Nuclear Magnetic Resonance (NMR)-Based Drug Metabolite Profiling

Methods in Molecular Biology

Volumn 708, Issue , 2011, Pages 299-319

  Lenz, Eva M ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

1H and 19F NMR spectroscopy; drug metabolites; HPLC; SPE

Indexed keywords

BILE ACID; DRUG; PLASMA PROTEIN;

ANALYSIS; ARTICLE; BLOOD; CHEMISTRY; CLINICAL CHEMISTRY; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; METABOLOME; METABOLOMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRECIPITATION; SOLID PHASE EXTRACTION;

ANALYTIC SAMPLE PREPARATION METHODS; BILE ACIDS AND SALTS; BLOOD PROTEINS; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLINICAL CHEMISTRY TESTS; FREEZE DRYING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; METABOLOMICS; PHARMACEUTICAL PREPARATIONS; SOLID PHASE EXTRACTION;

EID: 79953765261     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61737-985-7_18     Document Type: Chapter

References (11)

1. Braun, S., Kalinowski, H.-O., Berger, S. (1998) 150 and More Basic NMR Experiments, Wiley-VCH Verlag GMBH, 69469 Weinheim, second expanded edition, Germany.
2. Bales, J. R., Nicholson, J. K., Sadler, P. J. (1985) Two-dimensional proton nuclear magnetic resonance “maps” of acetaminophen metabolites in human urine. Clin Chem 31, 757–762.
3. McCormick, A. D., Slamon, D. L., Lenz, E. M., Phillips, P. J., King, C. D., McKillop, D., Roberts, D. W. (2007) In vitro metabolism of a tricyclic alkaloid (M445526) in human liver microsomes and hepatocytes. Xenobiotica 37, 972–985.
4. Moffat, A. C., Jackson, J. V., Moss, M. S., Widdop, B. (eds.) (1986) Clarke’s Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids, and Post-mortem Material, 2nd edn, The Pharmaceutical Press (publi-cations division of The Pharmaceutical Society of Great Britain, 1 Lambeth High Street, London SE1 7JN).
5. Holzgrabe, U., Wawer, I., Diehl, B. (1999) NMR Spectroscopy in Drug Development and Analysis, Wiley-VCH Verlag GmbH, 69469 Weinheim, Germany.
6. Lindon, J. C., Nicholson, J. K., Wilson, I. D. (1995) The development and application of coupled HPLC–NMR spectroscopy. Adv Chromatogr 36, 315–382.
7. Lindon, J. C., Nicholson, J. K., Wilson, I. D. (1996) Direct coupling of chromatographic separations to NMR spectroscopy. Prog Nucl Magn Res 29, 1–49.
8. 19 F HPLC–NMR spectroscopy. J Pharm Biomed Anal 30, 1561– 1574.
9. 14 C]-ZD6126. J Pharm Biomed Anal 43, 1065–1077.
10. Exarchou, V., Fiamegos, Y. C., van Beek, T. A., Nanos, C., Vervoort, J. (2006) Hyphenated chromatographic techniques for the rapid screening and identification of antioxidants in methanolic extracts of pharmaceuti-cally used plants. J Chromatogr A 1112, 293– 302.
11. Martin, P. D., Warwick, M. J., Dane, A. L., Hill, S. J., Giles, P. B., Lenz, E. (2003) Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers. Clin Ther 25, 2822–2834.