Effects of Hyperchloremic Acidosis on Arterial Pressure and Circulating Inflammatory Molecules in Experimental Sepsis

Chest

Volumn 125, Issue 1, 2004, Pages 243-248

  Kellum, John A ^a   Song, Mingchen ^a   Venkataraman, Ramesh ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Acid base balance; Chloride; Fluid resuscitation; Metabolic acidosis; Nitric oxide; Saline; Sepsis; Septic shock

Indexed keywords

ELECTROLYTE; HYDROCHLORIC ACID; INTERLEUKIN 10; INTERLEUKIN 6; NITRATE; NITRITE; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTERIAL PRESSURE; ARTICLE; CECUM; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DISEASE SEVERITY; ELECTROLYTE BALANCE; HYPERCHLOREMIC ACIDOSIS; HYPOTENSION; INFLAMMATION; INFUSION; LIGATION; MALE; NONHUMAN; OPEN STUDY; PRIORITY JOURNAL; PUNCTURE; RANDOMIZATION; RAT; SEPSIS;

EID: 1642534555     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.125.1.243     Document Type: Article

References (35)

1. Kellum JA, Bellomo R, Kramer DJ, et al. Etiology of metabolic acidosis during saline resuscitation in endotoxemia. Shock 1998; 9:364-368
2. Scheingraber S, Rehm M, Sehmisch C, et al. Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery. Anesthesiology 1999; 90:1265-1270
3. Waters JH, Miller LR, Clack S, et al. Cause of metabolic acidosis in prolonged surgery. Crit Care Med 1999; 27:2142-2146
4. Waters JH, Bernstein CA. Dilutional acidosis following hetastarch or albumin in healthy volunteers. Anesthesiology 2000; 93:1184-1187
5. Liskaser FJ, Bellomo R, Hayhoe M, et al. Role of pump prime in the etiology and pathogenesis of cardiopulmonary bypass-associated acidosis. Anesthesiology 2000; 93:1170-1173
6. Rehm M, Orth V, Scheingraber S, et al. Acid-base changes caused by 5% albumin versus 6% hydrexyethyl starch solution in patients undergoing acute normovolemic hemodilution: a randomized prospective study. Anesthesiology 2000; 93:1174-1183
7. Stewart P. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983; 61:1444-1461
8. Kellum JA. Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved survival and acid-base balance with a synthetic colloid in a balanced electrolyte solution compared to saline. Crit Care Med 2002; 30:300-305
9. Opie L. Effect of extracellular pH on function and metabolism of isolated perfused rat heart. J Appl Physiol 1965; 209:1975-1980
10. Cooper D, Herbertson M, Werner H, et al. Bicarbonate does not increase left ventricular contractility during L-lactic acidemia in pigs. Am Rev Respir Dis 1993; 148:317-322
11. Pedoto A, Caruso JE, Nandi J. Acidosis stimulates nitric oxide production and lung damage in rats. Am J Respir Crit Care Med 1999; 159:397-402
12. Jensen JC, Buresh C, Norton JA. Lactic acidosis increases tumor necrosis factor secretion and transcription in vitro. J Surg Res 1990; 49:350-3.53
13. Tulzo YL, Shenkar R, Kaneko D. Hemorrhage increases cytokines expression in lung mononuclear cell in mice, involvement of catecholamines in nuclear factor-B regulation and cytokine expression. J Clin Invest 1997; 99:1516-1524
14. Leverve XM, Mustafa I. Lactate: a key metabolite in the intercellular metabolic interplay. Crit Care 2002; 6:284-285
15. Forsythe SM, Schmidt GA. Sodium bicarbonate for the treatment of lactic acidosis. Chest 2000; 117:260-267
16. Christiansen TF. An algorithm for calculating the concentration of the base excess of blood. In: Siggard-Andersen O, ed. Proceedings of the IFCC expert panel on pH and blood gases. Copenhagen, Denmark: Radiometer Medical A/S, 1981; 77-81
17. Kellum JA, Kramer DJ, Pinsky MR. Strong ion gap: a methodology for exploring unexplained anions. J Crit Care 1995; 10:51-55
18. Figge J, Mydosh T, Fend V. Serum proteins and acid-base equilibria: a follow-up. J Lab Clin Med 1992; 120:713-719
19. Vodovotz Y. Modified microassay for serum nitrite and nitrate. Biotechniques 1996; 20:390-394
20. Green LC, Wagner DA, Glogowsld J, et al. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982; 126:131-138
21. Pedoto A, Nandi J, Oler A, et al. Role of nitric oxide in acidosis-induced intestinal injury in anesthetized rats. J Lab Clin Med 2001; 138:270-276
22. Bellocq A, Suberville S, Philippe C, et al. Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages: evidence for involvement of nuclear factor-KB activation. J Biol Chem 1998; 273:5086-5092
23. Kellum JA, Song M. Effects of acidosis on LPS-mediated production of inflammatory cytokine and nitric oxide in RAW macrophages [abstract]. Am J Respir Crit Care Med 2002; 165:A545
24. Kellum JA. Metabolic acidosis in the critically ill: lessons from physical chemistry. Kidney Int 1998; 66(suppl):S81-S86
25. Prough DS. Acidosis associated with perioperative saline administration: dilution or delusion? Anesthesiology 2000; 93:1167-1169
26. Wilkes NJ, Woolf R, Mutch M, et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001; 93:811-816
27. Laffey JG, Kavanagh BP. Carbon dioxide and the critically ill: too little of a good thing? Lancet 1999; 354:1283-1286
28. Williams EL, Hildebrand KL, McCormick SA, et al. The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg 1999; 88:999-1003
29. Wilcox CS. Regulation of renal blood flow by plasma chloride. J Clin Invest 1983; 71:726-735
30. Bushinsky DA, Coe FL. Hyperkalemia during acute ammonium chloride acidosis in man [letter]. Nephron 1985; 40:38
31. Augustinsson O, Forslid A. Aldosterone secretion during acute respiratory acidosis and NH4Cl-induced metabolic acidosis in die goat. Acta Physiol Scand 1989; 136:339-345
32. Faucher DJ, Lowe TW, Magness RR, et al. Vasopressin and catecholamine secretion during metabolic acidemia in the ovine fetus. Pediatr Res 1987; 21:38-43
33. Wood CE, Chen HG. Acidemia stimulates ACTH, vasopressin, and heart rate responses in fetal sheep. Am J Physiol 1989; 257(2 pt 2):R344-R349
34. Alkharfy KM, Kellum JA, Matzke G. Unintended immunomodulation: part I; Effect of common clinical conditions on cytokine biosynthesis. Shock 2000; 13:33.3-345
35. Ayala A, Perrin MM, Chaudry IH. Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens. Immunology 1990; 70:33-39