Convenient synthesis of 4-tert-butyl 2-ethyl 3-amino-1-benzyl-5- dialkylamino-1H-pyrrole-2,4-dicarboxylate derivatives

Tetrahedron

Volumn 67, Issue 17, 2011, Pages 3124-3131

  Nishio, Yukihiro ^a   Uchiyama, Katsuya ^a   Kito, Makoto ^a   Nakahira, Hiroyuki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Pyrrole synthesis; Selective cyclization

Indexed keywords

2 ETHYL 4 METHYL 3 AMINO 1 BENZYL 5 [ 3 [(TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 (2 BROMO 5 FLUOROBENZYL) 5 [ 3 (TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 (2 METHYLBENZYL) 5 [METHYL(PROPYL)AMINO] 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 [4 (METHOXYCARBONYL)BENZYL] 5 (MORPHOLIN 4 YL) 1H 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 BENZYL 5 (AZEPAN 1 YL) 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 BENZYL 5 (PIPERIDIN 1 YL)- 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 BENZYL 5 [ 3 [(TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDIN 1 YL] 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 1 BENZYL 5 [BENZYL(METHYL)AMINO] 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 5 (AZEPAN 1 YL) 1 (2,6 DICHLOROBENZYL) 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 5 [ 4 (ETHOXYCARBONYL)PIPERIDIN 1 YL] 1 (4 METHOXYBENZYL) 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 5 [ 4 (TERT BUTOXYCARBONYL)PIPERADIN 1 YL] 1 (2 CHLOROBENZYL) 1H PYRROLE 2,4 DICARBOXYLATE; 4 TERT BUTYL 2 ETHYL 3 AMINO 5 [2 (METHOXYMETHYL)PYRROLIDINE 1 YL] 1 [3 (TRIFLUOROMETHYL)BENZYL] 1H PYRROLE 2,4 DICARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; LITHIUM; METHYL 3 [BENZY(2 ETHOXY 2 OXOETHYL)LAMINO] 3 [ 3 [(TERTBUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 2 CYANOPROP 2 ENOATE; TERT BUTYL 3 (BENZYLAMINO) 3 [ 3 [(TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 2 CYANOPROP 2 ENOATE; TERT BUTYL 3 [ 3 [(TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 2 CYANO 3 (METHYLTHIO)ACRYLATE; TERT BUTYL 3 [BENZY(2 ETHOXY 2 OXOETHYL)LAMINO] 3 [ 3 [(TERT BUTOXYCARBONYL)AMINO] 3 METHYLPIPERIDINE 1 YL] 2 CYANO PROP 2 ENOATE; UNCLASSIFIED DRUG;

ARTICLE; COLUMN CHROMATOGRAPHY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; PURIFICATION; STEREOSPECIFICITY;

EID: 79953706554     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2011.02.071     Document Type: Article

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