What did we learn from the genome-wide association study for tuberculosis susceptibility?

Journal of Medical Genetics

Volumn 48, Issue 4, 2011, Pages 217-218

  Qu, Hui Qi ^a   Li, Quan ^b   McCormick, Joseph B ^a   Fisher Hoch, Susan P ^a  

^a UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12P40;

GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HEREDITY; NOTE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULIN TEST; TUBERCULOSIS;

COHORT STUDIES; COMPUTER SIMULATION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; TUBERCULOSIS;

EID: 79953701922     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmg.2010.087361     Document Type: Note

References (11)

1. Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A, Morris AP, Meyer CG, Horstmann RD, Hill AVS. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet 2010;42:739-41.
2. Stead WW, Senner JW, Reddick WT, Lofgren JP. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 1990;322:422-7.
3. Comstock GW. Tuberculosis in twins: a re-analysis of the Prophit survey. Am Rev Respir Dis 1978;117:621-4.
4. Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease. J Clin Invest 2008;118:1590-605.
5. Casanova JL, Blanche S, Emile JF, Jouanguy E, Lamhamedi S, Altare F, Stephan JL, Bernaudin F, Bordigoni P, Turck D, Lachaux A, Albertini M, Bourrillon A, Dommergues JP, Pocidalo MA, Le Deist F, Gaillard JL, Griscelli C, Fischer A. Idiopathic disseminated bacillus Calmette-Guerin infection: a French national retrospective study. Pediatrics 1996;98(4 Pt 1):774-8.
6. North RJ, Jung YJ. Immunity to tuberculosis. Ann Rev Immunol 2004;22:599-623.
7. Lienhardt C, Bennett S, Del Prete G, Bah-Sow O, Newport M, Gustafson P, Manneh K, Gomes V, Hill A, McAdam K. Investigation of environmental and hostrelated risk factors for tuberculosis in Africa. I. Methodological aspects of a combined design. Am J Epidemiol 2002;155:1066-73.
8. Bennett S, Lienhardt C, Bah-Sow O, Gustafson P, Manneh K, Del Prete G, Gomes V, Newport M, McAdam K, Hill A. Investigation of environmental and host-related risk factors for tuberculosis in Africa. II. Investigation of host genetic factors. Am J Epidemiol 2002;155:1074-9.
9. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin d-mediated human antimicrobial response. Science 2006;311:1770-3.
10. Nicholson S, Bonecini-Almeida Mda G, Lapa e Silva JR, Nathan C, Xie QW, Mumford R, Weidner JR, Calaycay J, Geng J, Boechat N, Linhares C, Rom W, Ho JL. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med 1996;183:2293-302.
11. Kavvoura FK, Ioannidis JP. Methods for metaanalysis in genetic association studies: a review of their potential and pitfalls. Hum Genet 2008;123:1-14.