Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health

Journal of Proteome Research

Volumn 10, Issue 4, 2011, Pages 1667-1674

  Ruhaak, L Renee ^a,c   Uh, Hae Won ^a   Beekman, Marian ^a   Hokke, Cornelis H ^a   Westendorp, Rudi G J ^a   Houwing Duistermaat, Jeanine ^a   Wuhrer, Manfred ^a   Deelder, André M ^a   Slagboom, P Eline ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Netherlands Consortium of Healthy Aging ^*  (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aging; human plasma; longevity; N glycosylation

Indexed keywords

GLYCAN DERIVATIVE; GLYCOPROTEIN; LIPID; PLASMA PROTEIN;

ADULT; AGING; ARTICLE; BODY MASS; FEMALE; FLUORESCENCE; GLUCOSE HOMEOSTASIS; HEALTH; HEART INFARCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LONGEVITY; MALE; PRIORITY JOURNAL; PROGENY; PROTEIN GLYCOSYLATION; PROTEIN SECRETION;

AGED; AGED, 80 AND OVER; AGING; BLOOD PROTEINS; BODY MASS INDEX; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; FEMALE; GLUCOSE; GLYCOPROTEINS; GLYCOSYLATION; HEALTH; HUMANS; LONGEVITY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES;

EID: 79953712954     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr1009959     Document Type: Article

References (29)

1. Shental-Bechor, D.; Levy, Y. Folding of glycoproteins: toward understanding the biophysics of the glycosylation code Curr. Opin. Struct. Biol. 2009, 19 (5) 524-33
2. Fukuda, M. N.; Sasaki, H.; Lopez, L.; Fukuda, M. Survival of recombinant erythropoietin in the circulation: the role of carbohydrates Blood 1989, 73 (1) 84-9 (Pubitemid 19040958)
3. Gu, J.; Sato, Y.; Kariya, Y.; Isaji, T.; Taniguchi, N.; Fukuda, T. A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions J. Proteome Res. 2009, 8 (2) 431-5
4. Takahashi, M.; Kuroki, Y.; Ohtsubo, K.; Taniguchi, N. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins Carbohydr. Res. 2009, 344 (12) 1387-90
5. Marth, J. D.; Grewal, P. K. Mammalian glycosylation in immunity Nat. Rev. Immunol. 2008, 8 (11) 874-87
6. Ohtsubo, K.; Marth, J. D. Glycosylation in cellular mechanisms of health and disease Cell 2006, 126 (5) 855-67 (Pubitemid 44310784)
7. Arnold, J. N.; Saldova, R.; Hamid, U. M.; Rudd, P. M. Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation Proteomics 2008, 8 (16) 3284-93
8. Gornik, O.; Wagner, J.; Pucic, M.; Knezevic, A.; Redzic, I.; Lauc, G. Stability of N-glycan profiles in human plasma Glycobiology 2009, 19 (12) 1547-53
9. Packer, N. H.; von der Lieth, C. W.; Aoki-Kinoshita, K. F.; Lebrilla, C. B.; Paulson, J. C.; Raman, R.; Rudd, P.; Sasisekharan, R.; Taniguchi, N.; York, W. S. Frontiers in glycomics: bioinformatics and biomarkers in disease. An NIH white paper prepared from discussions by the focus groups at a workshop on the NIH campus, Bethesda MD (September 11-13, 2006) Proteomics 2008, 8 (1) 8-20
10. Knezevic, A.; Polasek, O.; Gornik, O.; Rudan, I.; Campbell, H.; Hayward, C.; Wright, A.; Kolcic, I.; ODonoghue, N.; Bones, J.; Rudd, P. M.; Lauc, G. Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome J. Proteome Res. 2009, 8 (2) 694-701
11. Vanhooren, V.; Desmyter, L.; Liu, X. E.; Cardelli, M.; Franceschi, C.; Federico, A.; Libert, C.; Laroy, W.; Dewaele, S.; Contreras, R.; Chen, C. N-glycomic changes in serum proteins during human aging Rejuvenation Res. 2007, 10 (4) 521-531a
12. Knezevic, A.; Gornik, O.; Polasek, O.; Pucic, M.; Redzic, I.; Novokmet, M.; Rudd, P. M.; Wright, A. F.; Campbell, H.; Rudan, I.; Lauc, G. Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans Glycobiology 2010, 20 (8) 959-69
13. Schoenmaker, M.; de Craen, A. J.; de Meijer, P. H.; Beekman, M.; Blauw, G. J.; Slagboom, P. E.; Westendorp, R. G. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study Eur. J. Hum. Genet. 2006, 14 (1) 79-84 (Pubitemid 43019087)
14. Westendorp, R. G.; van Heemst, D.; Rozing, M. P.; Frolich, M.; Mooijaart, S. P.; Blauw, G. J.; Beekman, M.; Heijmans, B. T.; de Craen, A. J.; Slagboom, P. E. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study J. Am. Geriatr. Soc. 2009, 57 (9) 1634-7
15. Rozing, M. P.; Westendorp, R. G.; Frolich, M.; de Craen, A. J.; Beekman, M.; Heijmans, B. T.; Mooijaart, S. P.; Blauw, G. J.; Slagboom, P. E.; van, H. D.; Group, O. B. Human insulin/IGF-1 and familial longevity at middle age Aging (Albany NY) 2009, 1 (8) 714-22
16. Heijmans, B. T.; Beekman, M.; Houwing-Duistermaat, J. J.; Cobain, M. R.; Powell, J.; Blauw, G. J.; van der, O. F.; Westendorp, R. G.; Slagboom, P. E. Lipoprotein particle profiles mark familial and sporadic human longevity PLoS Med. 2006, 3 (12) e495
17. Ruhaak, L. R.; Huhn, C.; Waterreus, W. J.; de Boer, A. R.; Neususs, C.; Hokke, C. H.; Deelder, A. M.; Wuhrer, M. Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins Anal. Chem. 2008, 80 (15) 6119-26
18. Skov, T.; Bro, R. Solving fundamental problems in chromatographic analysis Anal. Bioanal. Chem. 2008, 390 (1) 281-5
19. Stumpo, K. A.; Reinhold, V. N. The N-Glycome of Human Plasma J. Proteome Res. 2010, 9 (9) 4823-30
20. Parekh, R.; Roitt, I.; Isenberg, D.; Dwek, R.; Rademacher, T. Age-related galactosylation of the N-linked oligosaccharides of human serum IgG J. Exp. Med. 1988, 167 (5) 1731-6
21. Ruhaak, L. R.; Uh, H. W.; Beekman, M.; Koeleman, C. A. M.; Hokke, C. H.; Westendorp, R. G.; Wuhrer, M.; Houwing-Duistermaat, J. J.; Slagboom, P. E.; Deelder, A. M. Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity PLoS ONE 2010, 5 (9) e12566
22. Selman, M. H.; McDonnell, L. A.; Palmblad, M.; Ruhaak, L. R.; Deelder, A. M.; Wuhrer, M. Immunoglobulin G glycopeptide profiling by matrix-assisted laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry Anal. Chem. 2010, 82 (3) 1073-81
23. Shikata, K.; Yasuda, T.; Takeuchi, F.; Konishi, T.; Nakata, M.; Mizuochi, T. Structural changes in the oligosaccharide moiety of human IgG with aging Glycoconj. J. 1998, 15 (7) 683-9 (Pubitemid 28380331)
24. Yamada, E.; Tsukamoto, Y.; Sasaki, R.; Yagyu, K.; Takahashi, N. Structural changes of immunoglobulin G oligosaccharides with age in healthy human serum Glycoconj. J. 1997, 14 (3) 401-5 (Pubitemid 27231681)
25. Pepys, M. B.; Hirschfield, G. M. C-reactive protein: a critical update J. Clin. Invest. 2003, 111 (12) 1805-12 (Pubitemid 38057722)
26. Saldova, R.; Royle, L.; Radcliffe, C. M.; Abd Hamid, U. M.; Evans, R.; Arnold, J. N.; Banks, R. E.; Hutson, R.; Harvey, D. J.; Antrobus, R.; Petrescu, S. M.; Dwek, R. A.; Rudd, P. M. Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG Glycobiology 2007, 17 (12) 1344-56 (Pubitemid 350131311)
27. Campbell, M. P.; Royle, L.; Radcliffe, C. M.; Dwek, R. A.; Rudd, P. M. GlycoBase and autoGU: tools for HPLC-based glycan analysis Bioinformatics 2008, 24 (9) 1214-6 (Pubitemid 351594175)
28. Al-Regaiey, K. A.; Masternak, M. M.; Bonkowski, M.; Sun, L.; Bartke, A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction Endocrinology 2005, 146 (2) 851-60 (Pubitemid 40129843)
29. Bluher, M.; Kahn, B. B.; Kahn, C. R. Extended longevity in mice lacking the insulin receptor in adipose tissue Science 2003, 299 (5606) 572-4 (Pubitemid 36135156)