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Volumn 12, Issue 1, 2011, Pages

Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: A review

Author keywords

[No Author keywords available]

Indexed keywords

IK 312532; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE DERIVATIVE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; RESPIRATORY TRACT AGENT; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 79953757270     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-45     Document Type: Review
Times cited : (44)

References (102)
  • 1
    • 0014954352 scopus 로고
    • Polypeptide with broad biological activity: isolation from small intestine
    • Said SI, Mutt V: Polypeptide with broad biological activity: isolation from small intestine. Science 1970, 169:1217-8.
    • (1970) Science , vol.169 , pp. 1217-1218
    • Said, S.I.1    Mutt, V.2
  • 2
    • 0022512057 scopus 로고
    • Vasoactive intestinal peptide
    • Said SI: Vasoactive intestinal peptide. J Endocrinol Invest 1986, 9:191-200.
    • (1986) J Endocrinol Invest , vol.9 , pp. 191-200
    • Said, S.I.1
  • 3
    • 17144442045 scopus 로고
    • Vasoactive polypeptides from normal lung
    • Said SI, Mutt V, Yoshida T, Hara N: Vasoactive polypeptides from normal lung. Chest 1975, 67:44S.
    • (1975) Chest , vol.67 , pp. 44S
    • Said, S.I.1    Mutt, V.2    Yoshida, T.3    Hara, N.4
  • 6
    • 84983078308 scopus 로고    scopus 로고
    • Cardioprotective role of the VIP signaling system
    • Dvoráková MC: Cardioprotective role of the VIP signaling system. Timely Top Med Cardiovasc Dis 2005, 9:E33.
    • (2005) Timely Top Med Cardiovasc Dis , vol.9 , pp. E33
    • Dvoráková, M.C.1
  • 7
    • 0021732482 scopus 로고
    • Vasoactive intestinal peptide relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma
    • Saga T, Said SI: Vasoactive intestinal peptide relaxes isolated strips of human bronchus, pulmonary artery, and lung parenchyma. Trans Assoc Am Physicians 1984, 97:304-10.
    • (1984) Trans Assoc Am Physicians , vol.97 , pp. 304-310
    • Saga, T.1    Said, S.I.2
  • 8
    • 67650689306 scopus 로고    scopus 로고
    • Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease
    • Smalley SG, Barrow PA, Foster N: Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease. Clin Exp Immunol 2009, 157:225-34.
    • (2009) Clin Exp Immunol , vol.157 , pp. 225-234
    • Smalley, S.G.1    Barrow, P.A.2    Foster, N.3
  • 9
    • 77957258386 scopus 로고    scopus 로고
    • Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats
    • Onoue S, Misaka S, Aoki Y, Karaki S, Kuwahara A, Ohide A, Mizumoto T, Yamada S: Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats. Eur J Pharm Sci 2010, 41:508-14.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 508-514
    • Onoue, S.1    Misaka, S.2    Aoki, Y.3    Karaki, S.4    Kuwahara, A.5    Ohide, A.6    Mizumoto, T.7    Yamada, S.8
  • 11
    • 34548415385 scopus 로고    scopus 로고
    • Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD
    • Onoue S, Yamada S, Yajima T: Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD. Peptides 2007, 28:1640-50.
    • (2007) Peptides , vol.28 , pp. 1640-1650
    • Onoue, S.1    Yamada, S.2    Yajima, T.3
  • 12
    • 13444279874 scopus 로고    scopus 로고
    • Pathogenesis of pulmonary arterial hypertension: the need for multiple hits
    • Yuan JX, Rubin LJ: Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation 2005, 111:534-8.
    • (2005) Circulation , vol.111 , pp. 534-538
    • Yuan, J.X.1    Rubin, L.J.2
  • 13
    • 77958458700 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: bridging the gap between efficacy, quality of life, and cost-effectiveness
    • Gandhi R, Baker N, Shek A, Yeh J, Bishop D: Pulmonary arterial hypertension: bridging the gap between efficacy, quality of life, and cost-effectiveness. Formulary 2010, 45:190-199.
    • (2010) Formulary , vol.45 , pp. 190-199
    • Gandhi, R.1    Baker, N.2    Shek, A.3    Yeh, J.4    Bishop, D.5
  • 15
    • 34548222188 scopus 로고    scopus 로고
    • Global burden of COPD: risk factors, prevalence, and future trends
    • Mannino DM, Buist AS: Global burden of COPD: risk factors, prevalence, and future trends. Lancet 2007, 370:765-73.
    • (2007) Lancet , vol.370 , pp. 765-773
    • Mannino, D.M.1    Buist, A.S.2
  • 16
    • 70149113771 scopus 로고    scopus 로고
    • Asthma and COPD: definitions, epidemiology, and treatment guidelines
    • Berger WE, Cline DC: Asthma and COPD: definitions, epidemiology, and treatment guidelines. Postgrad Med 2005, 118:2-8.
    • (2005) Postgrad Med , vol.118 , pp. 2-8
    • Berger, W.E.1    Cline, D.C.2
  • 17
    • 0029876005 scopus 로고    scopus 로고
    • Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide
    • Lundberg JM: Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 1996, 48:113-78.
    • (1996) Pharmacol Rev , vol.48 , pp. 113-178
    • Lundberg, J.M.1
  • 18
    • 0034749277 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide: cardiovascular effects
    • Henning RJ, Sawmiller DR: Vasoactive intestinal peptide: cardiovascular effects. Cardiovasc Res 2001, 49:27-37.
    • (2001) Cardiovasc Res , vol.49 , pp. 27-37
    • Henning, R.J.1    Sawmiller, D.R.2
  • 19
    • 0020525743 scopus 로고
    • Vasoactive intestinal peptide-like immunoreactivity in nerves associated with the cardiovascular system of guinea-pigs
    • Della NG, Papka RE, Furness JB, Costa M: Vasoactive intestinal peptide-like immunoreactivity in nerves associated with the cardiovascular system of guinea-pigs. Neuroscience 1983, 9:605-19.
    • (1983) Neuroscience , vol.9 , pp. 605-619
    • Della, N.G.1    Papka, R.E.2    Furness, J.B.3    Costa, M.4
  • 20
    • 0022535830 scopus 로고
    • Action and localization of vasoactive intestinal peptide in the coronary circulation: evidence for nonadrenergic, noncholinergic coronary regulation
    • Brum JM, Bove AA, Sufan Q, Reilly W, Go VL: Action and localization of vasoactive intestinal peptide in the coronary circulation: evidence for nonadrenergic, noncholinergic coronary regulation. J Am Coll Cardiol 1986, 7:406-13.
    • (1986) J Am Coll Cardiol , vol.7 , pp. 406-413
    • Brum, J.M.1    Bove, A.A.2    Sufan, Q.3    Reilly, W.4    Go, V.L.5
  • 21
    • 0030818847 scopus 로고    scopus 로고
    • Distribution of peptide-containing neurons in the developing rat right atrium, studied using immunofluorescence and confocal laser scanning
    • Slavíková J: Distribution of peptide-containing neurons in the developing rat right atrium, studied using immunofluorescence and confocal laser scanning. Neurochem Res 1997, 22:1013-21.
    • (1997) Neurochem Res , vol.22 , pp. 1013-1021
    • Slavíková, J.1
  • 22
    • 0242584807 scopus 로고    scopus 로고
    • Distribution of vasoactive intestinal polypeptide in the rat heart: effect of guanethidine and capsaicin
    • Kuncová J, Slavíková J, Reischig J: Distribution of vasoactive intestinal polypeptide in the rat heart: effect of guanethidine and capsaicin. Ann Anat 2003, 185:153-61.
    • (2003) Ann Anat , vol.185 , pp. 153-161
    • Kuncová, J.1    Slavíková, J.2    Reischig, J.3
  • 23
    • 0024595094 scopus 로고
    • VIP and autonomic neurotransmission
    • Fahrenkrug J: VIP and autonomic neurotransmission. Pharmacol Ther 1989, 41:515-34.
    • (1989) Pharmacol Ther , vol.41 , pp. 515-534
    • Fahrenkrug, J.1
  • 24
    • 33644814142 scopus 로고    scopus 로고
    • Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors
    • Groneberg DA, Rabe KF, Fischer A: Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors. Eur J Pharmacol 2006, 533:182-94.
    • (2006) Eur J Pharmacol , vol.533 , pp. 182-194
    • Groneberg, D.A.1    Rabe, K.F.2    Fischer, A.3
  • 25
    • 0019787357 scopus 로고
    • Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cat, and human subjects
    • Dey RD, Shannon WA Jr, Said SI: Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cat, and human subjects. Cell Tissue Res 1981, 220:231-8.
    • (1981) Cell Tissue Res , vol.220 , pp. 231-238
    • Dey, R.D.1    Shannon, W.A.2    Said, S.I.3
  • 26
    • 0021221016 scopus 로고
    • Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man
    • Lundberg JM, Fahrenkrug J, Hökfelt T, Martling CR, Larsson O, Tatemoto K, Anggård A: Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man. Peptides 1984, 5:593-606.
    • (1984) Peptides , vol.5 , pp. 593-606
    • Lundberg, J.M.1    Fahrenkrug, J.2    Hökfelt, T.3    Martling, C.R.4    Larsson, O.5    Tatemoto, K.6    Anggård, A.7
  • 27
    • 0021838010 scopus 로고
    • VIP like immunoreactive nerves in human respiratory tract. Light and electron microscopic study
    • Laitinen A, Partanen M, Hervonen A, Pelto-Huikko M, Laitinen LA: VIP like immunoreactive nerves in human respiratory tract. Light and electron microscopic study. Histochemistry 1985, 82:313-9.
    • (1985) Histochemistry , vol.82 , pp. 313-319
    • Laitinen, A.1    Partanen, M.2    Hervonen, A.3    Pelto-Huikko, M.4    Laitinen, L.A.5
  • 28
    • 0030057996 scopus 로고    scopus 로고
    • Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Correlation with neuropeptides
    • Fischer A, Hoffmann B: Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Correlation with neuropeptides. Am J Respir Crit Care Med 1996, 154:209-16.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 209-216
    • Fischer, A.1    Hoffmann, B.2
  • 29
    • 0032507807 scopus 로고    scopus 로고
    • Evidence for an esophageal origin of VIP-IR and NO synthase-IR nerves innervating the guinea pig trachealis: a retrograde neuronal tracing and immunohistochemical analysis
    • Fischer A, Canning BJ, Undem BJ, Kummer W: Evidence for an esophageal origin of VIP-IR and NO synthase-IR nerves innervating the guinea pig trachealis: a retrograde neuronal tracing and immunohistochemical analysis. J Comp Neurol 1998, 394:326-34.
    • (1998) J Comp Neurol , vol.394 , pp. 326-334
    • Fischer, A.1    Canning, B.J.2    Undem, B.J.3    Kummer, W.4
  • 30
    • 0030455524 scopus 로고    scopus 로고
    • Correlation of vasoactive intestinal peptide and nitric oxide synthase with choline acetyltransferase in the airway innervation
    • Fischer A, Canning BJ, Kummer W: Correlation of vasoactive intestinal peptide and nitric oxide synthase with choline acetyltransferase in the airway innervation. Ann N Y Acad Sci 1996, 805:717-22.
    • (1996) Ann N Y Acad Sci , vol.805 , pp. 717-722
    • Fischer, A.1    Canning, B.J.2    Kummer, W.3
  • 31
    • 0024420518 scopus 로고
    • Peptide-containing nerve fibers in the respiratory tract of the ferret
    • Luts A, Sundler F: Peptide-containing nerve fibers in the respiratory tract of the ferret. Cell Tissue Res 1989, 258:259-67.
    • (1989) Cell Tissue Res , vol.258 , pp. 259-267
    • Luts, A.1    Sundler, F.2
  • 32
    • 0018116215 scopus 로고
    • Release of vasoactive intestinal polypeptide in mast cells by histamine liberators
    • Cutz E, Chan W, Track NS, Goth A, Said SI: Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature 1978, 275:661-2.
    • (1978) Nature , vol.275 , pp. 661-662
    • Cutz, E.1    Chan, W.2    Track, N.S.3    Goth, A.4    Said, S.I.5
  • 33
    • 0023567156 scopus 로고
    • Selective localization of vasoactive intestinal peptide and substance P in human eosinophils
    • Aliakbari J, Sreedharan SP, Turck CW, Goetzl EJ: Selective localization of vasoactive intestinal peptide and substance P in human eosinophils. Biochem Biophys Res Commun 1987, 148:1440-5.
    • (1987) Biochem Biophys Res Commun , vol.148 , pp. 1440-1445
    • Aliakbari, J.1    Sreedharan, S.P.2    Turck, C.W.3    Goetzl, E.J.4
  • 34
    • 0028287532 scopus 로고
    • Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide
    • Metwali A, Blum AM, Ferraris L, Klein JS, Fiocchi C, Weinstock JV: Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J Neuroimmunol 1994, 52:69-78.
    • (1994) J Neuroimmunol , vol.52 , pp. 69-78
    • Metwali, A.1    Blum, A.M.2    Ferraris, L.3    Klein, J.S.4    Fiocchi, C.5    Weinstock, J.V.6
  • 35
    • 0018939041 scopus 로고
    • Vasoactive intestinal polypeptide as a biochemical marker for polymorphonuclear leukocytes
    • O'Dorisio MS, O'Dorisio TM, Cataland S, Balcerzak SP: Vasoactive intestinal polypeptide as a biochemical marker for polymorphonuclear leukocytes. J Lab Clin Med 1980, 96:666-72.
    • (1980) J Lab Clin Med , vol.96 , pp. 666-672
    • O'Dorisio, M.S.1    O'Dorisio, T.M.2    Cataland, S.3    Balcerzak, S.P.4
  • 38
    • 0023095226 scopus 로고
    • The plasma vasoactive intestinal peptide (VIP) response to exercise is increased after prolonged strain, sleep and energy deficiency and extinguished by glucose infusion
    • Opstad PK: The plasma vasoactive intestinal peptide (VIP) response to exercise is increased after prolonged strain, sleep and energy deficiency and extinguished by glucose infusion. Peptides 1987, 8:175-8.
    • (1987) Peptides , vol.8 , pp. 175-178
    • Opstad, P.K.1
  • 39
    • 0018123216 scopus 로고
    • Radioimmunoassay of vasoactive intestinal polypeptide in plasma
    • Burhol PG, Lygren I, Waldum HL: Radioimmunoassay of vasoactive intestinal polypeptide in plasma. Scand J Gastroenterol 1978, 13:807-13.
    • (1978) Scand J Gastroenterol , vol.13 , pp. 807-813
    • Burhol, P.G.1    Lygren, I.2    Waldum, H.L.3
  • 40
    • 0015838775 scopus 로고
    • Vasoactive intestinal peptide and watery-diarrhoea syndrome
    • Bloom SR, Polak JM, Pearse AG: Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet 1973, 2:14-6.
    • (1973) Lancet , vol.2 , pp. 14-16
    • Bloom, S.R.1    Polak, J.M.2    Pearse, A.G.3
  • 41
    • 0030272469 scopus 로고    scopus 로고
    • Elevated levels of plasma vasoactive intestinal peptide in human acute myocardial infarction
    • Gyöngyösi M, Németh J, Várkonyi T: Elevated levels of plasma vasoactive intestinal peptide in human acute myocardial infarction. Int J Cardiol 1996, 56:159-61.
    • (1996) Int J Cardiol , vol.56 , pp. 159-161
    • Gyöngyösi, M.1    Németh, J.2    Várkonyi, T.3
  • 42
    • 0018171931 scopus 로고
    • Vasoactive intestinal peptide in man: pharmacokinetics, metabolic and circulatory effects
    • Domschke S, Domschke W, Bloom SR, Mitznegg P, Mitchell SJ, Lux G, Strunz U: Vasoactive intestinal peptide in man: pharmacokinetics, metabolic and circulatory effects. Gut 1978, 19:1049-53.
    • (1978) Gut , vol.19 , pp. 1049-1053
    • Domschke, S.1    Domschke, W.2    Bloom, S.R.3    Mitznegg, P.4    Mitchell, S.J.5    Lux, G.6    Strunz, U.7
  • 43
    • 0019415517 scopus 로고
    • Characteristics of the axonal transport of vasoactive intestinal polypeptide (VIP) in nerves of the cat
    • Lundberg JM, Fahrenkrug J, Brimijoin S: Characteristics of the axonal transport of vasoactive intestinal polypeptide (VIP) in nerves of the cat. Acta Physiol Scand 1981, 112:427-36.
    • (1981) Acta Physiol Scand , vol.112 , pp. 427-436
    • Lundberg, J.M.1    Fahrenkrug, J.2    Brimijoin, S.3
  • 44
    • 0021611651 scopus 로고
    • Vasoactive intestinal polypeptide (VIP): current status
    • Said SI: Vasoactive intestinal polypeptide (VIP): current status. Peptides 1984, 5:143-50.
    • (1984) Peptides , vol.5 , pp. 143-150
    • Said, S.I.1
  • 45
    • 0024537234 scopus 로고
    • Preferential cleavage of amino- and carboxyl-terminal oligopeptides from vasoactive intestinal polypeptide by human recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11)
    • Goetzl EJ, Sreedharan SP, Turck CW, Bridenbaugh R, Malfroy B: Preferential cleavage of amino- and carboxyl-terminal oligopeptides from vasoactive intestinal polypeptide by human recombinant enkephalinase (neutral endopeptidase, EC 3.4.24.11). Biochem Biophys Res Commun 1989, 158:850-4.
    • (1989) Biochem Biophys Res Commun , vol.158 , pp. 850-854
    • Goetzl, E.J.1    Sreedharan, S.P.2    Turck, C.W.3    Bridenbaugh, R.4    Malfroy, B.5
  • 46
    • 0023875638 scopus 로고
    • Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase
    • Caughey GH, Leidig F, Viro NF, Nadel JA: Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J Pharmacol Exp Ther 1988, 244:133-7.
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 133-137
    • Caughey, G.H.1    Leidig, F.2    Viro, N.F.3    Nadel, J.A.4
  • 47
    • 0028235886 scopus 로고
    • Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs
    • Lilly CM, Kobzik L, Hall AE, Drazen JM: Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. J Clin Invest 1994, 93:2667-74.
    • (1994) J Clin Invest , vol.93 , pp. 2667-2674
    • Lilly, C.M.1    Kobzik, L.2    Hall, A.E.3    Drazen, J.M.4
  • 48
    • 0037107385 scopus 로고    scopus 로고
    • Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP
    • Laburthe M, Couvineau A: Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP. Regul Pept 2002, 108:165-173.
    • (2002) Regul Pept , vol.108 , pp. 165-173
    • Laburthe, M.1    Couvineau, A.2
  • 49
    • 0023803473 scopus 로고
    • Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase
    • Francis SH, Noblett BD, Todd BW, Wells JN, Corbin JD: Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol Pharmacol 1988, 34:506-17.
    • (1988) Mol Pharmacol , vol.34 , pp. 506-517
    • Francis, S.H.1    Noblett, B.D.2    Todd, B.W.3    Wells, J.N.4    Corbin, J.D.5
  • 50
    • 0031678491 scopus 로고    scopus 로고
    • Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems
    • Arimura A: Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn J Physiol 1998, 48:301-31.
    • (1998) Jpn J Physiol , vol.48 , pp. 301-331
    • Arimura, A.1
  • 51
    • 0022444841 scopus 로고
    • Visualization of vasoactive intestinal peptide receptors in human and guinea pig lung
    • Carstairs JR, Barnes PJ: Visualization of vasoactive intestinal peptide receptors in human and guinea pig lung. J Pharmacol Exp Ther 1986, 239:249-255.
    • (1986) J Pharmacol Exp Ther , vol.239 , pp. 249-255
    • Carstairs, J.R.1    Barnes, P.J.2
  • 52
    • 38649084996 scopus 로고    scopus 로고
    • Neuropeptides activate human mast cell degranulation and chemokine production
    • Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP: Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 2008, 123:398-410.
    • (2008) Immunology , vol.123 , pp. 398-410
    • Kulka, M.1    Sheen, C.H.2    Tancowny, B.P.3    Grammer, L.C.4    Schleimer, R.P.5
  • 53
    • 4644299546 scopus 로고    scopus 로고
    • Regulation of human polymorphonuclear leukocytes functions by the neuropeptide pituitary adenylate cyclase-activating polypeptide after activation of MAPKs
    • Harfi I, D'Hondt S, Corazza F, Sariban E: Regulation of human polymorphonuclear leukocytes functions by the neuropeptide pituitary adenylate cyclase-activating polypeptide after activation of MAPKs. J Immunol 2004, 173:4154-63.
    • (2004) J Immunol , vol.173 , pp. 4154-4163
    • Harfi, I.1    D'Hondt, S.2    Corazza, F.3    Sariban, E.4
  • 54
    • 0034500696 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide (VIP) receptor type 2 (VPAC2) is the predominant receptor expressed in human thymocytes
    • Lara-Marquez ML, O'Dorisio MS, Karacay B: Vasoactive intestinal peptide (VIP) receptor type 2 (VPAC2) is the predominant receptor expressed in human thymocytes. Ann NY Acad Sci 2000, 921:45-54.
    • (2000) Ann NY Acad Sci , vol.921 , pp. 45-54
    • Lara-Marquez, M.L.1    O'Dorisio, M.S.2    Karacay, B.3
  • 55
    • 0033561657 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation
    • Delgado M, Munoz-Elias EJ, Gomariz RP, Ganea D: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation. J Immunol 1999, 162:4685-96.
    • (1999) J Immunol , vol.162 , pp. 4685-4696
    • Delgado, M.1    Munoz-Elias, E.J.2    Gomariz, R.P.3    Ganea, D.4
  • 56
  • 57
    • 0035923540 scopus 로고    scopus 로고
    • Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide
    • Goetzl EJ, Voice JK, Shen S, Dorsam G, Kong Y, West KM, Morrison CF, Harmar AJ: Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide. Proc Natl Acad Sci USA 2001, 98:13854-13859.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13854-13859
    • Goetzl, E.J.1    Voice, J.K.2    Shen, S.3    Dorsam, G.4    Kong, Y.5    West, K.M.6    Morrison, C.F.7    Harmar, A.J.8
  • 58
    • 0037218515 scopus 로고    scopus 로고
    • Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice
    • Voice JK, Grinninger C, Kong Y, Bangale Y, Paul S, Goetzl EJ: Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice. J Immunol 2003, 170:308-314.
    • (2003) J Immunol , vol.170 , pp. 308-314
    • Voice, J.K.1    Grinninger, C.2    Kong, Y.3    Bangale, Y.4    Paul, S.5    Goetzl, E.J.6
  • 59
    • 0021041715 scopus 로고
    • Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects
    • Morice A, Unwin RJ, Sever PS: Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects. Lancet 1983, 2:1225-7.
    • (1983) Lancet , vol.2 , pp. 1225-1227
    • Morice, A.1    Unwin, R.J.2    Sever, P.S.3
  • 60
    • 0026486361 scopus 로고
    • Beneficial influence of vasoactive intestinal peptide on ventriculovascular coupling in closed-chest dogs
    • Colston JT, Freeman GL: Beneficial influence of vasoactive intestinal peptide on ventriculovascular coupling in closed-chest dogs. Am J Physiol 1992, 263:H1300-5.
    • (1992) Am J Physiol , vol.263 , pp. H1300-H1305
    • Colston, J.T.1    Freeman, G.L.2
  • 61
    • 0024447233 scopus 로고
    • Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles
    • Rigel DF, Grupp IL, Balasubramaniam A, Grupp G: Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles. Am J Physiol 1989, 257:H1082-7.
    • (1989) Am J Physiol , vol.257 , pp. H1082-H1087
    • Rigel, D.F.1    Grupp, I.L.2    Balasubramaniam, A.3    Grupp, G.4
  • 62
    • 0025689726 scopus 로고
    • Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs
    • Rigel DF, Lathrop DA: Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs. Circ Res 1990, 67:1323-33.
    • (1990) Circ Res , vol.67 , pp. 1323-1333
    • Rigel, D.F.1    Lathrop, D.A.2
  • 63
    • 0026666499 scopus 로고
    • Vagal stimulation during muscarinic and beta-adrenergic blockade increases atrial contractility and heart rate
    • Henning RJ: Vagal stimulation during muscarinic and beta-adrenergic blockade increases atrial contractility and heart rate. J Auton Nerv Syst 1992, 40:121-9.
    • (1992) J Auton Nerv Syst , vol.40 , pp. 121-129
    • Henning, R.J.1
  • 64
    • 0030296937 scopus 로고    scopus 로고
    • Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate
    • Henning RJ, Feliciano L, Coers CM: Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate. Cardiovasc Res 1996, 32:846-53.
    • (1996) Cardiovasc Res , vol.32 , pp. 846-853
    • Henning, R.J.1    Feliciano, L.2    Coers, C.M.3
  • 66
    • 0034780321 scopus 로고    scopus 로고
    • Vasoactive intestinal polypeptide as mediator of asthma
    • Groneberg DA, Springer J, Fischer A: Vasoactive intestinal polypeptide as mediator of asthma. Pulm Pharmacol Ther 2001, 14:391-401.
    • (2001) Pulm Pharmacol Ther , vol.14 , pp. 391-401
    • Groneberg, D.A.1    Springer, J.2    Fischer, A.3
  • 67
    • 0020900405 scopus 로고
    • Vasoactive intestinal peptide counteracts leukotriene D4-induced contractions of guinea pig trachea, lung, and pulmonary artery
    • Hamasaki Y, Saga T, Mojarad M, Said SI: Vasoactive intestinal peptide counteracts leukotriene D4-induced contractions of guinea pig trachea, lung, and pulmonary artery. Trans Assoc Am Physicians 1983, 96:406-11.
    • (1983) Trans Assoc Am Physicians , vol.96 , pp. 406-411
    • Hamasaki, Y.1    Saga, T.2    Mojarad, M.3    Said, S.I.4
  • 68
    • 0022976171 scopus 로고
    • VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways
    • Palmer JB, Cuss FM, Barnes PJ: VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways. J Appl Physiol 1986, 61:1322-8.
    • (1986) J Appl Physiol , vol.61 , pp. 1322-1328
    • Palmer, J.B.1    Cuss, F.M.2    Barnes, P.J.3
  • 69
    • 0034998194 scopus 로고    scopus 로고
    • Expression and distribution of vasoactive intestinal polypeptide receptor VPAC(2) mRNA in human airways
    • Groneberg DA, Hartmann P, Dinh QT, Fischer A: Expression and distribution of vasoactive intestinal polypeptide receptor VPAC(2) mRNA in human airways. Lab Invest 2001, 81:749-55.
    • (2001) Lab Invest , vol.81 , pp. 749-755
    • Groneberg, D.A.1    Hartmann, P.2    Dinh, Q.T.3    Fischer, A.4
  • 70
    • 0019838242 scopus 로고
    • Inhibition by vasoactive intestinal peptide of glycoconjugate and lysozyme secretion by human airways in vitro
    • Coles SJ, Said SI, Reid LM: Inhibition by vasoactive intestinal peptide of glycoconjugate and lysozyme secretion by human airways in vitro. Am Rev Respir Dis 1981, 124:531-6.
    • (1981) Am Rev Respir Dis , vol.124 , pp. 531-536
    • Coles, S.J.1    Said, S.I.2    Reid, L.M.3
  • 72
    • 0023277474 scopus 로고
    • The effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea
    • Webber SE, Widdicombe JG: The effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea. Br J Pharmacol 1987, 91:139-48.
    • (1987) Br J Pharmacol , vol.91 , pp. 139-148
    • Webber, S.E.1    Widdicombe, J.G.2
  • 73
    • 0024273056 scopus 로고
    • VIP augments cholinergic-induced glycoconjugate secretion in tracheal submucosal glands
    • Shimura S, Sasaki T, Ikeda K, Sasaki H, Takishima T: VIP augments cholinergic-induced glycoconjugate secretion in tracheal submucosal glands. J Appl Physiol 1988, 65:2537-44.
    • (1988) J Appl Physiol , vol.65 , pp. 2537-2544
    • Shimura, S.1    Sasaki, T.2    Ikeda, K.3    Sasaki, H.4    Takishima, T.5
  • 74
    • 0036166975 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases
    • Delgado M, Abad C, Martinez C, Juarranz MG, Arranz A, Gomariz RP, Leceta J: Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases. J Mol Med 2002, 80:16-24.
    • (2002) J Mol Med , vol.80 , pp. 16-24
    • Delgado, M.1    Abad, C.2    Martinez, C.3    Juarranz, M.G.4    Arranz, A.5    Gomariz, R.P.6    Leceta, J.7
  • 75
    • 0020621379 scopus 로고
    • Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung
    • Undem BJ, Dick EC, Buckner CK: Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung. Eur J Pharmacol 1983, 88:247-50.
    • (1983) Eur J Pharmacol , vol.88 , pp. 247-250
    • Undem, B.J.1    Dick, E.C.2    Buckner, C.K.3
  • 76
    • 0024311965 scopus 로고
    • Identification of high affinity receptors for vasoactive intestinal peptide on human lymphocytes of B cell lineage
    • O'Dorisio MS, Shannon BT, Fleshman DJ, Campolito LB: Identification of high affinity receptors for vasoactive intestinal peptide on human lymphocytes of B cell lineage. J Immunol 1989, 142:3533-6.
    • (1989) J Immunol , vol.142 , pp. 3533-3536
    • O'Dorisio, M.S.1    Shannon, B.T.2    Fleshman, D.J.3    Campolito, L.B.4
  • 77
    • 0025471244 scopus 로고
    • Vasoactive intestinal peptide prevents lung injury due to xanthine/xanthine oxidase
    • Berisha H, Foda H, Sakakibara H, Trotz M, Pakbaz H, Said SI: Vasoactive intestinal peptide prevents lung injury due to xanthine/xanthine oxidase. Am J Physiol 1990, 259:L151-5.
    • (1990) Am J Physiol , vol.259 , pp. L151-L155
    • Berisha, H.1    Foda, H.2    Sakakibara, H.3    Trotz, M.4    Pakbaz, H.5    Said, S.I.6
  • 78
    • 0025164440 scopus 로고
    • Vasoactive intestinal peptide, a singlet oxygen quencher
    • Misra BR, Misra HP: Vasoactive intestinal peptide, a singlet oxygen quencher. J Biol Chem 1990, 265:15371-4.
    • (1990) J Biol Chem , vol.265 , pp. 15371-15374
    • Misra, B.R.1    Misra, H.P.2
  • 79
    • 0034505106 scopus 로고    scopus 로고
    • Receptors and transcriptional factors involved in the anti-inflammatory activity of VIP and PACAP
    • Leceta J, Gomariz RP, Martinez C, Abad C, Ganea D, Delgado M: Receptors and transcriptional factors involved in the anti-inflammatory activity of VIP and PACAP. Ann N Y Acad Sci 2000, 921:92-102.
    • (2000) Ann N Y Acad Sci , vol.921 , pp. 92-102
    • Leceta, J.1    Gomariz, R.P.2    Martinez, C.3    Abad, C.4    Ganea, D.5    Delgado, M.6
  • 80
    • 0031730550 scopus 로고    scopus 로고
    • Signalling in neuropeptide-induced migration of human eosinophils
    • Dunzendorfer S, Meierhofer C, Wiedermann CJ: Signalling in neuropeptide-induced migration of human eosinophils. J Leukoc Biol 1998, 64:828-34.
    • (1998) J Leukoc Biol , vol.64 , pp. 828-834
    • Dunzendorfer, S.1    Meierhofer, C.2    Wiedermann, C.J.3
  • 82
    • 0038739348 scopus 로고    scopus 로고
    • VIP: a very important peptide in T helper differentiation
    • Delgado M: VIP: a very important peptide in T helper differentiation. Trends Immunol 2003,24(5):221-4.
    • (2003) Trends Immunol , vol.24 , Issue.5 , pp. 221-224
    • Delgado, M.1
  • 83
    • 0036118880 scopus 로고    scopus 로고
    • The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
    • Gunaydin S, Imai Y, Takanashi Y, Seo K, Hagino I, Chang D, Shinoka T: The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine. Cardiovasc Surg 2002, 10:138-45.
    • (2002) Cardiovasc Surg , vol.10 , pp. 138-145
    • Gunaydin, S.1    Imai, Y.2    Takanashi, Y.3    Seo, K.4    Hagino, I.5    Chang, D.6    Shinoka, T.7
  • 84
    • 56649122070 scopus 로고    scopus 로고
    • The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
    • Said SI: The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation. Ann N Y Acad Sci 2008, 1144:148-53.
    • (2008) Ann N Y Acad Sci , vol.1144 , pp. 148-153
    • Said, S.I.1
  • 88
    • 0042231982 scopus 로고    scopus 로고
    • The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom
    • Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB: The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003, 124:474-81.
    • (2003) Chest , vol.124 , pp. 474-481
    • Soriano, J.B.1    Davis, K.J.2    Coleman, B.3    Visick, G.4    Mannino, D.5    Pride, N.B.6
  • 89
    • 79952750651 scopus 로고    scopus 로고
    • Pulmonary Hypertension in COPD: Pathophysiology and Therapeutic Targets
    • Zakynthinos E, Daniil Z, Papanikolaou G, Makris D: Pulmonary Hypertension in COPD: Pathophysiology and Therapeutic Targets. Curr Drug Targets 2011, 12:501-13.
    • (2011) Curr Drug Targets , vol.12 , pp. 501-513
    • Zakynthinos, E.1    Daniil, Z.2    Papanikolaou, G.3    Makris, D.4
  • 90
    • 77951154552 scopus 로고    scopus 로고
    • Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?
    • Said SI, Hamidi SA, Gonzalez Bosc L: Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis? Eur Respir J 2010, 35:730-4.
    • (2010) Eur Respir J , vol.35 , pp. 730-734
    • Said, S.I.1    Hamidi, S.A.2    Gonzalez Bosc, L.3
  • 92
    • 0030934358 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pulmonary vascular remodeling
    • Stenmark KR, Mecham RP: Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 1997, 59:89-144.
    • (1997) Annu Rev Physiol , vol.59 , pp. 89-144
    • Stenmark, K.R.1    Mecham, R.P.2
  • 93
    • 14944346763 scopus 로고    scopus 로고
    • Airway remodeling in asthma: therapeutic implications of mechanisms
    • Homer RJ, Elias JA: Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda) 2005, 20:28-35.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 28-35
    • Homer, R.J.1    Elias, J.A.2
  • 95
    • 2342520708 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells
    • Onoue S, Ohmori Y, Endo K, Yamada S, Kimura R, Yajima T: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells. Eur JBiochem 2004, 271:1757-67.
    • (2004) Eur JBiochem , vol.271 , pp. 1757-1767
    • Onoue, S.1    Ohmori, Y.2    Endo, K.3    Yamada, S.4    Kimura, R.5    Yajima, T.6
  • 96
    • 33750931393 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide enhances wound healing and proliferation of human bronchial epithelial cells
    • Guan CX, Zhang M, Qin XQ, Cui YR, Luo ZQ, Bai HB, Fang X: Vasoactive intestinal peptide enhances wound healing and proliferation of human bronchial epithelial cells. Peptides 2006, 27:3107-14.
    • (2006) Peptides , vol.27 , pp. 3107-3114
    • Guan, C.X.1    Zhang, M.2    Qin, X.Q.3    Cui, Y.R.4    Luo, Z.Q.5    Bai, H.B.6    Fang, X.7
  • 97
    • 73049092065 scopus 로고    scopus 로고
    • Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: anti-inflammatory effect in experimental asthmatic rats
    • Misaka S, Aoki Y, Karaki S, Kuwahara A, Mizumoto T, Onoue S, Yamada S: Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: anti-inflammatory effect in experimental asthmatic rats. Peptides 2010, 31:72-8.
    • (2010) Peptides , vol.31 , pp. 72-78
    • Misaka, S.1    Aoki, Y.2    Karaki, S.3    Kuwahara, A.4    Mizumoto, T.5    Onoue, S.6    Yamada, S.7
  • 98
    • 78751646325 scopus 로고    scopus 로고
    • Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis
    • Misaka S, Sato H, Aoki Y, Mizumoto T, Onoue S, Yamada S: Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis. Peptides 2011, 32:401-7.
    • (2011) Peptides , vol.32 , pp. 401-407
    • Misaka, S.1    Sato, H.2    Aoki, Y.3    Mizumoto, T.4    Onoue, S.5    Yamada, S.6
  • 99
    • 23144449186 scopus 로고    scopus 로고
    • Human VIP-alpha: an emerging biologic response modifier to treat primary pulmonary hypertension
    • Rubinstein I: Human VIP-alpha: an emerging biologic response modifier to treat primary pulmonary hypertension. Expert Rev Cardiovasc Ther 2005, 3:565-9.
    • (2005) Expert Rev Cardiovasc Ther , vol.3 , pp. 565-569
    • Rubinstein, I.1


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