Genome analysis of selected foodborne pathogens for identification of drug targets

Current Trends in Biotechnology and Pharmacy

Volumn 5, Issue 2, 2011, Pages 1134-1148

  Shakyawar, Sushil Kumar ^a   Goyal, Arun ^a   Dubey, Vikash Kumar ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

Author keywords

Antimicrobial drugs; Drug targets; Essential proteins

Indexed keywords

4 AMINOBENZOATE SYNTHASE; ABC TRANSPORTER; ALANINE RACEMASE; ATP DEPENDENT DNA HELICASE PCRA; BACTERIAL PROTEIN; CHROMOSOMAL REPLICATION INITIATION PROTEIN; DNA DIRECTED DNA POLYMERASE BETA; FORMATE ACETYLTRANSFERASE; GENE PRODUCT; GLUTAMATE CYSTEINE LIGASE; GUANINE HYPOXANTHINE PERMEASE; HYPOTHETICAL PROTEIN; METHYL ACCEPTING CHEMOTAXIS PROTEIN; OLIGOPEPTIDE ABC TRANSPORT SYSTEM SUBSTRATE BINDING PROTEIN; PHOSPHOGLYCERATE KINASE; PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ADENOSINE TRIPHOSPHATASE SUBUNIT; PHOSPHOTRANSFERASE; PROBABLE THIOREDOXIN REDUCTASE; PROLINE DEHYDROGENASE; PROTEIN HISTIDINE KINASE; PUTATIVE GLUTAMATE SYNTHASE; RECF PROTEIN; SODIUM PROTON EXCHANGE NHAC PROTEIN; UDP N ACETYLMURAMOYL TRIPEPTIDE ALANYL ALANINE LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS CEREUS; BACTERIAL GENOME; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BACTERIUM DETECTION; COMPUTER MODEL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG RESEARCH; DRUG TARGETING; FOOD CONTAMINATION; FOOD POISONING; FOOD SAFETY; GENE FREQUENCY; GENE IDENTIFICATION; GENOME ANALYSIS; LISTERIA MONOCYTOGENES; NONHUMAN; PHARMACOGENOMICS; PROTEIN FUNCTION;

BACILLUS CEREUS; BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES;

EID: 79953736437     PISSN: 09738916     EISSN: 22307303     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Kaminski, N. (2000). Bioinformatics. A user's perspective. Am. J. Respir. Cell Mol. Biol., 23: 705-711.
2. Sakharkar, K.R., Sakharkar, M.K. and Chow, V.T. (2004). A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol., 4: 355-360.
3. Allsop, A.E. (1998). New antibiotic discovery, novel screens, novel targets and impact of microbial genomics. Curr. Opin. Microbiol., 1: 530-534.
4. Sakharkar, K.R., Sakharkar, M.K. and Chow, V.T.K. (2004) A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol., 4: 0028.
5. Judson, N. and Mekalanos, J.J. (2000). TnAraOut, A transposon-based approach to identify and characterize essential bacterial genes. Nat. Biotechnol., 18: 740-745.
6. Frtiz, B. and Raczniak, G.A. (2002) Bacterial genomics: potential for antimicrobial drug discovery. BioDrugs., 16:331.
7. Miesel, L., Greene, J. and Black, T.A. (2003). Genetic strategies for antibacterial drug discovery. Nat. Rev. Genet., 4: 442-456.
8. Rosamond, J. and Allsop, A. (2000). Harnessing the Power of the Genome in the Search for New Antibiotics. Science, 5460: 1973-1976
9. Ramaswamy, V., Cresence, V.M., Rejitha, J.S., Lekshmi, M.U., Dharsana, K.S., Prasad, S.P. and Vijila, H.M. (2007). Listeria-review of epidemiology and pathogenesis. J Microbiol Immunol Infect., 40: 4-13.
10. Li, W., Jaroszewski, L. and Godzik, A. (2001). Clustering of highly homologous sequences to reduce the size of large protein databases. Bioinformatics, 17: 282-283.
11. Suthar, N., Goyal, A. and Dubey, V.K. (2009). Identification of potential drug targets of Leishmania infantum by in-silico genome analysis. Letters in Drug Design and Discovery, 6: 620-622.
12. Salihu, M. D., Junaidu, A. U., Manga, S. B., Gulumbe, M. L., Magaji, A. A., Ahmed A., Adamu, A.Y., Shittu, A. and Balarabe, I. (2008). Occurrence of Listeria monocytogenes in smoked fish in Sokoto, Nigeria. African Journal of Biotechnology, 7: 3082-3084.
13. Pentecost, M., Kumaran, J., Ghosh, P. and Amieva, M.R. (2010) Listeria monocytogenes Internalin B Activates Junctional Endocytosis to Accelerate Intestinal Invasion. PLoS Pathogens, DOI: 10.1371/journal.ppat.1000900
14. Shakyawar, S.K., Goyal, A. and Dubey, V.K. (2011). Database of in silico Predicted Potential Drug Target Proteins in Common Bacterial Human Pathogens. American Journal of Drug Discovery and Development, 1: 70-74.
15. Van der Veen, S. and Abee, T. (2011). Contribution of Listeria monocytogenes RecA to acid and bile survival and invasion of human intestinal Caco-2 cells. Int J Med Microbiol http://dx.doi.org/10.1016/j.ijmm.2010.11.006