Anti-ulcer activity of the 9alpha-bromo analogue of Beclomethasone dipropionate against ethanol-induced gastric mucosal injury in rats

Journal of Medicinal Plants Research

Volumn 5, Issue 4, 2011, Pages 514-520

  Ketuly, Kamal A ^a   Abdulla, Mahmood A ^a   Hadi, Hamid A ^a   Mariod, Abdalbasit A ^b   Abdel Wahab, Siddig Ibrahim ^c  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b SUDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Sudan)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Beclomethasone dipropionate derivatives; Cytoprotection; Natural products; Ulcer

Indexed keywords

9ALPHA BROMOBECLOMETASONE DIPROPIONATE; ALCOHOL; GLUCOCORTICOID; OMEPRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; EDEMA; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; STOMACH ACID SECRETION; STOMACH MUCOSA INJURY; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; STOMACH WALL; ULCER HEALING;

RATTUS;

EID: 79953675674     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Abd El-Dayem A, El-Agaimy M (1992). Non-wood forest products, physico-chemical characteristics and fatty acid composition of three seed oils. ISHS, pp. 287-294.
2. Bou-Abboud C, Wayland H, Paulsen G, Guth P (1988). Microcirculatory stasis precedes tissue necrosis in ethanol-induced gastric mucosal injury in the rat. Dig. Dis. Sci., 33: 872-877.
3. Cheng C, Koo M (2000). Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci.,67: 2647-2653.
4. Davenport H (1968). Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterol., 54: 175.
5. De Pasquale R, German M, Keita A, Sanogo R, Iauk L (1995). Antiulcer activity of Pteleopsis suberosa. J. ethnopharmacol., 47: 55-58.
6. Garg G, Nigam S, Ogle C (1993). Gastric antiulcer effects of the leaves of the neem tree. Planta medica, 59: 215-215.
7. Hoare C, Li W, Williams H (2000). Systematic review of treatments for atopic eczema. Health technology assessment (Winchester, England), 4: 1.
8. Kato S, Kawase T, Alderman J, Inatomi N, Lieber C (1990). Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats. Gastroenterol., 98: 203-210.
9. Kauffman Jr G, Grossman M (1978). Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates. Gastroenterol., 75: 1099.
10. Ketuly K, Aadi A, Ng S (2009). 9-Bromo analog of beclometasone dipropionate monohydrate. Acta Crystallographica Section E: Structure Reports Online, 65: o1821.
11. Ketuly KA (1988). Glaxo Group Research (now Glaxo Smith Kline). In: E. Report (Ed.), No. WAP/88/007, 1988.
12. Kobayashi T, Ohta Y, Yoshino J, Nakazawa S (2001). Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues. Pharmacol. Res., 43: 23-30.
13. Li X, Andersson T, Ahlström M, Weidolf L (2004). Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab. Dispos., 32: 821.
14. Marhuenda E, Martin M, De La A, Lastra C (1993). Antiulcerogenic activity of aescine in different experimental models. Phytother. Res., 7: 13-16.
15. Nagaya H, Inatomi N, Nohara A, Satoh H (1991). Effects of the enantiomers of lansoprazole (AG-1749) on (H++ K+)-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells. Biochem. Pharmacol., 42: 1875-1878.
16. Njar V, Adesanwo J, Raji Y (1995). Methyl Angolenate: Antiulcer Agent from the Stem Bark of Entandrophragma angolense. Planta Medica., 61: 91-91.
17. Nordmann R (1994). Alcohol and antioxidant systems. Alcohol Alcohol., 29: 513.
18. Paiva L, Rao V, Gramosa N, Silveira E (1998). Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats. J. Ethnopharmacol., 62: 73-78.
19. Patton J (1998). Breathing life into protein drugs. Nat. Biotechnol., 16: 141-143.
20. Pedernera A, Guardia T, Calderón C, Rotelli A, de la Rocha N, Genaro S, Pelzer L (2006). Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. J. Ethnopharmacol., 105: 415-420.
21. Rizzello F, Gionchetti P, D'Arienzo A, Manguso F, Di Matteo G, Annese V, Valpiani D, Casetti T, Adamo S, Prada A (2002). Oral beclometasone dipropionate in the treatment of active ulcerative colitis: a double blind placebo controlled study. Aliment. Pharmacol. Ther., 16: 1109-1116.
22. Rujjanawate C, Kanjanapothi D, Amornlerdpison D, Pojanagaroon S (2005). Anti-gastric ulcer effect of Kaempferia parviflora. J. Ethnopharmacol., 102: 120-122.
23. Salim A (1990). Removing oxygen-derived free radicals stimulates healing of ethanol-induced erosive gastritis in the rat. Dig. 47: 24-28.
24. Satoh H, Inatomi N, Nagaya H, Inada I, Nohara A, Nakamura N, Maki Y (1989). Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J. Pharmacol. Exp. Ther., 248: 806.
25. Schreiber C, Hutchinson S, Webster C, Ames M, Richardson M, Powers C (2004). Prevalence of migraine in patients with a history of selfreported or physician-diagnosed" sinus" headache. Arch. Intern. Med., 164: 1769.
26. Shimizu N, Watanabe T, Arakawa T, Fujiwara Y, Higuchi K, Kuroki T (2000). Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing. Dig., 61: 157-164.
27. Suzuki Y, Ishihara M, Segami T, Ito M (1998). Anti-ulcer effects of antioxidants, quercetin,-tocopherol, nifedipine and tetracycline in rats. Jpn. J. Pharmacol., 78: 435-441.
28. Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze A, Jadus M (1995). Growth factors: new'endogenous drugs' for ulcer healing. Scand. J. Gastroenterol., 30: 15-18.
29. Tan P, Nyasse B, Dimo T, Mezui C (2002). Gastric cytoprotective antiulcer effects of the leaf methanol extract of Ocimum suave (Lamiaceae) in rats. J. Ethnopharmacol., 82: 69-74.
30. Tsukimi Y, Nozue C, Okabe S (1996). Effects of leminoprazole, omeprazole and sucralfate on indomethacininduced delayed healing of kissing gastric ulcers in rats. J. Gastroenterol. Hepatol., 11: 335-340.
31. Zimmerman J, Ciesielski W, Lewandoski J (1997). Neutrophil-mediated phospholipid peroxidation assessed by gas chromatography-mass spectroscopy. Am. J. Physiol. Cell Physiol., 273: C653.