Is hyperchloremia associated with mortality in critically ill patients? A prospective cohort study

Journal of Critical Care

Volumn 26, Issue 2, 2011, Pages 175-179

  Boniatti, Márcio M ^a   Cardoso, Paulo R C ^a   Castilho, Rodrigo K ^a   Vieira, Silvia R R ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Acid base equilibrium; Chloride; Outcomes

Indexed keywords

ACID BASE BALANCE; ADULT; AGE; ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERCHLOREMIA; HYPOALBUMINEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; SCORING SYSTEM;

ACID-BASE EQUILIBRIUM; ADULT; AGE FACTORS; AGED; CHLORINE; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HOSPITALS, UNIVERSITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROSPECTIVE PAYMENT SYSTEM; SEPSIS; SERUM ALBUMIN;

EID: 79953767554     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2010.04.013     Document Type: Article

References (31)

1. Gunnerson K.J., Kellum J.A. Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium?. Curr Opin Crit Care 2003, 9:468-473.
2. Sirker A.A., Rhodes A., Grounds R.M., et al. Acid-base physiology: the "traditional" and the "modern" approaches. Anaesthesia 2002, 57:348-356.
3. Stewart P.A. How to understand acid base balance. A quantitative acid-base primer for biology and medicine 1981, Elsevier, New York. P.A. Stewart (Ed.).
4. Stewart P.A. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983, 61:1444-1461.
5. Figge J., Rossing T.H., Fencl V. The role of serum proteins in acid-base equilibria. J Lab Clin Med 1991, 117:453-467.
6. Figge J., Mydosh T., Fencl V. Serum proteins and acid-base equilibria: a follow-up. J Lab Clin Med 1992, 120:713-719.
7. Martin M., Murray J., Berne T., et al. Diagnosis of acid-base derangements and mortality prediction in the trauma intensive care unit: the physiochemical approach. J Trauma 2005, 58:238-243.
8. Cusack R.J., Rhodes A., Lochhead P., et al. The strong ion gap does not have prognostic value in critically ill patients in a mixed medical/surgical adult ICU. Intensive Care Med 2002, 28:864-869.
9. Balasubramanyan N., Havens P., Hoffman G. Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med 1999, 27:1577-1581.
10. Fencl V., Jabor A., Kazda A., et al. Diagnosis of metabolic acid-base disturbances in critically ill patients. Am J Resp Crit Care Med 2000, 162:2246-2251.
11. Smith I., Kumar P., Molloy S., et al. Base excess and lactate as prognostic indicators for patients admitted to intensive care. Intensive Care Med 2001, 27:74-83.
12. Waldau T., Larsen V.H., Bonde J., et al. Lactate, pH, and blood gas analysis in critically ill patients. Acta Anaesthesiol Scand 1995, 39:267-271.
13. Kaplan L.J., Kellum J.A. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med 2004, 32:1120-1124.
14. Dondorp A.M., Chau T.T.H., Phu N.H., et al. Unidentified acid of strong prognostic significance in severe malaria. Crit Care Med 2004, 32:1683-1688.
15. Story D.A. Hyperchloraemic acidosis: another misnomer?. Crit Care Resusc 2004, 6:188-192.
16. Boniatti M.M., Cardoso P.R.C., Castilho R.K., et al. Acid-base disorders evaluation in critically ill patients: we can improve our diagnostic ability. Intensive Care Med 2009, 35:1377-1382.
17. Henderson L.J. The theory of neutrality regulation in the animal organism. Am J Physiol 1908, 21:427-428.
18. Hasselbach K.A. Die Berechnung der Wasserstoffzahl des blutes auf der freien und gebundenen Kohlensaure desselben, und die Sauerstoffbindung des Blutes als Funktion der Wasserstoffzahl. Biochem Z 1916, 78:112-144.
19. Siggaard-Andersen O., Wimberly P.D., Fogh-Andersen N., et al. Measured and derived quantities with modern pH and blood gas equipment: calculation algorithms with 54 equations. Scand J Clin Lab Inves 1988, 48(Supp 189):7-15.
20. Kellum J.A. Disorders of acid-base balance. Crit Care Med 2007, 35:2630-2636.
21. Kellum J.A. Closing the gap on unmeasured anions. Crit Care 2003, 7:219-220.
22. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
23. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
24. Dubin A., Menises M.M., Massevicius F.D., et al. Comparison of three different methods of evaluation of metabolic acid-base disorders. Crit Care Med 2007, 35:1264-1270.
25. Rocktaeschel J., Morimatsu H., Uchino S., et al. Unmeasured anions in critically ill patients: can they predict mortality?. Crit Care Med 2003, 31:2131-2136.
26. Hucker T.R., Mitchell G.P., Blake L.D., et al. Identifying the sick: can biochemical measurements be used to aid decision on presentation to the accident and emergency department. Br J Anaesth 2005, 94:735-741.
27. Mangialardi R.J., Martin G.S., Bernard G.R., et al. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Crit Care Med 2000, 28:3137-3145.
28. Kellum J.A. Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved survival and acid-base balance with a synthetic colloid in a balanced electrolyte solution compared to saline. Crit Care Med 2002, 30:300-305.
29. Kellum J.A., Song M., Venkataraman R. Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis. Chest 2004, 125:243-248.
30. Funk G.C., Doberer D., Sterz F., et al. The strong ion gap and outcome after cardiac arrest in patients treated with therapeutic hypothermia: a retrospective study. Intensive Care Med 2009, 35:232-239.
31. Abramson D., Scalea T.M., Hitchcock R., et al. Lactate clearance and survival following injury. J Trauma 1993, 35:584-588.