Single-molecule imaging revealed enhanced dimerization of transforming growth factor β type II receptors in hypertrophic cardiomyocytes

Biochemical and Biophysical Research Communications

Volumn 407, Issue 2, 2011, Pages 313-317

  He, Kangmin ^a,b   Fu, Yongnan ^b   Zhang, Wei ^a   Yuan, Jinghe ^a   Li, Zijian ^b   Lv, Zhizhen ^b   Zhang, Youyi ^b   Fang, Xiaohong ^a  

^a INSTITUTE OF CHEMISTRY   (China)

^b Peking University Health Science Center   (China)

Author keywords

Angiotensin II; Hypertrophic cardiomyocyte; Phenylephrine; Single molecule imaging; Transforming growth factor type II receptors

Indexed keywords

ANGIOTENSIN II; PHENYLEPHRINE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; FLUORESCENCE IMAGING; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IMMUNOFLUORESCENCE; MOLECULAR IMAGING; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOMEGALY; MICROSCOPY, FLUORESCENCE; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 79953692667     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.008     Document Type: Article

References (23)

1. Molkentin J.D., Dorn G.W. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu. Rev. Physiol. 2001, 63:391-426.
2. Wang J., Xu N., Feng X., Hou N., Zhang J., Cheng X., Chen Y., Zhang Y., Yang X. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ. Res. 2005, 97:821-828.
3. Bujak M., Frangogiannis N.G. The role of TGF-β signaling in myocardial infarction and cardiac remodeling. Cardiovasc. Res. 2007, 74:184-195.
4. Schlüter K.D., Zhou X.J., Piper H.M. Induction of hypertrophic responsiveness to isoproterenol by TGF-β in adult rat cardiomyocytes. Am. J. Physiol. 1995, 269:C1311-C1316.
5. Rosenkranz S., Flesch M., Amann K., Haeuseler C., Kilter H., Seeland U., Schlüter K.D., Böhm M. Alterations of β-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β(1). Am. J. Physiol. Heart Circ. Physiol. 2002, 283:253-262.
6. Schultz Jel.J., Witt S.A., Glascock B.J., Nieman M.L., Reiser P.J., Nix S.L., Kimball T.R., Doetschman T. TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J. Clin. Invest. 2002, 109:715-716.
7. Lim J.Y., Park S.J., Hwang H.Y., Park E.J., Nam J.H., Kim J., Park S.I. TGF-β1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. J. Mol. Cell. Cardiol. 2005, 39:627-636.
8. Xiao H., Zhang Y.Y. Understanding the role of transforming growth factor-β signalling in the heart: overview of studies using genetic mouse models. Clin. Exp. Pharmacol. Physiol. 2008, 35:335-341.
9. Chen H., Yong W., Ren S., Shen W., He Y., Cox K.A., Zhu W., Li W., Soonpaa M., Payne R.M., Franco D., Field L.J., Rosen V., Wang Y., Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. J. Biol. Chem. 2006, 281:27481-27491.
10. Hebert T.E., Moffett S., Morello J.P., Loisel T.P., Bichet D.G., Barret C., Bouvier M. A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J. Biol. Chem. 1996, 27:16384-16392.
11. Rios C.D., Jordan B.A., Gomes I., Devi L.A. G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol. Ther. 2001, 92:71-87.
12. Breitwieser G.E. Activation and cell signaling G protein-coupled receptor oligomerization: implications for G protein. Circ. Res. 2004, 94:17-27.
13. Zhang W., Jiang Y., Wang Q., Ma X., Xiao Z., Zuo W., Fang X., Chen Y.G. Single-molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc. Natl. Acad. Sci. USA 2009, 106:15679-15683.
14. Zhang W., Yuan J.H., Yang Y., Xu L., Wang Q., Zuo W., Fang X.H., Chen Y.G. Monomeric type I and type III transforming growth factor-β receptors and their dimerization revealed by single-molecule imaging. Cell Res. 2010, 20:1216-1223.
15. Liao W., Wang S., Han C., Zhang Y. 14-3-3 proteins regulate glycogen synthase 3 beta phosphorylation and inhibit cardiomyocyte hypertrophy. FEBS J. 2005, 272:1845-1854.
16. Ji W., Xu P., Li Z., Lu J., Liu L., Zhan Y., Chen Y., Hille B., Xu T., Chen L. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc. Natl. Acad. Sci. USA 2008, 105:13668-13673.
17. Ulbrich M.H., Isacoff E.Y. Subunit counting in membrane-bound proteins. Nat. Meth. 2007, 4:319-321.
18. Kohout S.C., Ulbrich M.H., Bell S.C., Isacoff E.Y. Subunit organization and functional transitions in Ci-VSP. Nat. Struct. Mol. Biol. 2008, 15:106-108.
19. Gray M.O., Long C.S., Kalinyak J.E., Li H.T., Karliner J.S. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β 1 and endothelin-1 from fibroblasts. Cardiovasc. Res. 1998, 40:352-363.
20. Taylor J.M., Rovin J.D., Parsons J.T. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. J. Biol. Chem. 2000, 275:19250-19257.
21. Sano M., Fukuda K., Kodama H., Pan J., Saito M., Matsuzaki J., Takahashi T., Makino S., Kato T., Ogawa S. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J. Biol. Chem. 2000, 275:29717-29723.
22. Liao Y., Takashima S., Asano Y., Asakura M., Ogai A., Shintani Y., Minamino T., Asanuma H., Sanada S., Kim J., Ogita H., Tomoike H., Hori M., Kitakaze M. Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model. Circ. Res. 2003, 93:759-766.
23. Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signaling. Nature 2000, 425:577-584.