A randomized, single-blind, substitution study of oros methylphenidate (concerta) in ADHD adults receiving immediate release methylphenidate

Journal of Attention Disorders

Volumn 15, Issue 4, 2011, Pages 286-294

  Spencer, Thomas J ^a   Mick, Eric ^a   Surman, Craig B H ^a   Hammerness, Paul ^a   Doyle, Robert ^a   Aleardi, Megan ^a   Kotarski, Meghan ^a   Williams, Courtney G ^a   Biederman, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

ADHD; adult; clinical trial; methylphenidate

Indexed keywords

METHYLPHENIDATE;

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DRUG ADMINISTRATION; DRUG SUBSTITUTION; FEMALE; HOSPITALIZATION; HUMAN; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; DRUG SUBSTITUTION; FEMALE; HUMANS; INTENTION TO TREAT ANALYSIS; MALE; METHYLPHENIDATE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 79953726757     PISSN: 10870547     EISSN: 15571246     Source Type: Journal    
DOI: 10.1177/1087054710367880     Document Type: Article

References (18)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Biederman, J. (2006). Comparative and acute efficacy and tolerability of OROS and iommmediate release formulations of methylphenidate in the treatment of adults with attention deficit hyperactivity disorder. Biological Psychiatry, 59(Suppl. 8), 115S.
3. Biederman, J., Faraone, S.V., Spencer, T., Wilens, T., Norman, D., Lapey, K.A.,.Doyle, A. (1993). Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. American Journal of Psychiatry, 150, 1792-1798.
4. Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Harpold, T.,.Spencer, T. (2006). A randomized, placebo-controlled trial of OROS-methylphenidate in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry, 59, 829-835.
5. First, M.B., Spitzer, R.L., Gibbon, M., & Williams, J.B.W. (1997). Structured clinical interview for DSM-IV Axis I disorders-clinician version (SCID-CV). Washington, DC: American Psychiatric Press.
6. Greenhill, L., Beyer D.H., Finkleson, J., Shaffer, D., Biederman, J., Conners, C.K.,.Volkow, N. (2002). Guidelines and algorithms for the use of methylphenidate in children with attention-deficit/hyperactivity disorder. Journal of Attention Disorders, 6(Supp. 1), 89-100.
7. Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50-55.
8. Hamilton, M. (1960). A rating scale for depression. Journal of Neurological and Neurosurgical Psychiatry, 23, 56-62.
9. National Institute of Mental Health. (1985). CGI (Clinical Global Impression) Scale-NIMH. Psychopharmacology Bulletin, 21, 839-844.
10. Orvaschel, H. (1994). Schedule for affective disorder and schizophrenia for school-age children epidemiologic version (5th ed.). Ft. Lauderdale, FL: Nova Southeastern University.
11. Pelham, W.E., Gnagy, E.M., Burrows-Maclean, L., Williams, A., Fabiano, G.A., Morrisey, S.M.,.Morse, G.D. (2001). Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics, 107, E105.
12. Spencer, T., & Adler, L. (2004). Diagnostic approaches to adult attention-deficit/hyperactivity disorder. Primary Psychiatry, 11, 49-53.
13. Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J.,.Faraone, S. (2005). A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biological Psychiatry, 57, 456-463.
14. Spencer, T., Biederman, J., Wilens, T., & Faraone, S.V. (1994). Is attention deficit hyperactivity disorder in adults a valid disorder? Harvard Review of Psychiatry, 1, 326-335.
15. Spencer, T.J., Biederman, J., Ciccone, P.E., Madras, B.K., Dougherty, D.D., Bonab, A.A.,.Fischman, A.J. (2006). A PET study examining pharmacokinetics, detection and like-ability, and dopamine transporter receptor occupancy of short and long-acting orally administered formulations of methylphenidate in adults. American Journal of Psychiatry, 163, 387-395.
16. Swanson, J., Greenhill, L., Pelham, W., Wilens, T., Wolraich, M., Abikoff, H.,.Winans, E. (2000). Initiating Concerta (OROS methylphenidate HCl) qd in children with attention-deficit hyperactivity disorder. Journal of Clinical Research, 3, 59-76.
17. Volkow, N.D., & Swanson, J.M. (2003). Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. American Journal of Psychiatry, 160, 1909-1918.
18. Wolraich, M.L., Greenhill, L.L., Pelham, W., Swanson, J., Wilens, T., Palumbo, D.,.August, G. (2001). Randomized controlled trial of OROS Methylphenidate qd in children with attention deficit/hyperactivity disorder. Pediatrics, 108, 883-892.