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Volumn 708, Issue , 2011, Pages 173-190

High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS)-Based Drug Metabolite Profiling

Author keywords

liquid chromatography; Mass spectrometry; metabolite identification; metabolite profiling

Indexed keywords

PLASMA PROTEIN; XENOBIOTIC AGENT;

EID: 79953751037     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61737-985-7_10     Document Type: Chapter
Times cited : (21)

References (13)
  • 1
    • 84889367186 scopus 로고    scopus 로고
    • Application of liquid chromatography/mass spectrometry for metabolite identification
    • Zhang, D., Zhu, M., Humphreys, W. G., eds.), Wiley, New Jersey
    • Ma, S., Chowdhury, S. K. (2008) Application of liquid chromatography/mass spectrometry for metabolite identification, in (Zhang, D., Zhu, M., Humphreys, W. G., eds.), Drug Metabolism in Drug Design and Development, pp. 319–368. Wiley, New Jersey.
    • (2008) Drug Metabolism in Drug Design and Development , pp. 319-368
    • Ma, S.1    Chowdhury, S.K.2
  • 2
    • 23944461321 scopus 로고    scopus 로고
    • Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS
    • Johnson, K. A., Plumb, R. (2005) Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS. J Pharm Biomed Anal 39, 805–810.
    • (2005) J Pharm Biomed Anal , vol.39 , pp. 805-810
    • Johnson, K.A.1    Plumb, R.2
  • 3
    • 84926398243 scopus 로고    scopus 로고
    • Applications of liquid radiochro-matography techniques in drug metabolism studies
    • Zhang, D., Zhu, M., Humphreys, W. G., Wiley, New Jersey
    • Zhu, M., Zhao, W., Humphreys, W. G. (2008) Applications of liquid radiochro-matography techniques in drug metabolism studies, in (Zhang, D., Zhu, M., Humphreys, W. G., eds), Drug Metabolism in Drug Design and Development, pp. 319–368. Wiley, New Jersey.
    • (2008) Drug Metabolism in Drug Design and Development , pp. 319-368
    • Zhu, M.1    Zhao, W.2    Humphreys, W.G.3
  • 5
    • 33846019976 scopus 로고    scopus 로고
    • Topcount coupled to ultra-performance liquid chromatography for the profiling of radiolabeled drug metabolites in complex biological samples
    • Dear, G. J., Patel, N., Kelly, P. J., Webber, L., Yung, M. J. (2006) Topcount coupled to ultra-performance liquid chromatography for the profiling of radiolabeled drug metabolites in complex biological samples. J Chromatogr B 884, 96–103.
    • (2006) J Chromatogr B , vol.884 , pp. 96-103
    • Dear, G.J.1    Patel, N.2    Kelly, P.J.3    Webber, L.4    Yung, M.J.5
  • 6
    • 0030156789 scopus 로고    scopus 로고
    • Direct coupling of chromatographic separations to NMR spectroscopy
    • Lindon, J. C., Nicholson, J. K., Wilson, I. D. (1996) Direct coupling of chromatographic separations to NMR spectroscopy. Prog Nucl Magn Res 29, 1–49.
    • (1996) Prog Nucl Magn Res , vol.29 , pp. 1-49
    • Lindon, J.C.1    Nicholson, J.K.2    Wilson, I.D.3
  • 9
    • 0842327199 scopus 로고    scopus 로고
    • Integration of knowledge-based metabolic predici-tions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: Application to studies on the biotransformation of indinvar
    • Anari, M. R., Sanchez, R. I., Bakhtiar, R., Franklin, R. B., Baillie, T. A. (2004) Integration of knowledge-based metabolic predici-tions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinvar. Anal Chem 76, 823–832.
    • (2004) Anal Chem , vol.76 , pp. 823-832
    • Anari, M.R.1    Sanchez, R.I.2    Bakhtiar, R.3    Franklin, R.B.4    Baillie, T.A.5
  • 10
  • 11
    • 85139174779 scopus 로고    scopus 로고
    • Molnar-Institut für Angewandte Chromatographie, Berlin, Germany
    • R○ (2000) Chromatography Optimisation Software, version 3.0.09, Molnar-Institut für Angewandte Chromatographie, Berlin, Germany.
    • (2000) Chromatography Optimisation Software, Version 3.0 , pp. 09
  • 13
    • 70349669455 scopus 로고    scopus 로고
    • Application of high temperature LC to the separation of AZD5438 (4-(1-isopropyl-2-menythyl-1 H-imidazol-5-yl)-N-4(methylsulphonyl))phenyl]pyrimidin-2-amine) and its metabolites: Comparison of UPLC and HTLC
    • Shillingford, S., Bishop, L., Smith, C. J., Payne, R., Wilson, I. D., Edge, A. M. (2009) Application of high temperature LC to the separation of AZD5438 (4-(1-isopropyl-2-menythyl-1 H-imidazol-5-yl)-N-4(methylsulphonyl))phenyl]pyrimidin-2-amine) and its metabolites: comparison of UPLC and HTLC. Chromatographia 70, 37–44.
    • (2009) Chromatographia , vol.70 , pp. 37-44
    • Shillingford, S.1    Bishop, L.2    Smith, C.J.3    Payne, R.4    Wilson, I.D.5    Edge, A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.