The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia

Journal of Orthopaedic Science

Volumn 16, Issue 1, 2011, Pages 93-98

  Hak, David J ^d   Schulz, Kurt S ^a   Khoie, Behrang ^b   Hazelwood, Scott J ^c  

^a Burlington Veterinary Specialists   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c CALIFORNIA POLYTECHNIC STATE UNIVERSITY   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PLACEBO; ROFECOXIB;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE STRENGTH; COMPRESSION OSTEOSYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; FRACTURE HEALING; MALE; NONHUMAN; PERIIMPLANT FRACTURE; POSTOPERATIVE COMPLICATION; TIBIA FRACTURE; TIBIA OSTEOTOMY; TREATMENT OUTCOME;

EID: 79953331403     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00776-010-0016-0     Document Type: Article

References (27)

1. Allen HL, Wase A, Bear WT. Indomethicin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand. 1980;51:595-600. (Pubitemid 10090468)
2. Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal anti-inflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995;9:392-400.
3. Ho ML, Chang JK, Wang GJ. Antiinflammatory drug effects on bone repair and remodeling in rabbits. Clin Orthop. 1995;313:270-8.
4. Høgevold HE, Grøgaard B, Reikera° s O. Effects of short-term treatment with corticosteroids and indomethacin on bone healing: a mechanical study of osteotomies in rats. Acta Orthop Scand. 1992;63:607-11.
5. Bergenstock M, Min W, Simon AM, Sabatino C, O'Connor JP. A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats. J Orthop Trauma. 2005;19:717-23. (Pubitemid 44378210)
6. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Webb EG, Thiede MA, Einhorn TA. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114-25. (Pubitemid 46059150)
7. Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am. 2007;89:500-11. (Pubitemid 46365350)
8. Herbendick MA, Sprott D, Stills H, Lawless M. Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Am J Orthop. 2008;37:E133-7.
9. Goodman S, Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL. Cox-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res. 2002;20:1164-9. (Pubitemid 35363972)
10. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell R, Morton D, Lanas A, Konstam MA, Baron JA. Adenomatous polyp prevention on Vioxx (APPROVe) trial investigators cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352:1092-102. (Pubitemid 40365350)
11. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL, Boyce SW, Verburg KM. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. New Engl J Med. 2005;352:1081-91. (Pubitemid 40365349)
12. Reuben SS, Fingeroth R, Krushell R, Maciolek H. Evaluation of the safety of the perioperative administration of rofecoxib for total knee arthroplasty. J Arthroplasty. 2002;17:26-31. (Pubitemid 34098199)
13. Ruoff G, Lema M. Strategies in pain management: new and potential indications for Cox-2 specific inhibitors. J Pain Symptom Manage. 2003;25(2):S21-31.
14. Sinatra R. Role of Cox-2 inhibitors in the evolution of acute pain management. J Pain Symptom Manage. 2002;24(1):S18-27.
15. Sinatra R, Torres J, Bustos AM. Pain management after major orthopaedic surgery: current strategies and new concepts. J Am Acad Orthop Surg. 2002;10:117-29.
16. Rahn BA, Gallinaro P, Baltensperger A, Perren SM. Primary bone healing: an experimental study in the rabbit. J Bone Joint Surg Am. 1971;53:783-6.
17. White A, Panjabi M, Southwick W. The four biomechanical stages of fracture repair. J Bone Joint Surg Am. 1977;59:188-92. (Pubitemid 8067252)
18. Terjesen T. Bone healing after metal plate fixation and external fixation of osteotomized rabbit tibia. Acta Orthop Scand. 1984;55:69-77. (Pubitemid 14157653)
19. Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004;86:116-23. (Pubitemid 38057344)
20. Simon AM, Manigrasso MB, O'Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res. 2002;17:963-76. (Pubitemid 34535133)
21. Karachalios T, Boursinos L, Poultsides L, Khaldi L, Malizos KN. The effect of short-term administration of low therapeutic doses of anti-cox-2 agents on the healing of fractures: an experimental study in rabbits. J Bone Joint Surg Br. 2007;89:1253-60. (Pubitemid 350057968)
22. Mullis BH, Copland ST, Weinhold PS, Miclau T, Lester GE, Bos GD. Effect of cox-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury, Int J Care Injured. 2006;37:827-37.
23. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670-5. (Pubitemid 36763489)
24. Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulated mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002;109:1405-25.
25. Hochberg MC, Melin JM, Reicin A. Cox-2 inhibitors and fracture healing: an argument against such an effect. J Bone Miner Res. 2003;18:583.
26. Burd TA, Hughes MS, Anglen JO. Heterotopic ossification prophylaxis with indomethicin increases the risk of long-bone non-union. J Bone Joint Surg Br. 2003;85:700-5. (Pubitemid 36927035)
27. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82:655-8.