From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Pathak, Amit ^a   Kumar, Sanjay ^a  

^a University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE;

ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; EXTRACELLULAR MATRIX; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MATHEMATICAL MODEL; MECHANOTRANSDUCTION; PHASE CONTRAST MICROSCOPY; CELL MOTION; GENETICS; METABOLISM; PHYSIOLOGY; THEORETICAL MODEL;

EUKARYOTA;

ACTOMYOSIN; CELL MOVEMENT; EXTRACELLULAR MATRIX; MECHANOTRANSDUCTION, CELLULAR; MODELS, THEORETICAL; RAC GTP-BINDING PROTEINS;

EID: 79953658445     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018423     Document Type: Article

References (35)

1. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, et al. (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139: 891-906.
2. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, et al. (2003) Cell migration: Integrating signals from front to back. Science 302: 1704-1709.
3. Lauffenburger DA, Horwitz AF, (1996) Cell migration: A physically integrated molecular process. Cell 84: 359-369.
4. DiMilla PA, Barbee K, Lauffenburger DA, (1991) Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophysical Journal 60: 15-37.
5. Zemel A, Rehfeldt F, Brown AEX, Discher DE, Safran SA, (2010) Optimal matrix rigidity for stress-fibre polarization in stem cells. Nat Phys advance online publication.
6. Engler A, Bacakova L, Newman C, Hategan A, Griffin M, et al. (2004) Substrate compliance versus ligand density in cell on gel responses. Biophysical Journal 86: 617-628.
7. Peyton SR, Putnam AJ, (2005) Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. Journal of Cellular Physiology 204: 198-209.
8. Ulrich TA, de Juan Pardo EM, Kumar S, (2009) The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Research 69: 4167-4174.
9. Zaman MH, Kamm RD, Matsudaira P, Lauffenburger DA, (2005) Computational model for cell migration in three-dimensional matrices. Biophysical Journal 89: 1389-1397.
10. Zaman MH, Trapani LM, Sieminski AL, MacKellar D, Gong H, et al. (2006) Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proceedings of the National Academy of Sciences, USA 103: 10889-10894.
11. Chan CE, Odde DJ, (2008) Traction dynamics of filopodia on compliant substrates. Science 322: 1687-1691.
12. Herant M, Dembo M, (2010) Form and Function in Cell Motility: From Fibroblasts to Keratocytes. Biophysical Journal 98: 1408-1417.
13. Herant M, Marganski WA, Dembo M, (2003) The Mechanics of Neutrophils: Synthetic Modeling of Three Experiments. Biophysical Journal 84: 3389-3413.
14. Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, et al. (2008) Actin and [alpha]-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol 10: 1039-1050.
15. Mogilner A, Oster G, (1996) Cell motility driven by actin polymerization. Biophysical Journal 71: 3030-3045.
16. Mogilner A, Rubinstein B, (2005) The Physics of Filopodial Protrusion. Biophysical Journal 89: 782-795.
17. Nicolas A, Geiger B, Safran SA, (2004) Cell mechanosensitivity controls the anisotropy of focal adhesions. Proceedings of the National Academy of Sciences, USA 101: 12520-12525.
18. Nishimura SI, Ueda M, Sasai M, (2009) Cortical Factor Feedback Model for Cellular Locomotion and Cytofission. PLoS Comput Biol 5: e1000310.
19. Walcott S, Sun SX, (2010) A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells. Proceedings of the National Academy of Sciences, USA 107: 7757-7762.
20. Huxley AF, Simmons RM, (1971) Proposed mechanism of force generation in striated muscle. Nature 233: 533-538.
21. Bell GI, (1978) Models for the specific adhesion of cells to cells. Science 200: 618-627.
22. Vogel V, Sheetz MP, (2009) Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Current Opinion in Cell Biology 21: 38-46.
23. Merkel R, Nassoy P, Leung A, Ritchie K, Evans E, (1999) Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy. Nature 397: 50-53.
24. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A, (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70: 401-410.
25. Pankov R, Endo Y, Even-Ram S, Araki M, Clark K, et al. (2005) A Rac switch regulates random versus directionally persistent cell migration. Journal of Cell Biology 170: 793-802.
26. Veigel C, Molloy JE, Schmitz S, Kendrick-Jones J, (2003) Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers. Nature Cell Biology 5: 980-986.
27. Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, et al. (2009) Coordination of Rho GTPase activities during cell protrusion. Nature 461: 99-103.
28. Arnold M, Cavalcanti-Adam EA, Glass R, Blümmel J, Eck W, et al. (2004) Activation of Integrin Function by Nanopatterned Adhesive Interfaces. ChemPhysChem 5: 383-388.
29. Munevar S, Wang Y-l, Dembo M, (2001) Traction Force Microscopy of Migrating Normal and H-ras Transformed 3T3 Fibroblasts. Biophysical Journal 80: 1744-1757.
30. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, et al. (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8: 241-254.
31. Wozniak MA, Desai R, Solski PA, Der CJ, Keely PJ, (2003) ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. Journal of Cell Biology 163: 583-595.
32. Lo C-M, Wang H-B, Dembo M, Wang Y-l, (2000) Cell Movement Is Guided by the Rigidity of the Substrate. Biophysical Journal 79: 144-152.
33. Dokukina IV, Gracheva ME, (2010) A Model of Fibroblast Motility on Substrates with Different Rigidities. Biophysical Journal 98: 2794-2803.
34. Katz B-Z, Zamir E, Bershadsky A, Kam Z, Yamada KM, et al. (2000) Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions. Molecular Biology of the Cell 11: 1047-1060.
35. Pathak A, Kumar S, (2011) Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness. Integrative Biology doi:10.1039/C0IB00095G.