Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season

Annals of Allergy, Asthma and Immunology

Volumn 106, Issue 4, 2011, Pages 336-341

  Badorrek, Philipp ^a   Dick, Melanie ^a   Hecker, Hartmut ^b   Schaumann, Frank ^a   Sousa, Ana R ^c   Murdoch, Robert ^c   Hohlfeld, Jens M ^a   Krug, Norbert ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; CETIRIZINE; PLACEBO; PSEUDOEPHEDRINE;

ADULT; ALLERGY TEST; ARTICLE; ATOPIC DERMATITIS; CHILD; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG SCREENING; DRUG WITHDRAWAL; ENVIRONMENTAL CHALLENGE CHAMBER; FEMALE; GRASS POLLEN; HAY FEVER; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; POLLEN ALLERGY; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; SCREENING TEST; TREATMENT RESPONSE;

ADULT; AREA UNDER CURVE; ATMOSPHERE EXPOSURE CHAMBERS; CETIRIZINE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; POLLEN; PROSPECTIVE STUDIES; PSEUDOEPHEDRINE; RESPIRATORY FUNCTION TESTS; RHINITIS, ALLERGIC, SEASONAL; SEASONS; YOUNG ADULT;

EID: 79953322601     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/j.anai.2010.12.018     Document Type: Article

References (15)

1. Schoenwetter WF. Allergic rhinitis: epidemiology and natural history. Allergy Asthma Proc. 2000;21:1-6.
2. Berkowitz RB, Woodworth GG, Lutz C, et al. Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit. Ann Allergy Asthma Immunol. 2002;89:38-45. (Pubitemid 36188066)
3. Day JH, Briscoe M, Widlitz MD. Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmental exposure unit. J Allergy Clin Immunol. 1998;101:638-645. (Pubitemid 28228308)
4. Horak F, Zieglmayer PU, Zieglmayer R, Kavina A, Lemell P. Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration. Br J Clin Pharmacol. 2005;60:24-31. (Pubitemid 40942777)
5. Krug N, Hohlfeld JM, Geldmacher H, et al. Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit. Allergy. 2005;60:354-359. (Pubitemid 40293353)
6. Patel P, D'Andrea C, Sacks HJ. Onset of action of azelastine nasal spray compared with mometasone nasal spray and placebo in subjects with seasonal allergic rhinitis evaluated in an environmental exposure chamber. Am J Rhinol. 2007;21:499-503. (Pubitemid 47360041)
7. Hashiguchi K, Tang H, Fujita T, Suematsu K, Gotoh M, Okubo K. Bepotastine besilate OD tablets suppress nasal symptoms caused by Japanese cedar pollen exposure in an artificial exposure chamber (OHIO Chamber). Expert Opin Pharmacother. 2009;10:523-529.
8. Akerlund A, Andersson M, Leflein J, Lildholdt T, Mygind N. Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication. J Allergy Clin Immunol. 2005;115(3 Suppl 1):S460-S482. (Pubitemid 40320996)
9. Badorrek P, Dick M, Schauerte A, et al. A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis. Int J Clin Pharmacol Ther. 2009;47:71-77.
10. Grosclaude M, Mees K, Pinelli ME, Lucas M, Van d, V. Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. Rhinology. 1997;35:67-73.
11. Horak F, Toth J, Marks B, et al. Efficacy and safety relative to placebo of an oral formulation of cetirizine and sustained-release pseudoephedrine in the management of nasal congestion. Allergy. 1998;53:849-856. (Pubitemid 28442791)
12. Krug N, Hohlfeld JM, Larbig M, et al. Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis. Clin Exp Allergy. 2003;33:1667-1674. (Pubitemid 38005386)
13. Potter PC, Berman D, Toerien A, Malherbe D, Weinberg EG. Clinical significance of aero-allergen identification in the western Cape. S Afr Med J. 1991;79:80-84.
14. Patel D, Garadi R, Brubaker M, et al. Onset and duration of action of nasal sprays in seasonal allergic rhinitis patients: olopatadine hydrochloride versus mometasone furoate monohydrate. Allergy Asthma Proc. 2007;28:592-599.
15. Patel P, Patel D, Kunjibettu S, Hall N, Wingertzahn MA. Onset of action of ciclesonide once daily in the treatment of seasonal allergic rhinitis. Ear Nose Throat J. 2008;87:340-353.