HPLC-NMR with severe column overloading: Fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 3, 2007, Pages 1065-1077

  Lenz, E M ^a   D'Souza, R A ^a   Jordan, A C ^a   King, C D ^a   Smith, S M ^a   Phillips, P J ^a   McCormick, A D ^a   Roberts, D W ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Fast track HPLC NMR; Metabolism identification; Vascular targeting agent; ZD6126

Indexed keywords

DRUG METABOLITE; N ACETYLCOLCHINOL PHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; BILE LEVEL; BILIARY EXCRETION; CONTROLLED STUDY; DEMETHYLATION; DOG; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; PRIORITY JOURNAL; RADIOACTIVITY; SEX DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FECES; FEMALE; FREEZE DRYING; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; ORGANOPHOSPHORUS COMPOUNDS; RATS; SEX CHARACTERISTICS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33846581437     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.09.010     Document Type: Article

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