Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response

Microbiology

Volumn 157, Issue 4, 2011, Pages 1187-1195

  Nessar, Rachid ^a   Reyrat, Jean Marc ^a   Davidson, Lisa B ^b   Byrd, Thomas F ^b,c  

^a INSERM   (France)

^b NEW MEXICO VA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPEPTIDOLIPID; LIPID; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BIOFILM; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MMPL4B GENE; MYCOBACTERIUM ABSCESSUS; NONHUMAN; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CELLS, CULTURED; GENE DELETION; GLYCOPEPTIDES; HUMANS; IMMUNITY, INNATE; LIPOPEPTIDES; MACROPHAGES; MYCOBACTERIUM; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM ABSCESSUS;

EID: 79953678666     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.046557-0     Document Type: Article

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