Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: Disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease

Cell Biochemistry and Function

Volumn 29, Issue 3, 2011, Pages 183-206

  Babizhayev, Mark A ^a,b  

^a Innovative Vision Products Incorporated   (United States)

^b MOSCOW HELMHOLTZ RESEARCH INSTITUTE OF EYE DISEASES   (Russian Federation)

Author keywords

Age related cataracts; Eye lens and aqueous humor; Lipid peroxidation and phospholipid hydroperoxides; Membrane derangement; Mitochondria and lens epithelial cells; Ophthalmic formulations of N acetylcarnosine and mitochondria targeted antioxidants; Reactive oxygen species generation

Indexed keywords

ALKADIENE; ANTIOXIDANT; ASCORBIC ACID; CATALASE; FLUORESCENT DYE; FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROPEROXIDE; LIPID HYDROPEROXIDE; LIPID PEROXIDASE; LUBRICATING AGENT; OXIDIZING AGENT; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

AQUEOUS HUMOR; ARTICLE; CATARACT; CONJUGATION; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; LENS; LENS EPITHELIUM; LIPID PEROXIDATION; MITOCHONDRION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REDUCTION;

AGED; AGING; ANIMALS; ANTIOXIDANTS; AQUEOUS HUMOR; CARNOSINE; CATARACT; FEMALE; HUMANS; HYDROGEN PEROXIDE; LENS, CRYSTALLINE; LIPID PEROXIDATION; LIPID PEROXIDES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MITOCHONDRIA; OPHTHALMIC SOLUTIONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHOLIPIDS; PRODRUGS; RABBITS; REACTIVE OXYGEN SPECIES;

MAMMALIA;

EID: 79953712311     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1737     Document Type: Article

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