Different characteristics of human herpesvirus 6 encephalitis between primary infection and viral reactivation

Journal of Clinical Virology

Volumn 51, Issue 1, 2011, Pages 12-19

  Kawamura, Yoshiki ^a   Sugata, Ken ^a   Ihira, Masaru ^b   Mihara, Takateru ^a   Mutoh, Tatsuro ^a   Asano, Yoshizo ^a   Yoshikawa, Tetsushi ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Cerebrospinal fluid; Cytokine; Encephalitis; Human herpesvirus 6; Post transplant encephalitis; Primary infection

Indexed keywords

BIOLOGICAL MARKER; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; TISSUE INHIBITOR OF METALLOPROTEINASE 1; VIRUS DNA;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COPY NUMBER VARIATION; ENCEPHALITIS; FEBRILE CONVULSION; FEMALE; HUMAN; HUMAN HERPESVIRUS 6; MALE; PATHOGENESIS; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; VIRUS REACTIVATION; VIRUS VIRULENCE;

ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DNA, VIRAL; ENCEPHALITIS, VIRAL; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; INTERLEUKINS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECURRENCE; ROSEOLOVIRUS INFECTIONS; SEIZURES, FEBRILE; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSPLANTATION; VIRUS ACTIVATION;

EID: 79953732311     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2011.02.002     Document Type: Article

References (35)

1. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988, 1:1065-1067.
2. Asano Y., Yoshikawa T., Suga S., Yazaki T., Hata T., Nagai T., et al. Viremia and neutralizing antibody response in infants with exanthem subitum. J Pediatr 1989, 114:535-539.
3. Yoshikawa T., Ohashi M., Miyake F., Fujita A., Usui C., Sugata K., et al. Exanthem subitum-associated encephalitis: nationwide survey in Japan. Pediatr Neurol 2009, 41:353-358.
4. Singh N., Paterson D.L. Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus. Transplantation 2000, 69:2474-2479.
5. Zerr D.M., Gooley T.A., Yeung L., Huang M.L., Carpenter P., Wade J.C., et al. Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients. Clin Infect Dis 2001, 33:763-771.
6. Ogata M., Kikuchi H., Satou T., Kawano R., Ikewaki J., Kohno K., et al. Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. J Infect Dis 2006, 193:68-79.
7. Chamberlain M.C., Chowdhary S. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology 2008, 70:491-492. [author reply 492-3].
8. Seeley W.W., Marty F.M., Holmes T.M., Upchurch K., Soiffer R.J., Antin J.H., et al. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology 2007, 69:156-165.
9. Fujino Y., Nakajima M., Inoue H., Kusuhara T., Yamada T. Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome. Ann Neurol 2002, 51:771-774.
10. Descamps V., Collot S., Houhou N., Ranger-Rogez S. Human herpesvirus-6 encephalitis associated with hypersensitivity syndrome. Ann Neurol 2003, 53:280.
11. Del Borgo C., Zaniratti S., Minosse C., Vetica A., Bellini A., Soscia F., et al. A case of acute polyradiculoneuropathy, drug-induced hypersensitivity, and HHV-6 infection. Neurology 2009, 72:935-936.
12. Yoshikawa T., Nakashima T., Suga S., Asano Y., Yazaki T., Kimura H., et al. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Pediatrics 1992, 89:888-890.
13. Suga S., Yoshikawa T., Asano Y., Kozawa T., Nakashima T., Kobayashi I., et al. Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. Ann Neurol 1993, 33:597-603.
14. Tavakoli N.P., Nattanmai S., Hull R., Fusco H., Dzigua L., Wang H., et al. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol 2007, 45:3972-3978.
15. Kondo K., Nagafuji H., Hata A., Tomomori C., Yamanishi K. Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Infect Dis 1993, 167:1197-1200.
16. Yao K., Akyani N., Donati D., Sengamalay N., Fotheringham J., Ghedin E., et al. Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis. J Clin Virol 2006, 37 Suppl. 1:S57-S62.
17. Fotheringham J., Donati D., Akhyani N., Fogdell-Hahn A., Vortmeyer A., Heiss J.D., et al. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med 2007, 4:e180.
18. Yoshikawa T., Asano Y., Akimoto S., Ozaki T., Iwasaki T., Kurata T., et al. Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis. J Med Virol 2002, 66:497-505.
19. Tanaka N., Kimura H., Hoshino Y., Kato K., Yoshikawa T., Asano Y., et al. Monitoring four herpesviruses in unrelated cord blood transplantation. Bone Marrow Transplant 2000, 26:1193-1197.
20. Zerr D.M., Gupta D., Huang M.L., Carter R., Corey L. Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002, 34:309-317.
21. Pohlmann C., Schetelig J., Reuner U., Bornhauser M., Illmer T., Kiani A., et al. Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient. Clin Infect Dis 2007, 44:e118-e120.
22. Ichiyama T., Ito Y., Kubota M., Yamazaki T., Nakamura K., Furukawa S. Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. Brain Dev 2009, 31:731-738.
23. Kamei S., Taira N., Ishihara M., Sekizawa T., Morita A., Miki K., et al. Prognostic value of cerebrospinal fluid cytokine changes in herpes simplex virus encephalitis. Cytokine 2009, 46:187-193.
24. Winter P.M., Dung N.M., Loan H.T., Kneen R., Wills B., Thu le T., Thu le T, et al. Proinflammatory cytokines and chemokines in humans with Japanese encephalitis. J Infect Dis 2004, 190:1618-1626.
25. Ishiguro A., Suzuki Y., Inaba Y., Fukushima K., Komiyama A., Koeffler H.P., et al. The production of IL-8 in cerebrospinal fluid in aseptic meningitis of children. Clin Exp Immunol 1997, 109:426-430.
26. Lopez-Cortes L.F., Cruz-Ruiz M., Gomez-Mateos J., Viciana-Fernandez P., Martinez-Marcos F.J., Pachon J. Interleukin-8 in cerebrospinal fluid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor. J Infect Dis 1995, 172:581-584.
27. Larsen C.G., Anderson A.O., Appella E., Oppenheim J.J., Matsushima K. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 1989, 243:1464-1466.
28. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., Yoshida M., Ding H.A., Gimbrone M.A., et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999, 398:718-723.
29. Asahi M., Wang X., Mori T., Sumii T., Jung J.C., Moskowitz M.A., et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 2001, 21:7724-7732.
30. Lo E.H., Wang X., Cuzner M.L. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res 2002, 69:1-9.
31. Ichiyama T., Morishima T., Kajimoto M., Matsushige T., Matsubara T., Furukawa S. Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy. Pediatr Infect Dis J 2007, 26:542-544.
32. Yan C., Boyd D.D. Regulation of matrix metalloproteinase gene expression. J Cell Physiol 2007, 211:19-26.
33. Challoner P.B., Smith K.T., Parker J.D., MacLeod D.L., Coulter S.N., Rose T.M., et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 1995, 92:7440-7444.
34. Cermelli C., Berti R., Soldan S.S., Mayne M., D'Ambrosia J.M., Ludwin S.K., et al. High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection. J Infect Dis 2003, 187:1377-1387.
35. Yao K., Gagnon S., Akhyani N., Williams E., Fotheringham J., Frohman E., et al. Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PLoS One 2008, 3:e2028.