Relative lack of T regulatory cells in adult eosinophilic esophagitis - No normalization after corticosteroid therapy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 5, 2011, Pages 705-707

  Stuck, M C ^a   Straumann, A ^a   Simon, H U ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

allergy; eosinophilic esophagitis; Foxp3; T cells; T regulatory cells

Indexed keywords

BUDESONIDE; CD3 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CONFOCAL MICROSCOPY; CORTICOSTEROID THERAPY; DRUG EFFICACY; EOSINOPHILIC ESOPHAGITIS; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TREATMENT RESPONSE;

ADRENAL CORTEX HORMONES; ADULT; BUDESONIDE; CASE-CONTROL STUDIES; EOSINOPHILIC ESOPHAGITIS; HUMANS; LYMPHOCYTE COUNT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; T-LYMPHOCYTES, REGULATORY;

EID: 79953752996     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02525.x     Document Type: Article

References (6)

1. Furuta GT, Liacouras C, Collins MH, Gupta SK, Justinich C, Putnam PE, et al., Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342-1363.
2. Feuerer M, Hill JA, Mathis D, Benoist C,. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009; 10: 689-695.
3. Straumann A, Conus S, Degen L, Felder S, Kummer M, Engel S, et al., Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010; 139: 1526-1537.
4. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU,. Idiopathic eosinophilic esophagitis is associated with a Th2-type allergic inflammatory response. J Allergy Clin Immunol 2001; 108: 954-961. (Pubitemid 33151548)
5. Fuentebella J, Patel A, Nguyen T, Sanjanwala B, Berquist W, Kerner JA, et al., Increased number of regulatory T cells in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2010; 51: 283-289.
6. Ryanna K, Stratigou V, Safinia N, Hawrylowicz C,. Regulatory T cells in bronchial asthma. Allergy 2009; 64: 335-347.