Cyanide in bronchoalveolar lavage is not diagnostic for Pseudomonas aeruginosa in children with cystic fibrosis

European Respiratory Journal

Volumn 37, Issue 3, 2011, Pages 553-558

  Stutz, M D ^a,b   Gangell, C L ^a   Berry, L J ^a   Garratt, L W ^a   Sheil, B ^a   Sly, P D ^a,c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b MURDOCH UNIVERSITY   (Australia)

^c PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

Author keywords

Biomarker; Cyanide; Cystic fibrosis; Pseudomonas aeruginosa

Indexed keywords

BIOLOGICAL MARKER; CYANIDE;

ARTICLE; CHILD; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; FEMALE; HEALTH SURVEY; HUMAN; INFANT; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; NONHUMAN; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE; CALIBRATION; CHILD; CHILD, PRESCHOOL; CYANIDES; CYSTIC FIBROSIS; FEMALE; HUMANS; INFANT; LONGITUDINAL STUDIES; LUNG DISEASES; MALE; MICROSCOPY, FLUORESCENCE; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 79953677459     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00024210     Document Type: Article

References (24)

1. Kosorok MR, Zeng L, West SE, et al. Acceleration of lung disease in children with cystic fibrosis after Pseudomonas aeruginosa acquisition. Pediatr Pulmonol 2001; 32: 277-287. (Pubitemid 32938876)
2. Emerson J, Rosenfeld M, McNamara S, et al. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol 2002; 34: 91-100. (Pubitemid 34809519)
3. Nixon GM, Armstrong DS, Carzino R, et al. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr 2001; 138: 699-704. (Pubitemid 32417671)
4. Douglas TA, Brennan S, Gard S, et al. Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis. Eur Respir J 2009; 33: 305-311.
5. Hansen CR, Pressler T, Høiby N. Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience. J Cyst Fibros 2008; 7: 523-530.
6. Brennan S, Gangell C, Wainwright C, et al. Disease surveillance using bronchoalveolar lavage. Paediatr Respir Rev 2008; 9: 151-159.
7. Socransky SS, Gibbons RJ, Dale AC, et al. The microbiota of the gingival crevice area of man. I. Total microscopic and viable counts and counts of specific organisms. Arch Oral Biol 1963; 8: 275-280.
8. Blumer C, Haas D. Mechanism, regulation and ecological role of bacterial cyanide biosynthesis. Arch Microbiol 2000; 173: 170-177. (Pubitemid 30143574)
9. Castric PA. Hydrogen cyanide production by Pseudomonas aeruginosa at reduced oxygen levels. Can J Microbiol 1983; 29: 1344-1349. (Pubitemid 14191527)
10. Worlitzsch D, Tarran R, Ulrich M, et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 2002; 109: 317-325. (Pubitemid 34141805)
11. Enderby B, Smith D, Carroll W, et al. Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis. Pediatr Pulmonol 2009; 44: 142-147.
12. Ryall B, Davies JC, Wilson R, et al. Pseudomonas aeruginosa, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients. Eur Respir J 2008; 32: 740-747.
13. Sanderson K, Wescombe L, Kirov SM, et al. Bacterial cyanogenesis occurs in the cystic fibrosis lung. Eur Respir J 2008; 32: 329-333.
14. Sly PD, Brennan S, Gangell C, et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009; 180: 146-152.
15. Australian Respiratory Early Surveillance Team for Cystic Fibrosis. AREST CF. www.arestcf.org Date last updated: August, 8: 2010.
16. Ryall B, Lee X, Zlosnik JE, et al. Bacteria of the Burkholderia cepacia complex are cyanogenic under biofilm and colonial growth conditions. BMC Microbiol 2008; 8: 108.
17. Rosenfeld M, Gibson RL, McNamara S, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol 2001; 32: 356-366. (Pubitemid 33015652)
18. Stelmaszyńska T. Formation of HCN by human phagocytosing neutrophils - 1. Chlorination of Staphylococcus epidermidis as a source of HCN. Int J Biochem 1985; 17: 373-379. (Pubitemid 15086262)
19. 2-Cl- system. Biochim Biophys Acta 1979; 567: 309-314.
20. Stelmaszyńska T. Formation of HCN and its chlorination to ClCN by stimulated human neutrophils - 2. Oxidation of thiocyanate as a source of HCN. Int J Biochem 1986; 18: 1107-1114. (Pubitemid 17215998)
21. Pollock JR, Goff HM. Lactoperoxidase-catalyzed oxidation of thiocyanate ion: a carbon-13 nuclear magnetic resonance study of the oxidation products. Biochim Biophys Acta 1992; 1159: 279-285.
22. Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, et al. Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol 2003; 29: 206-212. (Pubitemid 36936648)
23. Furtmüller PG, Burner U, Obinger C. Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate. Biochemistry (Mosc) 1998; 37: 17923-17930. (Pubitemid 29023948)
24. Stamyr K, Vaittinen O, Jaakola J, et al. Background levels of hydrogen cyanide in human breath measured by infrared cavity ring down spectroscopy. Biomarkers 2009; 14: 285-291.