Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin

Cellular and Molecular Life Sciences

Volumn 68, Issue 6, 2011, Pages 1065-1077

  Porté, Sergio ^a   Moeini, Agrin ^a   Reche, Irene ^a   Shafqat, Naeem ^b   Oppermann, Udo ^b,c   Farrés, Jaume ^a   Parés, Xavier ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Alkenal one reductase; Double bond , hydrogenation; Lipid peroxidation products; Medium chain dehydrogenases reductases; Quinone oxidoreductase

Indexed keywords

2 ALKENAL DERIVATIVE; 2 ALKENONE DERIVATIVE; 4 HYDROXYHEXENAL; ALDEHYDE; ALKENAL REDUCTASE; KETONE; OXIDOREDUCTASE; QUINONE OXIDOREDUCTASE; TYROSINE; UNCLASSIFIED DRUG; ZETA CRYSTALLIN; ZINC ION;

ARTICLE; DETOXIFICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HYDROGENATION; LIPID PEROXIDATION; MOLECULAR DOCKING; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN FUNCTION; SIMULATION;

ALDEHYDES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROGENATION; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; ZETA-CRYSTALLINS;

EID: 79953701028     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0508-2     Document Type: Article

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