Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine

Headache

Volumn 51, Issue 4, 2011, Pages 544-553

  Hansen, Jakob M ^a   Thomsen, Lise L ^a   Olesen, Jes ^a   Ashina, Messoud ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Calcitonin gene related peptide; Cortical spreading depression; Familial hemiplegic migraine; Migraine; Neurotransmitters

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL HEMIPLEGIC MIGRAINE; FEMALE; GENE MUTATION; HUMAN; INCIDENCE; MALE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; PATHOGENESIS; PRIORITY JOURNAL; PROVOCATION TEST; VISUAL ANALOG SCALE;

ADULT; AGED; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MIGRAINE WITH AURA; MUTATION;

EID: 79953717741     PISSN: 00178748     EISSN: 15264610     Source Type: Journal    
DOI: 10.1111/j.1526-4610.2011.01861.x     Document Type: Article

References (40)

1. Villalon CM, Olesen J. The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs. Pharmacol Ther. 2009;124:309-323.
2. Olesen J, Diener HC, Husstedt IW, et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.N Engl J Med. 2004;350:1104-1110. (Pubitemid 38298990)
3. Ho TW, Mannix LK, Fan X, et al. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology. 2008;70:1304-1312. (Pubitemid 351550355)
4. Hansen JM, Hauge AW, Olesen J, Ashina M. Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia. 2010;30:1179-1186.
5. Lassen LH, Haderslev PA, Jacobsen VB, et al. CGRP may play a causative role in migraine. Cephalalgia. 2002;22:54-61. (Pubitemid 34626025)
6. Hansen J, Thomsen L, Olesen J, Ashina M. Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype. Neurology. 2008;71:841-847.
7. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 2004;24(Suppl. 1):9-160.
8. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996;87:543-552. (Pubitemid 26374327)
9. Dichgans M, Freilinger T, Eckstein G, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005;366:371-377. (Pubitemid 41073954)
10. De Fusco M, Marconi R, Silvestri L, et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003; 33:192-196. (Pubitemid 36177073)
11. Thomsen LL, Kirchmann M, Bjornsson A, et al. The genetic spectrum of a population-based sample of familial hemiplegic migraine. Brain. 2007;130:346-356. (Pubitemid 46181089)
12. Ducros A, Joutel A, Vahedi K, et al. Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. Ann Neurol. 1997;42:885-890. (Pubitemid 28008419)
13. Terwindt GM, Ophoff RA, Haan J, et al. Familial hemiplegic migraine:A clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Cephalalgia. 1996;16:153-155. (Pubitemid 26166181)
14. Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics. Pain. 1989;38:17-24. (Pubitemid 19184833)
15. Olesen J, Bousser MG, Diener HC, et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia. 2006;26:742-746.
16. Hansen JM, Thomsen LL, Olesen J, Ashina M. Coexisting typical migraine in familial hemiplegic migraine. Neurology. 2010;74:594-600.
17. Campbell MJ, Julious SA, Altman DG. Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons. BMJ. 1995;311:1145-1148.
18. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ. 1990;300:230-235. (Pubitemid 20045528)
19. Asghar MS, Hansen AE, Kapijimpanga T, et al. Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers. Neurology. 2010;75:1520-1526.
20. Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol. 1988;23:193-196. (Pubitemid 18081459)
21. Summ O, Charbit AR, Andreou AP, Goadsby PJ. Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus. Brain. 2010;133:2540-2548.
22. Sixt ML, Messlinger K, Fischer MJ. Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus. Brain. 2009;132:3134-3141.
23. Hansen JM, Thomsen LL, Olesen J, Ashina M. Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide. Cephalalgia. 2008;28:496-505. (Pubitemid 351502557)
24. Hansen JM, Thomsen LL, Marconi R, et al. Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine. Cephalalgia. 2008;28:367-375. (Pubitemid 351341452)
25. Christiansen I, Daugaard D, Lykke Thomsen L, Olesen J. Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency. Eur J Neurol. 2000;7:405-411. (Pubitemid 32280902)
26. Ducros A, Denier C, Joutel A, et al. The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. N Engl J Med. 2001;345:17-24. (Pubitemid 32634267)
27. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. 1981;9:344-352. (Pubitemid 11106551)
28. Hadjikhani N, Sanchez Del Rio M, Wu O, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001;98:4687-4692. (Pubitemid 32295037)
29. Nellgard B, Wieloch T. NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain. Acta Physiol Scand. 1992;146:497-503. (Pubitemid 23008348)
30. Moskowitz MA, Bolay H, Dalkara T. Deciphering migraine mechanisms: Clues from familial hemiplegic migraine genotypes. Ann Neurol. 2004;55:276-280. (Pubitemid 38167005)
31. van den Maagdenberg AM, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004;41:701-710. (Pubitemid 38326833)
32. van den Maagdenberg AM, Pizzorusso T, Kaja S, et al. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010;67:85-98.
33. Tottene A, Conti R, Fabbro A, et al. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron. 2009;61:762-773.
34. Prescot A, Becerra L, Pendse G, et al. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009;5:34. doi: 10.1186/1744-8069-5-34.
35. Anttila V, Stefansson H, Kallela M, et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet. 2010;42:869-873.
36. Russo AF, Kuburas A, Kaiser EA, et al. A potential preclinical migraine model: CGRP-sensitized mice. Mol Cell Pharmacol. 2009;1:264-270.
37. Xiao Y, Richter JA, Hurley JH. Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Mol Pain. 2008;4:12. doi: 10.1186/1744-8069-4-12.
38. Akerman S, Williamson DJ, Goadsby PJ. Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter release mechanism. Br J Pharmacol. 2003;140:558-566. (Pubitemid 37330500)
39. Reuter U, Weber JR, Gold L, et al. Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats. Am J Physiol. 1998; 274:H1979-H1987.
40. Bates E, Nikai T, Brennan K, et al. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010;30:170-180.