15345335 (Pubitemid 39179402)
    • (2004) Biochemical Pharmacology , vol.68 , Issue.7 , pp. 1453-1464
    • Chang, G.-C.1    Hsu, S.-L.2    Tsai, J.-R.3    Liang, F.-P.4    Lin, S.-Y.5    Sheu, G.-T.6    Chen, C.-Y.7
  • 36
    • 0029913172 scopus 로고    scopus 로고
    • Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
    • 1:CAS:528:DyaK28Xitlyks7Y%3D 8620503
    • MV Blagosklonny T Schulte P Nguyen J Trepel LM Neckers 1996 Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway Cancer Res 56 8 1851 1854 1:CAS:528:DyaK28Xitlyks7Y%3D 8620503
    • (1996) Cancer Res , vol.56 , Issue.8 , pp. 1851-1854
    • Blagosklonny, M.V.1    Schulte, T.2    Nguyen, P.3    Trepel, J.4    Neckers, L.M.5
  • 38
    • 0035992286 scopus 로고    scopus 로고
    • Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition
    • JP MacKeigan DJ Taxman D Hunter HS Earp III LM Graves JP Ting 2002 Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition Clin Cancer Res 8 7 2091 2099 1:CAS:528:DC%2BD38XmtVWitb8%3D 12114408 (Pubitemid 34753578)
    • (2002) Clinical Cancer Research , vol.8 , Issue.7 , pp. 2091-2099
    • MacKeigan, J.P.1    Taxman, D.J.2    Hunter, D.3    Earp III, H.S.4    Graves, L.M.5    Ting, J.P.-Y.6
  • 39
    • 0034920013 scopus 로고    scopus 로고
    • Selective potentiation of paclitaxel (Taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines
    • HM McDaid SB Horwitz 2001 Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines Mol Pharmacol 60 2 290 301 1:CAS:528: DC%2BD3MXlsFansbg%3D 11455016 (Pubitemid 32678294)
    • (2001) Molecular Pharmacology , vol.60 , Issue.2 , pp. 290-301
    • McDaid, H.M.1    Horwitz, S.B.2
  • 40
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y et al (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11(2):121-128
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 41
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • 1:CAS:528:DC%2BD2MXhtVKgtbzN 10.1200/JCO.2005.02.840 16043829
    • RS Herbst D Prager R Hermann, et al. 2005 TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer J Clin Oncol 23 25 5892 5899 1:CAS:528:DC%2BD2MXhtVKgtbzN 10.1200/JCO.2005.02.840 16043829
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 43
    • 24944503508 scopus 로고    scopus 로고
    • Integration of novel therapeutics into combined modality therapy of locally advanced non-small cell lung cancer
    • 1:CAS:528:DC%2BD2MXlvVGgtLo%3D 10.1158/1078-0432.CCR-05-9012 16000614
    • D Gandara S Narayan PN Lara Jr, et al. 2005 Integration of novel therapeutics into combined modality therapy of locally advanced non-small cell lung cancer Clin Cancer Res 11 13 Pt 2 5057s 5062s 1:CAS:528: DC%2BD2MXlvVGgtLo%3D 10.1158/1078-0432.CCR-05-9012 16000614
    • (2005) Clin Cancer Res , vol.11 , Issue.13 PART 2
    • Gandara, D.1    Narayan, S.2    Lara Jr., P.N.3
  • 44
    • 24944578615 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: Case closed or is the jury still out?
    • 10.1200/JCO.2005.05.030 16043825
    • DR Gandara PH Gumerlock 2005 Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: case closed or is the jury still out? J Clin Oncol 23 25 5856 5858 10.1200/JCO.2005.05.030 16043825
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 5856-5858
    • Gandara, D.R.1    Gumerlock, P.H.2
  • 45
    • 33745897599 scopus 로고    scopus 로고
    • Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in non-small-cell lung cancer
    • AM Davies C Ho PN Lara Jr P Mack PH Gumerlock DR Gandara 2006 Pharmacodynamic separation of epidermal growth factor receptor tyrosine kinase inhibitors and chemotherapy in non-small-cell lung cancer Clin Lung Cancer 7 6 385 388 1:CAS:528:DC%2BD28XmsFyqt7Y%3D 10.3816/CLC.2006.n.021 16800963 (Pubitemid 44043547)
    • (2006) Clinical Lung Cancer , vol.7 , Issue.6 , pp. 385-388
    • Davies, A.M.1    Ho, C.2    Lara Jr., P.N.3    Mack, P.4    Gumerlock, P.H.5    Gandara, D.R.6
  • 46
    • 2442523996 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of docetaxel OSI-774 combination in non-small cell lung carcinoma (NSCLC)
    • abstr 2661
    • Gumerlock PH, Pryde BJ, Kimura T (2003) Enhanced cytotoxicity of docetaxel OSI-774 combination in non-small cell lung carcinoma (NSCLC). Proc Am Soc Clin Oncol (22:abstr 2661)
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Gumerlock, P.H.1    Pryde, B.J.2    Kimura, T.3
  • 47
    • 41149096042 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
    • DOI 10.1124/mol.107.042382
    • E Giovannetti C Lemos C Tekle, et al. 2008 Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells Mol Pharmacol 73 4 1290 1300 1:CAS:528:DC%2BD1cXjvFels7k%3D 10.1124/mol.107.042382 18187583 (Pubitemid 351439211)
    • (2008) Molecular Pharmacology , vol.73 , Issue.4 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3    Smid, K.4    Nannizzi, S.5    Rodriguez, J.A.6    Ricciardi, S.7    Danesi, R.8    Giaccone, G.9    Peters, G.J.10
  • 49
    • 34250637524 scopus 로고    scopus 로고
    • Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells
    • DOI 10.1158/1078-0432.CCR-06-2923
    • T Li YH Ling ID Goldman R Perez-Soler 2007 Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells Clin Cancer Res 13 11 3413 3422 1:CAS:528:DC%2BD2sXmtVais74%3D 10.1158/1078-0432.CCR-06-2923 17545550 (Pubitemid 46944930)
    • (2007) Clinical Cancer Research , vol.13 , Issue.11 , pp. 3413-3422
    • Li, T.1    Ling, Y.-H.2    Goldman, I.D.3    Perez-Soler, R.4
  • 50
    • 75249084998 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer
    • 1:CAS:528:DC%2BD1MXhsVCrsrrI 10.1200/JCO.2008.21.5541 19738125
    • TS Mok YL Wu CJ Yu, et al. 2009 Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer J Clin Oncol 27 30 5080 5087 1:CAS:528:DC%2BD1MXhsVCrsrrI 10.1200/JCO.2008.21.5541 19738125
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5080-5087
    • Mok, T.S.1    Wu, Y.L.2    Yu, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.