Why has the antidepressant-placebo difference in antidepressant clinical trials diminished over the past three decades?

CNS Neuroscience and Therapeutics

Volumn 16, Issue 4, 2010, Pages 217-226

  Khan, Arif ^a,b   Bhat, Amritha ^a   Kolts, Russell ^c   Thase, Michael E ^d   Brown, Walter ^e  

^a Northwest Clinical Research Center 1951   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c EASTERN WASHINGTON UNIVERSITY   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e BROWN UNIVERSITY   (United States)

Author keywords

Antidepressant; Clinical trials; Placebo

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO;

CLINICAL TRIAL (TOPIC); DEPRESSION; HUMAN; PROCEDURES; PSYCHOLOGICAL RATING SCALE; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ANTIDEPRESSIVE AGENTS; CLINICAL TRIALS AS TOPIC; DEPRESSION; HUMANS; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 77954357077     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2010.00151.x     Document Type: Article

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