Gastric cytoprotective anti-ulcer effects of the leaf methanol extract of Ocimum suave (Lamiaceae) in rats

Journal of Ethnopharmacology

Volumn 82, Issue 2-3, 2002, Pages 69-74

  Tan, Paul V ^a   Nyasse, Barthelemy ^a   Dimo, Theophile ^a   Mezui, Christophe ^a  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

Gastric cytoprotection; Lamiaceae; Ocimum suave

Indexed keywords

ALCOHOL; ANTACID AGENT; ANTIULCER AGENT; HYDROCHLORIC ACID; INDOMETACIN; METHANOL DERIVATIVE; OCIMUM SUAVE EXTRACT; PLANT EXTRACT; RANITIDINE; STOMACH SECRETION INHIBITOR; SUCRALFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MUCUS SECRETION; NONHUMAN; PYLORUS LIGATION; RAT; STOMACH ACID SECRETION; STOMACH LESION; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; STOMACH SECRETION; STOMACH ULCER; ULCER HEALING;

ANIMALS; ANTI-ULCER AGENTS; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; LAMIACEAE; MALE; METHANOL; OCIMUM; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 0036803265     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00142-3     Document Type: Article

References (27)

1. Adjanohoun, J.E., Aboubakar, N., Dramane, K., Ebot, M.E., Ekpere, J.A., Enow-Orock, E.G., Focho, D., Gbile, Z.O., Kamanyi, A., Kamsu-Kom, J., Keita, A., Mbenkum, T., Mbi, C.N., Mbiele, A.L., Mbome, L.L., Mubiru, N.K., Nancy, W.L., Nkongmeneck, B., Satabie, B., Sofowora, A., Tamze, V., Wirmum, C.K., 1996. Traditional Medicine and Pharmacopoeia: Contribution to Ethnobotanical and Floristic Studies in Cameroon. Organisation of African Unity Scientific, Technical and Research Commission. Centre National de Production de Manuels Scolaires, Porto-Novo, pp. 263.
2. Akhtar A.H., Ahmad K.U. Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in Aspirin-ulcerated rats. Journal of Ethnopharmacology. 46:(1):1995;1-6.
3. Bouquet, A., 1969. Féticheurs et Médicine traditionnelles au Congo (Brazzaville). Memoire O.R.S.T.O.M. No. 36. Pris, pp. 49, 100, 198.
4. Burger, W.C., 1967. Families of flowering plants in Ethiopia. An Oklahoma State University USAID contract publication. Experimentation Bulletin No. 45, pp. 117.
5. 2-receptor antagonists: standard therapy for acid-peptic diseases. The New England Journal of Medicine. 323:(24):1990;1672-1680.
6. 3 transport by mammalian duodenum in vivo. American Journal of Physiology (Gastrointestinal Liver Physiology). 234:1982;G348-G358.
7. Hara N., Okabe S. Effect of gefernate on acute lesions in rats. Folio Pharmacologica Japonica. 85:1985;443-448.
8. Hutchinson, J., Daziel, J.M., 1963. Flora of West Tropical Africa. Published on behalf of the Governments of Nigeria, Ghana and Sierra Leone. Crown Agents for Overseas Governments and Administrations, London, 2, pp. 451.
9. Konturek S.J., Piastucki I., Brozozowski T., Dembiska-kiec T.R.A., Muda A., Gryglewski R. Role of prostaglandins in the formation of aspirin-induced ulcers. Gastroenterology. 80:1981;4-9.
10. Konturek S.J., Brozozowski T., Piastucki I., Radecki T., Dembiski-kiec A. Role of locally generated prostaglandins in adaptive cytoprotection. Digestive Diseases and Science. 27:1982;967-971.
11. Martin M.J., Motilva V., Alarcon de la Lastra C. Quercetin and Naringenin: effects on ulcer formation and gastric secretion in rats. Phytotherapy Research. 7:1993;150-153.
12. Miller T.A. Protective effect of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. American Journal of Physiology (Gastrointestinal and Liver Physiology 8). 245:1982;G601-G603.
13. Mshana, N.R., Abbiw, D.K., Addae-Mensah, I., Adjanohoun, E., Ahyi, M.R.A., Enow-Orock, E.G., Gbile, Z.O., Noamesi, B.K., Odei, M.A., Adunlami, H., Oteng-Yeboah, A.A., Sarpong, K., Sofowora, A., Tackie, A.N., 2000. Traditional Medicine and Pharmacopoeia. Contribution to the Revision of Ethnobotanical and Floristic Studies in Ghana. Scientific, Technical and Research Commission of the Organization of African Unity, pp. 290-293.
14. Oates P.J., Hakkinen J.P. Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology. 94:1988;10-21.
15. Raynal, J., Troupin, G., Sita, P., 1979. Flore et medicine traditionnelles. Mission d'étude 1979 au Rwanda. Rapport Présenté à l'Agence de Coopération Culturelle et Technique (A.C.C.T). Paris, pp. 126.
16. Robert A. Prostaglandins and the gastroduodenal tract. Johnson L.R., Physiology of the Gastrointestinal Tract. 1981;1407-1434 Raven Press, New York.
17. Robert A., Nezamis J.E., Lancaster C., Davis J.P., Field S.O., Hanchar A.J. Mild irritants prevent gastric necrosis through 'adaptive cytoprotection' mediated by prostaglandins. American Journal of Physiology (Gastrointestinal and Liver Physiology 8). 245:1983;G113-G121.
18. Shay J.P., Komarov S.A., Fels S.S., Meranze D., Grunstein M., Simpler H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 5:1945;43-61.
19. 2 output in human subjects. Annals of Internal Medicine. 106:1987;368-371.
20. Sun Z., Matsumoto T., Yamada H. Anti-ulcer activity and mode of action of the polysaccharide fraction from the leaves of Panax ginseng. Planta Medica. 58:1992;432-435.
21. Tan P.V., Nditafon G.N., Yewah M.P., Ayafor J.F., Dimo T. Eremomastax speciosa: effects of leaf aqueous extract on ulcer formation and gastric secretion in rats. Journal of Ethnopharmacology. 54:1996;139-142.
22. Tan P.V., Njimi C.K., Ayafor J.F. Screening of some African medicinal plants for anti-ulcerogenic activity. Part I. Phytotherapy Research. 11:1997;45-47.
23. Tan P.V., Penlap V.B., Barthelemy N., Nguemo J.D.B. Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats. Journal of Ethnopharmacology. 73:2000;423-428.
24. Thonner Fr. Flowering Plants of Africa. 1915;472 Wheldon and Wesley Ltd Publishing Company CODICOTE Herta, New York. Reprint at 1962 by Cramer and Hafner.
25. Vatier J., Vallot T. Antacides. Pharmacologie. Des concepts fondamentaux aux applications thérapeutiques. 1998;555-565 Frison-Roche, Paris.
26. Watt J.M., Gerdinat M., Breyer-Brandwij K. Medicinal and Poisonous Plants of Southern and Eastern Africa. second ed. 1962;524, 1307 E & S Lwinstone Ltd, London.
27. Whittle B.J.R. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile salts, and the actions of prostaglandins. British Journal of Pharmacology. 60:1977;455-460.