Quantification of dermal and transdermal delivery of meloxicam gels in rabbits

Drug Development and Industrial Pharmacy

Volumn 37, Issue 5, 2011, Pages 613-617

  Patel, Mayurkumar ^a,b   Joshi, Abhay ^a   Hassanzadeth, Hana ^a,c   Juluru, Ravi ^a   Stagni, Grazia ^a  

^a LONG ISLAND UNIVERSITY   (United States)

^b International Trading Pharmaceutical Laboratories Inc   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

bioavailability; Meloxicam; menthol; microdialysis; transdermal delivery

Indexed keywords

HYDROXYPROPYLCELLULOSE; MELOXICAM; MENTHOL; OLEIC ACID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DERMIS; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MICRODIALYSIS; NONHUMAN; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL AVAILABILITY; CELLULOSE; DRUG DELIVERY SYSTEMS; FEMALE; GELS; MENTHOL; MICRODIALYSIS; OLEIC ACID; RABBITS; SKIN; SKIN ABSORPTION; SPECIFIC PATHOGEN-FREE ORGANISMS; THIAZINES; THIAZOLES;

EID: 79953791370     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.534098     Document Type: Article

References (18)

1. Aungst BJ. (1995). Fatty acids as skin permeation enhancers. Percutaneous Penetration Enhancers. EW Smith, HI Maibach (eds.), CRC Press: Boca Raton, pp. 277-287.
2. Benfeldt E. (1999). In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects. Acta Derm Venereol Suppl (Stockh) 206:1-59.
3. Benfeldt E, Groth L. (1998). Feasibility of measuring lipophilic or protein-bound drugs in the dermis by in vivo microdialysis after topical or systemic drug administration. Acta Derm Venereol 78:274-278. (Pubitemid 28328921)
4. Brain KR, Green DM, Dykes PJ, Marks R, Bola TS. (2006). The role of menthol in skin penetration from topical formulations of ibuprofen 5% in vivo. Skin Pharmacol Physiol 19:17-21. (Pubitemid 41759078)
5. de Lange EC, de Boer AG, Breimer DD. (2000). Methodological issues in microdialysis sampling for pharmacokinetic studies. Adv Drug Deliv Rev 45:125-148.
6. Francoeur ML, Golden GM, Potts RO. (1990). Oleic acid: its effects on stratum corneum in relation to (trans)dermal drug delivery. Pharm Res 7:621-627. (Pubitemid 20286529)
7. Gibaldi M, Perrier D. (1982). Pharmacokinetics. Drugs and the Pharmaceutical Sciences. Marcel Dekker, Inc: New York.
8. Groth L. (1998). Cutaneous microdialysis. A new technique for the assessment of skin penetration. Curr Probl Dermatol 26:90-98.
9. Heyneman CA, Lawless-Liday C, Wall GC. (2000). Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs 60:555-574.
10. Jantharaprapap R, Stagni G. (2007). Effects of penetration enhancers on in vitro permeability of meloxicam gels. Int J Pharm 343:26-33. (Pubitemid 47321008)
11. Naik A, Pechtold LA, Potts RO, Guy RH. (1995). Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans. J Control Release 37:299-306. (Pubitemid 26007540)
12. Narjes H, Türck D, Busch U, Heinzel G, Nehmiz G. (1996). Pharmacokinetics and tolerability of meloxicam after i.m. administration. Br J Clin Pharmacol 41:135-139. (Pubitemid 26059126)
13. O'Hanlon JJ, McCleane G, Muldoon T. (1996). Preoperative application of piroxicam gel compared to a local anaesthetic field block for postoperative analgesia. Acta Anaesthesiol Scand 40:715-718. (Pubitemid 26232678)
14. Sapra B, Jain S, Tiwary AK. (2008). Percutaneous permeation enhancement by terpenes: mechanistic view. AAPS J 10:120-132.
15. Schmid J, Busch U, Heinzel G, Bozler G, Kaschke S, Kummer M. (1995). Pharmacokinetics and metabolic pattern after intravenous infusion and oral administration to healthy subjects. Drug Metab Dispos 23:1206-1213.
16. Stagni G, O'Donnell D, Liu YJ, Kellogg DL Jr, Shepherd AM. (1999). Iontophoretic current and intradermal microdialysis recovery in humans. J Pharmacol Toxicol Methods 41:49-54. (Pubitemid 29465773)
17. Stagni G, Shukla C. (2003). Pharmacokinetics of methotrexate in rabbit skin and plasma after iv-bolus and iontophoretic administrations. J Control Release 93:283-292. (Pubitemid 37485950)
18. Wolfe MM, Lichtenstein DR, Singh G. (1999). Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340:1888-1899. (Pubitemid 29272670)