Biophysical probes reveal a "compromise" Nature of the Methyl-lysine Binding Pocket in L3MBTL1

Journal of the American Chemical Society

Volumn 133, Issue 14, 2011, Pages 5357-5362

  Gao, Cen ^a   Herold, J Martin ^a   Kireev, Dmitri ^a   Wigle, Tim ^a   Norris, Jacqueline L ^a   Frye, Stephen ^a  

^a University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; ATOMIC LEVELS; BINDING AFFINITIES; BINDING POCKETS; BIOLOGICAL PROCESS; EXPERIMENTAL METHODS; FAVORABLE INTERACTIONS; FREE ENERGY PERTURBATION; HISTONE CODES; HISTONE LYSINE METHYLATION; ISOTHERMAL TITRATION CALORIMETRY; LYSINE RESIDUES; RECOGNITION MECHANISM; TRANSCRIPTIONAL REGULATION;

ALKYLATION; BINDING ENERGY; FREE ENERGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; METHYLATION; MOLECULAR DYNAMICS; PROBES; PROTEINS;

AMINO ACIDS;

HISTONE; LYSINE; METHYL GROUP; PROTEIN; PROTEIN L3MBTL1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; ENERGY; ENERGY TRANSFER; EXPERIMENT; ISOTHERMAL TITRATION CALORIMETRY; METHYLATION; MOLECULAR DYNAMICS; REPRODUCIBILITY; TRANSCRIPTION REGULATION; VALIDATION STUDY;

BINDING SITES; BIOMIMETIC MATERIALS; HISTONES; LYSINE; METHYLATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR PROBES; NUCLEAR PROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 79953694494     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja110432e     Document Type: Article

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